AutismKB 2.0

Annotation Detail for BIRC6


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Basic Information Top
Gene Symbol:BIRC6 ( APOLLON,BRUCE,FLJ13726,FLJ13786,KIAA1289 )
Gene Full Name: baculoviral IAP repeat-containing 6
Band: 2p22.3
Quick LinksEntrez ID:57448; OMIM: 605638; Uniprot ID:BIRC6_HUMAN; ENSEMBL ID: ENSG00000115760; HGNC ID: 13516
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in increased expression of BIRC6 mRNAincreases expression 18544908
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BIRC6 mRNAdecreases expression 19150397
D004317 Doxorubicin Doxorubicin results in increased expression of BIRC6 mRNAincreases expression 17521628
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of BIRC6 mRNAincreases expression 17942748
D005472 Fluorouracil BIRC6 protein affects the susceptibility to Fluorouracilaffects response to substance 18239605
D005665 Furosemide Furosemide affects the expression of BIRC6 mRNAaffects expression 17497460
D009151 Mustard Gas Mustard Gas results in increased expression of BIRC6 mRNAincreases expression 18988085
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BIRC6 mRNAdecreases expression 18691609
D014415 Tunicamycin Tunicamycin results in decreased expression of BIRC6 mRNAdecreases expression 17127020
C088658 zoledronic acid zoledronic acid results in decreased expression of BIRC6 mRNAdecreases expression 19036117
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D058186 Acute Kidney Injury zoledronic acid 4.6319715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.7220200999
MESH:D000230 Adenocarcinoma Doxorubicin 7.3517418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3514692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.3517638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000419 Albuminuria Doxorubicin 4.7421441931
MESH:D000740 Anemia Fluorouracil 9.2317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9614601052
MESH:D001859 Bone Neoplasms zoledronic acid 5.1417312309 11697798 15867366 16121404 16778634 19442620
MESH:D001862 Bone Resorption zoledronic acid 4.8718404659 16769263 18496637 15845617 8053405 11869084
MESH:D001932 Brain Neoplasms Doxorubicin 3.9717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0418628466 16826403 16096432 16115903 18234424 15993339 19526202 16322301 18695136 15668708 15136595 15994142 15939500 11325840 18382427 15634643 16935488 15567936 16264153 17983394 15692762 16595493 17369602 17426702
MESH:D001943 Breast Neoplasms Fluorouracil 2.0419217205 18608205 15136595 16557594 18357371 16595493 16110121
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D001943 Breast Neoplasms zoledronic acid 2.0418695136 16096432
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D002276 Carcinoid Tumor Doxorubicin 13.2616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 13.2616051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.753084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.7516234567 17876044 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7517971768 18930000 17045692 16332177 16799960 17088986
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5919233551
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.361485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 11.3618695887
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 11.3618507039
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.006189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0018986760 16280240 16757204 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.6416364871 17329180 16455267 17308081 17131338 16731534 16612575 15476868 17519947 16651473 17351982 17924179 17382496 16278810 16269455 17974986 17007740 16242529 16952015 17928571 15811867 16109756 18627295 15505089 15792986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9916243910 17334414
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8420889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017110522 16105132 11677210 16919318 17681005 17333356 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 15668235 16354765 8697196 15340226
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2616340194 15001691 17169374 16510598 17172411 17725105 17018589 17287894 18772588 17016597
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6818259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6814970324 20501625 17401013 18383874 16331619 16524972 15148649 17454858 18448328 16282729 16391804 18509181 15289873 18802399 17094418 17695437 17594712 16303861 17255274 18949393 18288408 17016601
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4414986274 11461765 2444490 10774834 16109766 11529661 19923254 16781746 19420014 14550746 12594235 12153990 16081117 18071297 15619225 10663392 11834606 11743745 12392966 11739529 16393943 19416960 12958197 14725611 16177239 17562736 19370779 12540782 19164858 16485898 16227642 18713872 10915739 19085960 15968718 17522070 11421492 17906064 12705907 19739265 11287661
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.4417416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Doxorubicin 8.5318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.5311462148
MESH:D004417 Dyspnea Furosemide 5.2116935035
MESH:D004487 Edema Furosemide 12.6511834646
MESH:D004487 Edema Mustard Gas 12.6511402378 9260866 11428647 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5617359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4218037988
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6420426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6416481741 17638652 16785472 15173087 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9815345470
MESH:D005264 Femoral Fractures zoledronic acid 6.0616234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8319069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Doxorubicin 3.4517150277
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.2915692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.2915102660 18337622 15162350
MESH:D034381 Hearing Loss Furosemide 4.9817868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.6016244372 16495754 16879835 17888722 17875725 16144979 14766674 18006777 16330681 16244371 18674790 12587719 16707910
MESH:D006333 Heart Failure Doxorubicin 7.9417481944
MESH:D006333 Heart Failure Furosemide 7.9416845234 12660669 16011733
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0715692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.5618501091 17606976 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 8.4716870215
MESH:D006930 Hyperalgesia zoledronic acid 8.4716769263
MESH:D006934 Hypercalcemia Furosemide 11.8817652376
MESH:D006934 Hypercalcemia zoledronic acid 11.8818089816 19622757
MESH:D053565 Hypercalciuria Furosemide 5.8917652376
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.1415086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.5016612254
MESH:D006996 Hypocalcemia zoledronic acid 6.4612669777
MESH:C537153 Hypomagnesemia primary Furosemide 5.8911041285
MESH:D007019 Hypoproteinemia Furosemide 6.1416096441
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007022 Hypotension Furosemide 4.8011041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.6815811171
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Mustard Gas 5.329260866 9357497 11428620 17524151 11428631 8975870 16001271 11428647 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 10.7812587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 10.7815369732 16775033 15699352
MESH:D007674 Kidney Diseases Furosemide 10.7811041285
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3316707910
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4516985049
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4216085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.9418089816
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.4816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 12969438 16610002 16611625 12587719 19784758 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 4.6818383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6816984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.2517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2512151625
MESH:D008171 Lung Diseases Mustard Gas 3.5618161513 18702808
MESH:D008175 Lung Neoplasms Doxorubicin 5.026189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 5.0215246190
MESH:D008175 Lung Neoplasms Mustard Gas 5.028781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008223 Lymphoma Doxorubicin 3.5816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.9015458769
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 6.9017312309
MESH:D008545 Melanoma Doxorubicin 2.3116827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Doxorubicin 6.8417638057
MESH:D008654 Mesothelioma zoledronic acid 6.8416675582
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6715792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7616757204 18986760
MESH:D052016 Mucositis Doxorubicin 5.0317415656
MESH:D009101 Multiple Myeloma zoledronic acid 4.2016996129 19621390 18089719
MESH:D009203 Myocardial Infarction Doxorubicin 3.0115857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.4818259882
MESH:D009362 Neoplasm Metastasis zoledronic acid 6.4815867366 19139120 17312309
MESH:D009369 Neoplasms marker/mechanism 18239605
MESH:D009369 Neoplasms Fluorouracil 2.6818600527 18239605 16928823
MESH:D009397 Nephrocalcinosis Furosemide 6.1415086907
MESH:D009401 Nephrosis Doxorubicin 4.9816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1515640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009447 Neuroblastoma Doxorubicin 3.3415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009503 Neutropenia Mustard Gas 4.1516761898 7688884
MESH:D053206 Nocturnal Enuresis Furosemide 6.1417945291
MESH:D010014 Osteolysis zoledronic acid 5.6115867366
MESH:D010024 Osteoporosis zoledronic acid 4.1317882678
MESH:D012516 Osteosarcoma Doxorubicin 4.2515930896
MESH:D010146 Pain Acetaminophen 7.4516870215
MESH:D010146 Pain zoledronic acid 7.4516475674
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4217638057
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D011141 Polyuria Furosemide 5.8917945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7416888761 15897917 16729912 15749863 18437689 16868541
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7419082440 18626508
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.7412438248 19103299
MESH:D011537 Pruritus Ethinyl Estradiol 10.3316919318 15861022
MESH:D011537 Pruritus Mustard Gas 10.3318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9810334151 17894541 17620002 17266442 17720292
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1615538739 18722050 18286688 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 4.4417922066
MESH:D015427 Reperfusion Injury Furosemide 3.9816526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.8015912074 12394941 16096441
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012509 Sarcoma Doxorubicin 4.1517203757 17710206 15675481 15625365 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 11.3116326096 14601052
MESH:D012512 Sarcoma, Ewing's zoledronic acid 11.3116121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0317846226
MESH:D012871 Skin Diseases Mustard Gas 2.7512880345 16961503 15451306
MESH:D012878 Skin Neoplasms Doxorubicin 5.9315692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7816767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.9318396642 16424979 18567086 16951190 17522103 15786421 17172411 19084572 19015929 17498489
MESH:D013274 Stomach Neoplasms Furosemide 2.9317052386
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5016010429 17909728
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8217653716
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4417638931 16364871 17678736 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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