AutismKB 2.0

Annotation Detail for ODZ2


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Basic Information Top
Gene Symbol:ODZ2 ( DKFZp686A1568,TEN-M2,TNM2 )
Gene Full Name: odz, odd Oz/ten-m homolog 2 (Drosophila)
Band: 5q34
Quick LinksEntrez ID:57451; OMIM: 610119; Uniprot ID:; ENSEMBL ID: ENSG00000145934; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ODZ2 mRNAdecreases expression 20406850
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ODZ2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ODZ2 mRNAincreases expression 20458559
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ODZ2 mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ODZ2 mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of ODZ2 mRNAincreases expression 18007998
D016572 Cyclosporine Cyclosporine results in increased expression of ODZ2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ODZ2 mRNAaffects cotreatment|decreases expression 18164116
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ODZ2 mRNAaffects binding|decreases expression|increases activity 19710929
D014635 Valproic Acid Valproic Acid results in increased expression of ODZ2 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of ODZ2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 11.666695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.6619389873
MESH:D000236 Adenoma Diethylnitrosamine 11.666695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7517162532 19061943 16434500 19052882 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7516434500
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.2317497229
MESH:D001008 Anxiety Disorders vinclozolin 9.2319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9918177632 20603192 19232924 18316065 18396377 18985861 19460635 17507914 18940202 18558336 18775368 15238991 17688650 17157402 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9017474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 1.9017123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9017474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7115073043 16217749 15553829 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7120101231 16540662 16878318 17978847 18494052 18665156 18210153 18691550 18978308 17428255 18788625 16681979 16328049 16830150 19052882 20935162 3084413 18056438 19919837 19171122 20512989 17173139 20214788 11831363 19383236 19418558 20727157 16779866 16935385 20524982 17162532 16698587 16569478 19519916 17761372 20007298 19107877 19539802 10672840 21159647 17055752 20432363 18506893 17138121 19701751 20084675 18393292 19335982 16502159 19394651 20514400 3581430 19208518 18971187 16288022 18785209 16807293 10737359 19822196
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.716135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.7117174075 7505956 21159647 2727394
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7410525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7416575769 17688650 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4819107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.481733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.717562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005234 Fatty Liver arsenic trioxide 26.2415073043
MESH:D005234 Fatty Liver Cyclosporine 26.2419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 26.2421071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 26.2419236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 26.2414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1718467677 19176532 16221962 19772884
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007248 Infertility, Male vinclozolin 3.1316467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007333 Insulin Resistance bisphenol A 7.6116393666
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9816968895 19850784 16467208 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9817596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3012712474 11161223 19075265 17869043 19642359 19225113 16112521 16330433 19035177 15748426 11468182 12018890 16891316 16966277 15213294 17649720 17712046 15336539 17217047 16331271 9834237 15622746 17107899 12679006 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918665156 20032147 18522880 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.637678174
MESH:D008113 Liver Neoplasms arsenic trioxide 18.6314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.6321137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.6319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.6318754104 19073162 19426721 9163691 19638242 19690152 20452335 20501860 18977376 19833225 15885732 19996281 15175105 19255062 20434301 19551842 18648771 19256749 19254457 20118626 19850985 20583210 18644402 2422723 20101389 12771043 19812893 2862719 19499222 19427195 21167192 20405173 19294768 20137499 21278145 18978307 20492335 10737359 19642983 21071580 12112319 21047994 19090486 16942905
MESH:D008113 Liver Neoplasms pirinixic acid 18.6320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.872876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.8720377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.8718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.8719004024 18079962 2563599 18308698 18282651 17854601 18093689 19539802 18164116 21159647 9362446 16842330 17174075 18544905 17942915 18775883 18253720 19009564 19126423 16267830 3124819 19519916
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5119825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5118569708 20464547 20869020 18520028 6695378 18816296 17053015 20064080 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5120970405 20512841 6695378 21163286
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2918765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2019549372 11468182 15949261 14977855 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6716882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.6717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.1311399458 16427766
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6210525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.6216359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4419769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4216540662
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D011230 Precancerous Conditions Cyclosporine 9.3612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.362563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.5210548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.5220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.5218220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5416740699
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012640 Seizures Valproic Acid 6.2514763951 16876388 1511512 17978042 11044598 11738929 3137016 15475178
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.402093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4018456281
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816684133 16045194
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.557505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.5811780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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