AutismKB 2.0

Annotation Detail for REXO1


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Basic Information Top
Gene Symbol:REXO1 ( ELOABP1,EloA-BP1,KIAA1138,REX1,TCEB3BP1 )
Gene Full Name: REX1, RNA exonuclease 1 homolog (S. cerevisiae)
Band: 19p13.3
Quick LinksEntrez ID:57455; OMIM: 609614; Uniprot ID:REXO1_HUMAN; ENSEMBL ID: ENSG00000079313; HGNC ID: 24616
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of REXO1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of REXO1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of REXO1 mRNAdecreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of REXO1 mRNAdecreases expression 18648102
D014212 Tretinoin Tretinoin results in decreased expression of REXO1 mRNAdecreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.941917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.456135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.457505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.419022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8317551590 9224671 16925845 9125849 10589399 9211117 8800419 9664655 14991402 9142499
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.5618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.5618551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2811298694 12868966 8970840 18759878 11906362 8156756 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.7218289764 9653073 9022650 6679447 18692083 16192314 8291058 9328219 11289319 1440618 6482804 7440962 18648102
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0514991402 9664655
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.2316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.2316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.236582329
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3716823087 17368321 17339181 9834237 17294898 16331271 19642359 15748426 17301526 16766008 16788101 17506722 16891316 12679006 17107899 19225113 19035177 17217047 17649720 17712046 16935935 19029980 19075265 16140955 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.257678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.582876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.586587162 598648 3712494 1399818
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.217678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms Tretinoin 2.5516594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.956679447
MESH:D009436 Neural Tube Defects Tretinoin 7.959142499
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.1712819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 17.1716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 17.176482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6518551238
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.051399818 7505956 3712494 6582329 6587162
MESH:D013964 Thyroid Neoplasms Tretinoin 8.0516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.968074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.8610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.8610091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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