AutismKB 2.0

Annotation Detail for PTH2R


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Basic Information Top
Gene Symbol:PTH2R ( PTHR2 )
Gene Full Name: parathyroid hormone 2 receptor
Band: 2q34
Quick LinksEntrez ID:5746; OMIM: 601469; Uniprot ID:PTH2R_HUMAN; ENSEMBL ID: ENSG00000144407; HGNC ID: 9609
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTH2R mRNAaffects expression 16483693
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PTH2R mRNAincreases expression 20360939
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PTH2R mRNAaffects cotreatment|decreases expression 17404688
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PTH2R mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PTH2R mRNAaffects cotreatment|decreases expression 17404688
D014415 Tunicamycin Tunicamycin results in increased expression of PTH2R mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000236 Adenoma Diethylnitrosamine 3.016695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.6816434500 19061943 18056438 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.6816434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 4.6815665606 15380490 15845082
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9117474063
MESH:D001943 Breast Neoplasms Estradiol 1.9112948864 17018787 19861407 14630087 17289903 16675129 17261762 18497071
MESH:D001943 Breast Neoplasms Progesterone 1.9117614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1120727157 17428255 18393292 20007298 18971187 20524982 19418558 18506893 16328049 17978847 18494052 16698587 16502159 16540662 18691550 19394651 17055752 16779866 20101231 19171122 19383236 21159647 19539802 18978308 20514400 16807293 19919837 19519916 19208518 19822196 17162532 16288022 3084413 17138121 16878318 11831363 17761372 20935162 18056438 17173139 16681979 20084675 18788625 18785209 20432363 16830150 19701751 3581430 18210153 19335982 16935385 20214788 19052882 10737359 19107877 20512989 10672840 18665156 16569478
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1116924424
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.407505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4018566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1219107877
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1617692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.1711473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 4.0716134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.7820387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.7820131406 19236843
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 19772884 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007249 Inflammation Diethylnitrosamine 5.6518785209
MESH:D007249 Inflammation Progesterone 5.6515869954
MESH:D007333 Insulin Resistance Estradiol 7.8416627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.8416306350
MESH:D007674 Kidney Diseases Estradiol 2.7415618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2415610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9818522880 19638242 20032147 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7715885732 19996281 18648771 19499222 19551842 2862719 20101389 21071580 19690152 19833225 19254457 12112319 18978307 20137499 20434301 20583210 15175105 21278145 19426721 19427195 19812893 19642983 18644402 9163691 20501860 16942905 19850985 10737359 2422723 21047994 19294768 21167192 18754104 20492335 18977376 19255062 20118626 19256749 20452335 19073162 19090486 20405173 19638242 12771043
MESH:D008113 Liver Neoplasms pirinixic acid 4.7716377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.8118079962 18282651 17174075 19126423 19004024 18253720 16267830 18164116 17854601 18093689 18544905 19519916 19009564 9362446 19539802 18308698 21159647 16842330 2563599 3124819 17942915 18775883
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6916891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.6911408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.0616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0616411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations Estradiol 4.0311399458 16427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.1417393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D013119 Spinal Cord Injuries Progesterone 4.7416503802 15862959
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162400333
    • No data
    No data
    Releated drug ID Related drug Name
    PA451620teriparatide
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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