AutismKB 2.0

Annotation Detail for PLEKHG1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PLEKHG1 ( ARHGEF41,FLJ31738,KIAA1209 )
Gene Full Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Band: 6q25.1
Quick LinksEntrez ID:57480; OMIM: NA; Uniprot ID:PKHG1_HUMAN; ENSEMBL ID: ENSG00000120278; HGNC ID: 20884
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
panic disorder
Desease Name
Panic disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PLEKHG1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PLEKHG1 mRNAdecreases expression 20458559
D016572 Cyclosporine Cyclosporine results in increased expression of PLEKHG1 mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of PLEKHG1 mRNAincreases expression 16169686
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.6216206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.6216197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.823084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8215073043 14691202 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.821917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Acetaminophen 7.9210977129
MESH:D002386 Cataract Tretinoin 7.9217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7912371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7710525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7714991402 8800419 9224671 10589399 9664655 17551590 9211117 9125849 16925845 9142499
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6719164858 12392966 19923254 18713872 19420014 19370779 17906064 11743745 19085960 11529661 15968718 19739265 11834606 16393943 11421492 17562736 16177239 14725611 12958197 16781746 17522070 10774834 2444490 16485898 14986274 10663392 16227642 12540782 18071297 11461765 10915739 19416960 12705907 14550746 11287661 11739529 16109766 12153990 12594235 15619225 16081117
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005124 Eye Abnormalities Tretinoin 3.879664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 9.2015073043
MESH:D005234 Fatty Liver Cyclosporine 9.2019224547
MESH:D005355 Fibrosis Cyclosporine 10.6212639820 12168785
MESH:D005355 Fibrosis Tretinoin 10.6217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D005909 Glioblastoma Tretinoin 3.2417312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.079664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006930 Hyperalgesia Acetaminophen 8.7216870215
MESH:D006930 Hyperalgesia Tretinoin 8.7216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0812371664
MESH:D007938 Leukemia arsenic trioxide 6.9115070760
MESH:D007938 Leukemia Tretinoin 6.9117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.9319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.9316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0716467208 17050201 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.4516331271 17649720 16966277 12018890 15622746 19035177 15336539 16823087 19225113 17217047 11161223 12712474 16891316 16112521 12679006 11468182 19075265 19642359 16330433 9834237 15748426 17107899 15213294 17712046 17869043
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.4517712046 16935935 17368321 17506722 19642359 16140955 17649720 19075265 19035177 17361223 16331271 12679006 16788101 19225113 16766008 17217047 17107899 17301526 9834237 19029980 15748426 16891316 17339181 17294898 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.7012969438 19460945 19784758 11587558 19014921 16610002 12587719 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3814977855 11468182 15949261 19549372 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.0616105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0617596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009369 Neoplasms Tretinoin 2.5716946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects arsenic trioxide 8.1110525206
MESH:D009436 Neural Tube Defects Tretinoin 8.119142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2016624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2016936753
MESH:D010146 Pain Acetaminophen 7.7516870215
MESH:D010146 Pain Tretinoin 7.7516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6715580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6715976015
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5616116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D012878 Skin Neoplasms Tretinoin 2.7616467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5317007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.5317261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.2419014326
MESH:D013964 Thyroid Neoplasms Tretinoin 8.2416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6011780464 20435036 12845720 12973940
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134922441
    • No data
    Releated disease ID Related disease Name
    PA447212Panic Disorder
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved