AutismKB 2.0

Annotation Detail for HEG1


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Basic Information Top
Gene Symbol:HEG1 ( HEG,KIAA1237,MGC72175,MST112,MSTP112 )
Gene Full Name: HEG homolog 1 (zebrafish)
Band: 3q21.2
Quick LinksEntrez ID:57493; OMIM: NA; Uniprot ID:HEG1_HUMAN; ENSEMBL ID: ENSG00000173706; HGNC ID: 29227
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of HEG1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HEG1 proteinaffects expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of HEG1 mRNAdecreases expression 15336504
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HEG1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HEG1 mRNAincreases expression 19619570
D020849 Raloxifene Raloxifene affects the expression of HEG1 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of HEG1 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of HEG1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of HEG1 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of HEG1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HEG1 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HEG1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HEG1 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HEG1 mRNAincreases expression 20159946
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000419 Albuminuria Raloxifene 4.9217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Estradiol 1.9812948864 16675129 17289903 18497071 14630087 19861407 17261762 17018787
MESH:D001943 Breast Neoplasms Raloxifene 1.9815572757 17595753 17893378 17952589 15758505 17049068 16837676 17440819 16912660 17242785 17261762 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 1.9817242785 19155303 20005174 18351453 19289846 19221464 18425577 19115204 19142967 20135344 18984771 11161223 17049068 18815881 19244106 16202921 19487384 19011961 16818667 15565566 21152245 20859285 19288272 18855134 17440819 15668708 20390343 20544844 18821012 19189210 18997820 18629630 20065188 19084267 19103187 17893378 16273361 19189212 17261762 19059307 19410462 21138602 19200415 19066611 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.853084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8516924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8516924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.4017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 15340226 12621046 8697196 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 16.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.5217308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.5219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7819370779 19739265 14550746 17906064 18713872 19085960 11529661 19416960 11743745 17522070 12540782 11834606 11739529 16227642 17562736 18071297 12594235 11287661 16393943 10915739 19164858 12958197 10663392 16081117 2444490 16781746 19923254 14725611 16485898 11421492 19420014 11461765 10774834 14986274 12392966 16109766 15619225 16177239 15968718 12705907 12153990
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Raloxifene 7.8015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.8012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.3619031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.9618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9619155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Raloxifene 8.9417473493
MESH:D005234 Fatty Liver Tamoxifen 8.9419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Raloxifene 5.5217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5218850075 18670907
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1818625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 12587719 19784758 16610002 12969438 16611625 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.932125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.9316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.348603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5214755239
MESH:D008175 Lung Neoplasms Tamoxifen 3.5218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5211884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5316891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5319196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.5811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010024 Osteoporosis Raloxifene 3.5515775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 15758505 15579764 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5415731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.978532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9716192470
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 15.2419048282
MESH:D013978 Tibial Fractures Raloxifene 15.2419048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5416712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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