AutismKB 2.0

Annotation Detail for NLGN4X


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Basic Information Top
Gene Symbol:NLGN4X ( ASPGX2,AUTSX2,HLNX,HNLX,KIAA1260,MGC22376,NLGN,NLGN4 )
Gene Full Name: neuroligin 4, X-linked
Band: Xp22.32-p22.31
Quick LinksEntrez ID:57502; OMIM: 300427; Uniprot ID:NLGNX_HUMAN; ENSEMBL ID: ENSG00000146938; HGNC ID: 14287
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1916Pervasive development disorder
2124Autistic disorder
Desease Name
Biochemical measures
PSYCH
Autism
No data
Desease Name
Asperger syndrome, susceptibility to, X-linked-2
Autism, susceptibility to, X-linked-2
Mental retardation, X-linked
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D011374 Progesterone Progesterone results in increased expression of NLGN4X mRNAincreases expression 17404688
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
OMIM:300497 ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 2 marker/mechanism
OMIM:300495 AUTISM, SUSCEPTIBILITY TO, X-LINKED 2 marker/mechanism
MESH:D001321 Autistic Disorder marker/mechanism 12669065
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.7517868700
MESH:D001930 Brain Injuries Progesterone 5.1715845082 15380490 15665606
MESH:D001943 Breast Neoplasms Progesterone 2.4016175315 15562024 17614352
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 18252227
MESH:D003929 Diabetic Neuropathies Progesterone 5.4017187935
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.5617692515
MESH:D004715 Endometriosis Progesterone 4.3416134523
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 5.3115869954
MESH:D007249 Inflammation Progesterone 2.8315869954
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.1811408345 17203775
MESH:D010051 Ovarian Neoplasms Progesterone 2.6417393432 16525653
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9918045962
MESH:D013119 Spinal Cord Injuries Progesterone 5.3716503802 15862959
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31650
    • No data
    Releated disease ID Related disease Name
    PA447198Autistic Disorder
    PA447216Schizophrenia
    PA153906318Autism Spectrum Disorder
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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