AutismKB 2.0

Annotation Detail for SRGAP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SRGAP1 ( ARHGAP13,FLJ22166,KIAA1304 )
Gene Full Name: SLIT-ROBO Rho GTPase activating protein 1
Band: 12q14.2
Quick LinksEntrez ID:57522; OMIM: 606523; Uniprot ID:SRGP1_HUMAN; ENSEMBL ID: ENSG00000196935; HGNC ID: 17382
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
Signaling by Rho GTPases
Pathway IDPathway Name
200050Regulation of RhoA activity
Pathway IDPathway Name
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SRGAP1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SRGAP1 mRNAdecreases expression 20382639
20018196
D002117 Calcitriol Calcitriol results in increased expression of SRGAP1 mRNAincreases expression 16002434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1920146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 2.1911237771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0211237771
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0120889678
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.5215138306
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6416530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1720195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718520028 20064080 17053015 6695378 20464547 18569708 18816296 20869020 20135361
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.5215572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.1916289102 12479363 18247401 16644109 15754350
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3117053015
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134887956
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    Releated drug ID Related drug Name
    PA448068salbutamol
    PA134687887selective beta-2-adrenoreceptor agonists
    PA164713253Selective beta-2-adrenoreceptor agonists
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved