AutismKB 2.0

Annotation Detail for CGN


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Basic Information Top
Gene Symbol:CGN ( DKFZp779N1112,FLJ39281,KIAA1319 )
Gene Full Name: cingulin
Band: 1q21.3
Quick LinksEntrez ID:57530; OMIM: 609473; Uniprot ID:CING_HUMAN; ENSEMBL ID: ENSG00000143375; HGNC ID: 17429
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CGN mRNAdecreases expression 19933214
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CGN proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of CGN mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of CGN mRNAdecreases expression 20106945
D010634 Phenobarbital Phenobarbital results in decreased expression of CGN mRNAdecreases expression 19270015
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CGN mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.886195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.8815322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.6717620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Estradiol 1.9119861407 17018787 17261762 14630087 17289903 16675129 12948864 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8312619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8317173139 1701930 20007298 6705139 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 16354765 8697196 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1711473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Cyclosporine 9.9112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.9120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Phenobarbital 9.8716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.8715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 16959395 8697196 18606429 16354765
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1616393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.498314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.4915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1812371664
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.0118177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 8.0119482888 8742319 15975961 19812893 21047994 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.908603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.9018308698 6150874 17172636 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.9012151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3714755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3711884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7411807958 11408345 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.7711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7714600291
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.9412371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.942563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures Phenobarbital 2.894039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04530 Tight junction
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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