AutismKB 2.0

Annotation Detail for HACE1


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Basic Information Top
Gene Symbol:HACE1 ( - )
Gene Full Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Band: 6q16.3
Quick LinksEntrez ID:57531; OMIM: 610876; Uniprot ID:HACE1_HUMAN; ENSEMBL ID: ENSG00000085382; HGNC ID: 21033
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2000Multiple malignancy
2053Colon cancer
Desease Name
height
menarche (age at onset)
thyroid stimulating hormone
METABOLIC
DEVELOPMENTAL
REPRODUCTION
Desease Name
Thyroid stimulating hormone
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HACE1 mRNAaffects expression 21346803
D007213 Indomethacin Indomethacin results in decreased expression of HACE1 mRNAdecreases expression 16984733
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Indomethacin 2.8716537180
MESH:D000236 Adenoma Indomethacin 3.7011497255
MESH:D016301 Alveolar Bone Loss Indomethacin 6.4417225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7817627676 15579461
MESH:D001014 Aortic Aneurysm Indomethacin 5.5210231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.6410388637
MESH:D018771 Arthralgia Indomethacin 6.242160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.9011248219
MESH:D001477 Bartter Syndrome Indomethacin 5.7510684365
MESH:D001929 Brain Edema Indomethacin 6.0911481608
MESH:D002545 Brain Ischemia Indomethacin 5.3012524144
MESH:D001943 Breast Neoplasms Indomethacin 2.7817401462
MESH:D002056 Burns Indomethacin 5.4710459503
MESH:D002100 Cachexia Indomethacin 5.8911239499 15625704 15141370 16537180
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.3816705839
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 3.3816391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.6111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 6.2418791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.5617341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9515482327 12636206
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.096135515
MESH:D002764 Cholecystitis Indomethacin 6.2411181007
MESH:D003110 Colonic Neoplasms Indomethacin 2.6515963497 11260862 15637740 15936596 15625704 15786552
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 11197048 18059344 17054584
MESH:D018352 Coronavirus Infections Indomethacin 6.7917302372
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.7818551238
MESH:D003967 Diarrhea Indomethacin 4.467907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0718551238 21346803
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 6.0418446180 16133044 18043480 12774134 16326151 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 4.8117151854 11595415 17045617 11991626 17329845 16699067 11535926 17202747 11595431 17351913 10671773
MESH:D004487 Edema Indomethacin 4.047907874 8985016 19703484 16100529 8273558 10653021 7990266
MESH:D004715 Endometriosis Indomethacin 4.6515652904
MESH:D019446 Endotoxemia Indomethacin 5.3918509659
MESH:D004751 Enteritis Indomethacin 5.8110567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.7517980183
MESH:D004802 Eosinophilia Indomethacin 4.8111298111
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8911005569
MESH:D005334 Fever Indomethacin 4.6211852909 10431976 17627676
MESH:D005354 Fibrosarcoma Indomethacin 5.7810962813
MESH:D005355 Fibrosis Indomethacin 4.8317994277
MESH:D005499 Folliculitis Indomethacin 6.2411298111
MESH:D005756 Gastritis Indomethacin 5.8115046732
MESH:D005909 Glioblastoma Indomethacin 3.8612870263
MESH:D005910 Glioma Indomethacin 3.3716487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.6911849393
MESH:D006073 Gout Indomethacin 6.2411248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 4.0515482327
MESH:D006501 Hepatic Encephalopathy Indomethacin 5.1215633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 5.3615135802
MESH:D006930 Hyperalgesia Indomethacin 4.1812727271
MESH:D034321 Hyperamylasemia Indomethacin 6.7917883296
MESH:D006940 Hyperemia Indomethacin 5.8912524144
MESH:D006949 Hyperlipidemias Indomethacin 4.7717546600
MESH:D007077 Ileal Diseases Indomethacin 6.0918306037 10574470
MESH:D007079 Ileitis Indomethacin 6.2410651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 6.4416133044
MESH:D007249 Inflammation Indomethacin 3.197812673 12568917 3291741
MESH:D007410 Intestinal Diseases Indomethacin 5.0917994277 15831440 15610444 11713966 11855677 17329856 18236018 11686837 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 6.4415241188
MESH:D007579 Jejunal Diseases Indomethacin 6.0910574470 16133968 18306037
MESH:D007674 Kidney Diseases Indomethacin 3.5117190690
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.4116705839
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.3410320625 12228301 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.2910785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6918360721
MESH:D007964 Leukocytosis Indomethacin 6.4416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.7917980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.7911479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.3718194892
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.297678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.822876784 2876786 6135515
MESH:D008175 Lung Neoplasms Indomethacin 2.3711053908 11497255 16537180
MESH:D008881 Migraine Disorders Indomethacin 4.0111903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.3712636206
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.7518551238 7678174
MESH:D009362 Neoplasm Metastasis Indomethacin 3.3211239499 16537180 11053908
MESH:D009374 Neoplasms, Experimental Indomethacin 4.9015625704 10663608
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.3812349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 6.246374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.9416049721
MESH:D010003 Osteoarthritis Indomethacin 3.937009135
MESH:D010146 Pain Indomethacin 3.893291741 13679232 17440234 17627676
MESH:D010149 Pain, Postoperative Indomethacin 5.7518702446 12538197
MESH:D010195 Pancreatitis Indomethacin 4.5217883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.7916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.6212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.7911903285
MESH:D010437 Peptic Ulcer Indomethacin 6.0411148446
MESH:D010518 Periodontitis Indomethacin 5.9817225004
MESH:D047928 Premature Birth Indomethacin 5.8917000239
MESH:D011507 Proteinuria Indomethacin 4.7711849393
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8518551238
MESH:D013272 Stomach Diseases Indomethacin 5.3018545984 17207306 10192188 17160473 16113693 10215738 18209964 15472012 17638125 15038085 16184426 10486359 16280098
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 4.1311523592 11729361 18237397 11595415 15138204 18181030 16397915 18299717 15104355 16252198 12077510 18087811 1323529 16169175 10423059 17657623 17918041 12787963 16755016 14567935 10750652 18209962 16150113 18726076 11906479 12467913 17977527 17654042 18431645 15255614 17895592 11595431 17135157 12500499 10878458 16934674 18543354 12498302 16631530 18193104 17627676 11145282
MESH:D013964 Thyroid Neoplasms Indomethacin 3.9618791128 14736730 11352223
MESH:D014456 Ulcer Indomethacin 5.7817380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.2010091137
MESH:D014839 Vomiting Indomethacin 5.8111897121
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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