Annotation Detail for ALPK3
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D004958 |
Estradiol |
Estradiol results in increased expression of ALPK3 mRNA | increases expression | 15223131
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALPK3 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.72 | 18653653 |
| MESH:D000230 |
Adenocarcinoma |
|
Estradiol |
2.18 | 11473722 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.37 | 16434500 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.70 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Estradiol |
2.10 | 12948864 16675129 18497071 17261762 17018787 19861407 17289903 14630087 |
| MESH:D002181 |
Candidiasis, Vulvovaginal |
|
Estradiol |
5.35 | 16111702 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Estradiol |
1.80 | 16924424 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Estradiol |
3.09 | 18566989 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.19 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.61 | 18249437 |
| MESH:D003928 |
Diabetic Nephropathies |
|
Estradiol |
3.88 | 19279558 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
3.02 | 12083418 |
| MESH:D016889 |
Endometrial Neoplasms |
|
Estradiol |
3.28 | 19148513 18566989 11473722 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.31 | 20131406 19236843 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.81 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.76 | 18467677 16221962 19176532 19772884 |
| MESH:D006558 |
Herpes Genitalis |
|
Estradiol |
6.10 | 15709030 |
| MESH:D019584 |
Hot Flashes |
|
Estradiol |
4.82 | 17088409 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.69 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
Estradiol |
8.19 | 16627594 16393666 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
8.19 | 16306350 |
| MESH:D007674 |
Kidney Diseases |
|
Estradiol |
2.83 | 15618244 |
| MESH:D007680 |
Kidney Neoplasms |
|
Estradiol |
3.41 | 15610895 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Estradiol |
2.40 | 14659978 14716833 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
2.40 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.95 | 15890375 20007298 16377806 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Estradiol |
2.85 | 17203775 11807958 11408345 16891317 |
| MESH:D020149 |
Manganese Poisoning |
|
Estradiol |
5.55 | 19453300 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.27 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.30 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
Estradiol |
9.55 | 16810080 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
9.55 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.14 | 17405874 |
| MESH:D009389 |
Neovascularization, Pathologic |
|
Estradiol |
4.62 | 17289903 |
| MESH:D009421 |
Nervous System Malformations |
|
Estradiol |
4.32 | 11399458 16427766 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.90 | 20558911 |
| MESH:D010051 |
Ovarian Neoplasms |
|
Estradiol |
2.33 | 19401270 |
| MESH:D019048 |
Prostatic Intraepithelial Neoplasia |
|
Estradiol |
4.44 | 20887781 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Estradiol |
3.01 | 16740699 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.58 | 19058328 |
| MESH:D013978 |
Tibial Fractures |
|
Estradiol |
5.76 | 19048282 |
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