AutismKB 2.0

Annotation Detail for ZNF398


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Basic Information Top
Gene Symbol:ZNF398 ( KIAA1339,P51,P71,ZER6 )
Gene Full Name: zinc finger protein 398
Band: 7q35
Quick LinksEntrez ID:57541; OMIM: NA; Uniprot ID:ZN398_HUMAN; ENSEMBL ID: ENSG00000197024; HGNC ID: 18373
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ZNF398 mRNAaffects cotreatment|increases expression 17183730
D007213 Indomethacin Indomethacin results in decreased expression of ZNF398 mRNAdecreases expression 16984733
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ZNF398 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.4119490988
MESH:D000230 Adenocarcinoma Indomethacin 2.8616537180
MESH:D000236 Adenoma Indomethacin 3.6811497255
MESH:D016301 Alveolar Bone Loss Indomethacin 6.2417225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7717627676 15579461
MESH:D000550 Amblyopia Valproic Acid 6.1017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9417497229
MESH:D001014 Aortic Aneurysm Indomethacin 5.4310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.5210388637
MESH:D018771 Arthralgia Indomethacin 6.042160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.9011248219
MESH:D001321 Autistic Disorder Valproic Acid 1.9817507914 18396377 17157402 18558336 18316065 19232924 18177632 18775368 17688650 16609825 20603192 19460635 18985861 18940202 15238991
MESH:D001477 Bartter Syndrome Indomethacin 5.6410684365
MESH:D001714 Bipolar Disorder Valproic Acid 3.2620046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.668888407
MESH:D001929 Brain Edema Indomethacin 5.8911481608
MESH:D002545 Brain Ischemia Indomethacin 5.1612524144
MESH:D001943 Breast Neoplasms Indomethacin 2.7917401462
MESH:D002056 Burns Indomethacin 5.3610459503
MESH:D002100 Cachexia Indomethacin 5.7515625704 16537180 15141370 11239499
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 2.4816391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.4711053908
MESH:D018276 Carcinoma, Medullary Indomethacin 6.0911352223 18791128 14736730
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.5417341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9412636206 15482327
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8320734317
MESH:D002764 Cholecystitis Indomethacin 6.0411181007
MESH:D003110 Colonic Neoplasms Indomethacin 2.6415936596 15625704 11260862 15637740 15963497 15786552
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 11197048 17054584 18059344
MESH:D018352 Coronavirus Infections Indomethacin 6.5817302372
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.918888407 17688650 16575769
MESH:D003967 Diarrhea Indomethacin 4.377237001 7907874
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.261733752 19641884
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.8912774134 18446180 16326151 16133044 17190690 18043480
MESH:D004381 Duodenal Ulcer Indomethacin 4.7211991626 17151854 11535926 17045617 17351913 11595415 10671773 17329845 16699067 17202747 11595431
MESH:D004421 Dystonia Valproic Acid 4.581851702
MESH:D004487 Edema Indomethacin 3.9816100529 8273558 7990266 7907874 19703484 8985016 10653021
MESH:D004715 Endometriosis Indomethacin 4.5915652904
MESH:D019446 Endotoxemia Indomethacin 5.2418509659
MESH:D004751 Enteritis Indomethacin 5.6116328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.6417980183
MESH:D004802 Eosinophilia Indomethacin 4.7011298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.8117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.783922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 4.007562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.813659116
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8911005569
MESH:D005234 Fatty Liver Valproic Acid 3.7819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.7516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.7118558336 8888407
MESH:D005334 Fever Indomethacin 4.5610431976 17627676 11852909
MESH:D005354 Fibrosarcoma Indomethacin 5.6410962813
MESH:D005355 Fibrosis Indomethacin 4.7217994277
MESH:D005499 Folliculitis Indomethacin 6.0411298111
MESH:D005756 Gastritis Indomethacin 5.6115046732
MESH:D005909 Glioblastoma Indomethacin 3.8312870263
MESH:D005910 Glioma Indomethacin 3.3618371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.6511849393
MESH:D006073 Gout Indomethacin 6.0911248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 4.0215482327
MESH:D006501 Hepatic Encephalopathy Indomethacin 5.0615633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 5.2715135802
MESH:D006849 Hydrocephalus Valproic Acid 5.6117688650
MESH:D006930 Hyperalgesia Indomethacin 4.1312727271
MESH:D034321 Hyperamylasemia Indomethacin 6.5817883296
MESH:D006940 Hyperemia Indomethacin 5.7512524144
MESH:D006949 Hyperlipidemias Indomethacin 4.6917546600
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.2816612254
MESH:D007077 Ileal Diseases Indomethacin 5.8918306037 10574470
MESH:D007079 Ileitis Indomethacin 6.0916133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 6.2416133044
MESH:D007249 Inflammation Indomethacin 3.177812673 12568917 3291741
MESH:D007410 Intestinal Diseases Indomethacin 4.9815610444 15831440 10210152 11855677 17994277 11686837 11713966 18236018 17329856
MESH:D019586 Intracranial Hypertension Indomethacin 6.2415241188
MESH:D007579 Jejunal Diseases Indomethacin 5.8910574470 16133968 18306037
MESH:D007674 Kidney Diseases Indomethacin 3.4917190690
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.2911703811 10320625 12228301
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.2510785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.2918360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.2917596541 16294345
MESH:D007964 Leukocytosis Indomethacin 6.2416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.5817980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.5811479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.3718194892
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 5.1317228818
MESH:D008175 Lung Neoplasms Indomethacin 2.3716537180 11497255 11053908
MESH:D008881 Migraine Disorders Indomethacin 8.7611903285
MESH:D008881 Migraine Disorders Valproic Acid 8.7618803445 18765137
MESH:D009062 Mouth Neoplasms Indomethacin 4.3312636206
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.518888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3717596541
MESH:D009362 Neoplasm Metastasis Indomethacin 3.3011053908 11239499 16537180
MESH:D009374 Neoplasms, Experimental Indomethacin 4.7815625704 10663608
MESH:D009436 Neural Tube Defects Valproic Acid 3.3916359493 8888407
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.3312349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 6.046374098
MESH:D010003 Osteoarthritis Indomethacin 3.907009135
MESH:D010146 Pain Indomethacin 3.8417627676 3291741 17440234 13679232
MESH:D010149 Pain, Postoperative Indomethacin 5.5512538197 18702446
MESH:D010195 Pancreatitis Indomethacin 4.4517883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.5816537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.5612349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.5811903285
MESH:D010437 Peptic Ulcer Indomethacin 5.8911148446
MESH:D010518 Periodontitis Indomethacin 5.7817225004
MESH:D047928 Premature Birth Indomethacin 5.7817000239
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.5720603192
MESH:D011507 Proteinuria Indomethacin 4.6911849393
MESH:D019310 Pseudolymphoma Valproic Acid 5.4112752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.7019155313
MESH:D012559 Schizophrenia Valproic Acid 2.1115737665 19110320
MESH:D012640 Seizures Valproic Acid 3.023137016 11738929 1511512 14763951 17978042 11044598 15475178 16876388
MESH:D016135 Spinal Dysraphism Valproic Acid 4.1319490988
MESH:D013226 Status Epilepticus Valproic Acid 5.4112833885
MESH:D013272 Stomach Diseases Indomethacin 5.1618209964 16113693 17160473 17207306 15472012 10215738 10486359 18545984 10192188 17638125 16184426 16280098 15038085
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 4.061323529 16252198 18209962 11145282 12787963 17135157 17654042 16150113 10878458 12500499 17918041 16755016 16631530 16397915 17977527 18087811 17895592 12498302 18726076 10750652 10423059 17627676 18181030 11523592 11729361 12467913 18299717 14567935 16934674 15104355 15255614 17657623 11595415 15138204 16169175 11595431 12077510 11906479 18193104 18431645 18237397 18543354
MESH:D013964 Thyroid Neoplasms Indomethacin 3.9211352223 18791128 14736730
MESH:D014178 Translocation, Genetic Valproic Acid 6.1017262798
MESH:D014456 Ulcer Indomethacin 5.6417380554 10574470
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.263119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.308888407
MESH:D014839 Vomiting Indomethacin 5.6111897121
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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