AutismKB 2.0

Annotation Detail for TAOK1


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Basic Information Top
Gene Symbol:TAOK1 ( FLJ14314,KIAA1361,MAP3K16,MARKK,PSK2,TAO1 )
Gene Full Name: TAO kinase 1
Band: 17q11.2
Quick LinksEntrez ID:57551; OMIM: 610266; Uniprot ID:TAOK1_HUMAN; ENSEMBL ID: ENSG00000160551; HGNC ID: 29259
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200014p38 MAPK signaling pathway
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
mean platelet volume
Desease Name
Mean platelet volume
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TAOK1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TAOK1 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of TAOK1 mRNAdecreases expression 18929588
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TAOK1 mRNAdecreases expression 19150397
D002118 Calcium Calcium affects the expression of TAOK1 mRNAaffects expression 15913539
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TAOK1 mRNAaffects expression 17555576
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TAOK1 mRNAincreases expression 19285098
C052785 rebamipide rebamipide results in increased expression of TAOK1 mRNAincreases expression 15104358
D013629 Tamoxifen Tamoxifen affects the expression of TAOK1 mRNAaffects expression 17555576
C025643 vinclozolin vinclozolin affects the expression of TAOK1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 5.4815146954
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001943 Breast Neoplasms Tamoxifen 2.1916273361 19221464 19103187 21138602 18984771 19011961 20005174 19115204 17242785 15668708 20135344 17893378 19066611 17261762 16818667 19200415 19289846 16873071 20065188 18351453 18425577 18815881 20390343 19288272 19059307 19142967 11161223 20859285 21152245 19189210 18821012 15565566 18997820 19487384 19244106 18629630 19155303 19410462 18855134 19189212 17049068 16202921 20544844 19084267 17440819
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0516705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.036135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017333356 16919318 17110522 11677210 15861022 17681005 16105132
MESH:D003110 Colonic Neoplasms arsenite 2.6115037631
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0118551238 21346803
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1520544844 19155303 17893378 16202921
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver arsenite 14.2018296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2015345470
MESH:D005234 Fatty Liver Tamoxifen 14.2019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis arsenite 4.2818296743
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0317937319
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Tamoxifen 2.4319457130
MESH:D007410 Intestinal Diseases rebamipide 5.3911686837
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.8718625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.3116316344
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.5018296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7418564211
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.747678174
MESH:D008113 Liver Neoplasms Tamoxifen 4.7416684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.642876786 6135515 2876784
MESH:D008175 Lung Neoplasms arsenite 2.7016809336
MESH:D008175 Lung Neoplasms Tamoxifen 2.7018625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7311731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic arsenite 4.6515738583
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010024 Osteoporosis Calcium 3.8817882678
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1215067354
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013272 Stomach Diseases rebamipide 5.5116184426
MESH:D013274 Stomach Neoplasms rebamipide 3.2115993841
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2316049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2317572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134872946
    • No data
    Releated disease ID Related disease Name
    PA443670Cerebral Infarction
    PA444613Infarction
    PA445019Myocardial Infarction
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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