AutismKB 2.0

Annotation Detail for MICAL3


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Basic Information Top
Gene Symbol:MICAL3 ( KIAA0819,MGC189703 )
Gene Full Name: microtubule associated monoxygenase, calponin and LIM domain containing 3
Band: 22q11.21
Quick LinksEntrez ID:57553; OMIM: 608882; Uniprot ID:MICA3_HUMAN; ENSEMBL ID: ENSG00000093100,ENSG00000243156; HGNC ID: 24694
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MICAL3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MICAL3 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MICAL3 mRNAincreases expression 17484886
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of MICAL3 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of MICAL3 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 17688650 18316065 18775368 15238991 18177632 20603192 19460635 17157402 19232924 16609825 18940202 18558336 18985861 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2615673190 16192424 15700767 16097048 15721981 3786805 16227642 10355542 18705752 16011737 16050911 16124888
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9718788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7119420014 14986274 16781746 16227642 16393943 17522070 11529661 17906064 10663392 19416960 19370779 12705907 11739529 11421492 17562736 16109766 11743745 16177239 15619225 15968718 16485898 11834606 10774834 10915739 14550746 11461765 18713872 12958197 14725611 16081117 12153990 19923254 12392966 19164858 12540782 12594235 19085960 18071297 11287661 19739265 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.713732212 4309450 19336974 6884620 15027814 17522070 19085960 7440962 7120509 2869522 6623471 7179309 15968718 21278145 3786805 10915739 11566570 16227642 16177239 9327722 15998439 10092053
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.711733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.1412631006 16239168 12795759 61145 16045604 15959796 19224547 17595544
MESH:D005234 Fatty Liver Valproic Acid 9.1419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1116612254
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816221502 11903743 16239168 11408273 21278145 16943688 17157831 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7512667390 18376398 18277467 18412020 18472332 12666154 17766677 17823541 18705752 18251166 16192424 14512876 12445421 15370692 17565644 17805973 17525996 17761835 20821823 18205269 15650968 18472094 18339082 17481882 15057751 17708605 18418968 14716496 18187930 18006644 11481614 15925388 12609069 17557913 17640975 17869086 16027843 17721639 18166357 12898905 18481824 13678700 15996030 16248980 18429990 14620537 18317297 15730626 17976157 12546737 17900296 18054572 18395095 15673190 18156304 12389079 15362042 17698563 15876570 15338365 14716833 18210741 15123356 17922224 14748882 16136751 12741479 12649538 12632512 15818738 16116963 18395914 10355542 12445418 12958196 16638106 17944888 18279442 15052691 17714472 14724832 12632514 12586293 15931870 15893842 16015684 17631135 16033810 16011737 18420326 16097048 15959796 18263696
MESH:D008107 Liver Diseases Acetaminophen 4.1411587558 19784758 12587719 16611625 16610002 19014921 12969438 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1415830285 17285989 16246199 15720792 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.5916871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.5916899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8819294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8112014681 15583823
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 6695378 18520028 20135361 18816296 20064080 18569708 20869020 17053015
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009436 Neural Tube Defects Valproic Acid 3.348888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D019310 Pseudolymphoma Valproic Acid 5.1511422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9617978042 16876388 11044598 11738929 14763951 15475178 1511512 3137016
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5119755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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