AutismKB 2.0

Annotation Detail for TWF1


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Basic Information Top
Gene Symbol:TWF1 ( A6,MGC23788,MGC41876,PTK9 )
Gene Full Name: twinfilin, actin-binding protein, homolog 1 (Drosophila)
Band: 12q12
Quick LinksEntrez ID:5756; OMIM: 610932; Uniprot ID:TWF1_HUMAN; ENSEMBL ID: ENSG00000151239; HGNC ID: 9620
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TWF1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TWF1 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TWF1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TWF1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TWF1 mRNAdecreases expression 20018196
D004041 Dietary Fats Dietary Fats results in decreased expression of TWF1 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TWF1 mRNAincreases expression 17557909
C011890 kojic acid kojic acid results in decreased expression of TWF1 mRNAdecreases expression 16595896
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TWF1 mRNAincreases expression 17616710
C041786 palm oil palm oil results in decreased expression of TWF1 mRNAdecreases expression 18042831
D014750 Vincristine TWF1 protein affects the susceptibility to Vincristineaffects response to substance 19783987
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.9614692618
MESH:D000230 Adenocarcinoma Vincristine 4.9619825857
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.6415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.2720435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D002292 Carcinoma, Renal Cell Vincristine 4.4216201981
MESH:D002294 Carcinoma, Squamous Cell Vincristine 3.876189445
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.036135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0016105132 15861022 11677210 17110522 17681005 17333356 16919318
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4416109766 14725611 16485898 11287661 19420014 19739265 15968718 11743745 15619225 19416960 19085960 11461765 10774834 18071297 12153990 16781746 19923254 11739529 16177239 10915739 2444490 11529661 11834606 12705907 12540782 12594235 12958197 17522070 16227642 11421492 19164858 12392966 10663392 16081117 16393943 18713872 19370779 17906064 17562736 14550746 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7620426865
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7615264214 15547721 15150132 16510608 16805852 16704527 15547733 15623463 15878914
MESH:D005234 Fatty Liver Dietary Fats 8.3018296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3015345470
MESH:D005355 Fibrosis Dietary Fats 3.7418296743
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006689 Hodgkin Disease Vincristine 4.7515147373 17606976 16794504 16135485
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2111836018 18457598
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8516705839
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 12969438 19460945 16611625 19784758 16610002 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.217678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.522876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.5218544905
MESH:D008175 Lung Neoplasms Vincristine 3.3419825857 6189445
MESH:D008223 Lymphoma marker/mechanism 19783987
MESH:D018328 Melanoma, Amelanotic Vincristine 6.0215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009203 Myocardial Infarction Vincristine 4.2017284715
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D017599 Neuroectodermal Tumors Vincristine 5.9412837982
MESH:D009765 Obesity Dietary Fats 2.3220132043 19632207 18457598 18674790 11836018 21332399 16723640 17217161 20518802
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.7121297632
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3317575124 12958204
MESH:D015173 Supratentorial Neoplasms Vincristine 6.1112837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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