AutismKB 2.0

Annotation Detail for ARRDC3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARRDC3 ( KIAA1376,TLIMP )
Gene Full Name: arrestin domain containing 3
Band: 5q14.3
Quick LinksEntrez ID:57561; OMIM: 612464; Uniprot ID:ARRD3_HUMAN; ENSEMBL ID: ENSG00000113369; HGNC ID: 29263
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARRDC3 mRNAincreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of ARRDC3 mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen affects the expression of ARRDC3 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of ARRDC3 mRNAincreases expression 20458559
D004041 Dietary Fats Dietary Fats results in decreased expression of ARRDC3 mRNAdecreases expression 18042831
D000431 Ethanol Ethanol results in decreased expression of ARRDC3 mRNAdecreases expression 16098508
D007213 Indomethacin Indomethacin results in increased expression of ARRDC3 mRNAincreases expression 16984733
D007501 Iron Iron deficiency results in increased expression of ARRDC3 mRNAincreases expression 20368581
C041786 palm oil palm oil results in decreased expression of ARRDC3 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of ARRDC3 mRNAincreases expression 19270015
D010656 Phenylephrine Phenylephrine results in decreased expression of ARRDC3 mRNAdecreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARRDC3 mRNAaffects binding|decreases expression|increases activity 19710929
D013467 Sulindac Sulindac results in increased expression of ARRDC3 mRNAincreases expression 11906190
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARRDC3 mRNAincreases expression 19933214
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of ARRDC3 mRNAdecreases expression 16330358
C025643 vinclozolin vinclozolin affects the expression of ARRDC3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.5314745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 14.3818926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 14.386195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.3811752688 14514962 15322242
MESH:D000138 Acidosis Ethanol 4.5211192467
MESH:D058186 Acute Kidney Injury Sulindac 4.327897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.3219825857 11798837
MESH:D000230 Adenocarcinoma Indomethacin 7.3216537180
MESH:D000230 Adenocarcinoma Sulindac 7.3211910360
MESH:D000236 Adenoma Indomethacin 7.2711497255
MESH:D000236 Adenoma Sulindac 7.2710223192
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.4217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4216835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.6011535846 12394442 19003578 17611924 11874996 15623613 16460482
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.3515451039 15451040
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.6716640825
MESH:D016301 Alveolar Bone Loss Indomethacin 5.4017225004
MESH:D000544 Alzheimer Disease Indomethacin 4.6415579461 17627676
MESH:D000544 Alzheimer Disease Iron 4.6416640825 16563566
MESH:D000740 Anemia Iron 8.9316566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9311748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.6517147795 17163184 16569441 17375513 17162259
MESH:D000756 Anemia, Sideroblastic Iron 4.8216910769
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D000853 Anophthalmos Ethanol 4.8315513904
MESH:D001008 Anxiety Disorders Ethanol 9.0211141031
MESH:D001008 Anxiety Disorders vinclozolin 9.0219015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.8610231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8810388637
MESH:D001145 Arrhythmias, Cardiac Iron 9.3616604332
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 9.3617460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.9015238619
MESH:D018771 Arthralgia Indomethacin 5.202160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8211248219
MESH:D001260 Ataxia Telangiectasia Iron 5.4715336622
MESH:D050197 Atherosclerosis Iron 3.7116640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.2116640825
MESH:D001477 Bartter Syndrome Indomethacin 5.0010684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.3116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001913 Bowen's Disease Sulindac 5.3811207687
MESH:D001919 Bradycardia Phenylephrine 4.5615306635
MESH:D001929 Brain Edema Indomethacin 5.0611481608
MESH:D002545 Brain Ischemia Indomethacin 4.4412524144
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.3711921183
MESH:D001943 Breast Neoplasms Dietary Fats 2.3720435547
MESH:D001943 Breast Neoplasms Indomethacin 2.3717401462
MESH:D001943 Breast Neoplasms Sulindac 2.3716642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D002056 Burns Ethanol 11.4316374292
MESH:D002056 Burns Indomethacin 11.4310459503
MESH:D002100 Cachexia Indomethacin 5.0215141370 16537180 11239499 15625704
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.903084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.9015553829 14691202 16217749 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.9015289165 18788625 15763234
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.9016391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.901701930 6705139 20007298 17173139 20935162
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.7511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.3714736730 11352223 18791128
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3717341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8512636206 15482327
MESH:D006332 Cardiomegaly Ethanol 11.5019332462
MESH:D006332 Cardiomegaly Phenylephrine 11.5015728586 11179087 17287366 17124262 11754973 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.5018850075 16120746 18670907
MESH:D009202 Cardiomyopathies Iron 4.0416640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4616604332
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002764 Cholecystitis Indomethacin 5.2011181007
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D002971 Cleft Lip Ethanol 3.5815513904
MESH:D002972 Cleft Palate Ethanol 5.9515513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.958697196 15668235 15340226 16354765 12621046
MESH:D003110 Colonic Neoplasms Indomethacin 6.1015625704 15786552 15637740 15936596 11260862 15963497
MESH:D003110 Colonic Neoplasms Iron 6.1016640825
MESH:D003110 Colonic Neoplasms Sulindac 6.1012458338 12902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.6020501625
MESH:D015179 Colorectal Neoplasms Indomethacin 3.6012606626 11197048 18059344 17054584
MESH:D015179 Colorectal Neoplasms Sulindac 3.6011197048 10666051 11076880 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D018352 Coronavirus Infections Indomethacin 5.7517302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8310525206
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8310194807 11873399 19302082 15513904 11198716 15451040 15451039
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8315322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003920 Diabetes Mellitus Iron 4.4516604332 16640825
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.3716684804
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3616506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.5516506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5517107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.1912861449 17621415
MESH:D003967 Diarrhea Indomethacin 3.807237001 7907874
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2112153990 15968718 14550746 12594235 19416960 19923254 11461765 16109766 11743745 2444490 19739265 16485898 11529661 19164858 10663392 16393943 12540782 17562736 18713872 16177239 14725611 11739529 17522070 19085960 16781746 16081117 11421492 12392966 12958197 19370779 12705907 19420014 17906064 15619225 10915739 10774834 14986274 18071297 11287661 11834606 16227642
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.2111566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.1716133044 17190690 16326151 18043480 18446180 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.1411595415 11535926 17351913 11595431 10671773 17202747 11991626 17045617 17329845 17151854 16699067
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:D004487 Edema Indomethacin 11.487990266 19703484 8273558 16100529 8985016 7907874 10653021
MESH:D004487 Edema pirinixic acid 11.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9315322242 16714409 18230668
MESH:D004715 Endometriosis Indomethacin 15.4315652904
MESH:D004715 Endometriosis Sulindac 15.4315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 15.4310568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.5218509659
MESH:D004751 Enteritis Indomethacin 4.7816328016 17763956 10567023
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.0017980183
MESH:D004802 Eosinophilia Indomethacin 4.0711298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.903922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.5112903497
MESH:D004938 Esophageal Neoplasms Ethanol 10.5116704527
MESH:D004938 Esophageal Neoplasms Indomethacin 10.5111005569
MESH:D004938 Esophageal Neoplasms Sulindac 10.5112235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver arsenic trioxide 24.7515073043
MESH:D005234 Fatty Liver Dietary Fats 24.7519551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver Ethanol 24.7516409862 19236843 18620774
MESH:D005234 Fatty Liver Iron 24.7516640825
MESH:D005234 Fatty Liver pirinixic acid 24.7520131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.7017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.3216946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005334 Fever Indomethacin 4.1217627676 10431976 11852909
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.5014745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.1519069698
MESH:D005354 Fibrosarcoma Indomethacin 4.9110962813
MESH:D005355 Fibrosis Dietary Fats 14.9318296743
MESH:D005355 Fibrosis Indomethacin 14.9317994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.9320067830
MESH:D005499 Folliculitis Indomethacin 5.2011298111
MESH:D005621 Friedreich Ataxia Iron 5.4416604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D005756 Gastritis Acetaminophen 19.2516983495
MESH:D005756 Gastritis Ethanol 19.2515046732
MESH:D005756 Gastritis Indomethacin 19.2515046732
MESH:D005764 Gastroesophageal Reflux Sulindac 5.0211910360
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005909 Glioblastoma Indomethacin 3.5612870263
MESH:D005910 Glioma Indomethacin 3.2316487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2911849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006073 Gout Indomethacin 5.3711248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7415482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006432 Hemochromatosis Iron 4.4917236123 17255318 16640825 17053826 16604332 16574947
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006486 Hemosiderosis Iron 5.2416604332
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5715633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6915135802
MESH:D006525 Hepatitis, Viral, Human Iron 5.5016640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.9517182432
MESH:D006529 Hepatomegaly Iron 20.8516890145
MESH:D006529 Hepatomegaly Phenobarbital 20.8516109766
MESH:D006529 Hepatomegaly pirinixic acid 20.8516221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.8515340226 16120746 12621046
MESH:D015658 HIV Infections Iron 3.6716597321
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0818606429 16354765 15340226 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 13.1616870215
MESH:D006930 Hyperalgesia Ethanol 13.1618783367
MESH:D006930 Hyperalgesia Indomethacin 13.1612727271
MESH:D034321 Hyperamylasemia Indomethacin 5.7517883296
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D006940 Hyperemia Indomethacin 5.0212524144
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006949 Hyperlipidemias Dietary Fats 9.3621332399
MESH:D006949 Hyperlipidemias Indomethacin 9.3617546600
MESH:D006973 Hypertension Phenylephrine 5.3112717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.5612791704 18502941
MESH:D007006 Hypogonadism Iron 4.4016640825
MESH:D007037 Hypothyroidism Iron 5.0916640825
MESH:D007077 Ileal Diseases Indomethacin 5.0610574470 18306037
MESH:D007079 Ileitis Indomethacin 5.3710647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.4016133044
MESH:D007248 Infertility, Male vinclozolin 3.0416467254
MESH:D007249 Inflammation Dietary Fats 12.0420412841
MESH:D007249 Inflammation Indomethacin 12.047812673 3291741 12568917
MESH:D007249 Inflammation Sulindac 12.043291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.0412878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.2511836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.2516306350
MESH:D007410 Intestinal Diseases Indomethacin 4.3411855677 11713966 17994277 15831440 11686837 18236018 15610444 17329856 10210152
MESH:D007414 Intestinal Neoplasms Sulindac 4.6412584176 10213222 12351151 12628509 10223192 12663524
MESH:D007417 Intestinal Polyps Sulindac 4.9911245490 12394442
MESH:D019586 Intracranial Hypertension Indomethacin 5.4015241188
MESH:D019189 Iron Metabolism Disorders Iron 5.0417163184
MESH:D007569 Jaw Abnormalities Ethanol 10.1415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1416580747
MESH:D007579 Jejunal Diseases Indomethacin 5.0616133968 18306037 10574470
MESH:D007674 Kidney Diseases Acetaminophen 6.1415629191 12587719
MESH:D007674 Kidney Diseases Indomethacin 6.1417190690
MESH:D007859 Learning Disorders Ethanol 4.2215451040
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9012228301 10320625 11703811
MESH:D007938 Leukemia arsenic trioxide 2.8315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.5614633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.5616572323 10785260 15631656
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0916467208 19850784 20471514 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.0918360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2216891316 11468182 15213294 16112521 16966277 19075265 19225113 16823087 12679006 17107899 11161223 19035177 15622746 19642359 15748426 17649720 12018890 17869043 16331271 17217047 12712474 15336539 16330433 9834237 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D007964 Leukocytosis Indomethacin 5.4016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.7517980183
MESH:D020961 Lewy Body Disease Iron 5.4416563566
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8117676605
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.7511479899
MESH:D008103 Liver Cirrhosis Dietary Fats 15.8418296743
MESH:D008103 Liver Cirrhosis Ethanol 15.8415289165
MESH:D008103 Liver Cirrhosis Iron 15.8416640825
MESH:D008103 Liver Cirrhosis Phenobarbital 15.8421047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.1218295389
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.2212468960
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.9818166357
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.9818194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9812878042
MESH:D008107 Liver Diseases Acetaminophen 6.6219784758 16611625 19460945 12587719 12969438 11587558 19014921 16610002
MESH:D008107 Liver Diseases Phenobarbital 6.6219363144
MESH:D008107 Liver Diseases Sulindac 6.6216867024 14986274
MESH:D008108 Liver Diseases, Alcoholic Ethanol 11.5417207112 17347304
MESH:D008108 Liver Diseases, Alcoholic Iron 11.5417207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 14.2614682389
MESH:D008113 Liver Neoplasms Iron 14.2620302851 16640825
MESH:D008113 Liver Neoplasms Phenobarbital 14.2621047994 19812893 19482888 15975961 8742319 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.2615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.8320377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.8317172636 1399818 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008175 Lung Neoplasms arsenic trioxide 6.6319825857 11798837
MESH:D008175 Lung Neoplasms Indomethacin 6.6316537180 11497255 11053908
MESH:D008175 Lung Neoplasms Iron 6.6316640825
MESH:D008175 Lung Neoplasms Sulindac 6.6319359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6319555203 11884234
MESH:D008268 Macular Degeneration Iron 3.9816640825
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.5811921183
MESH:D008545 Melanoma Sulindac 2.8316642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008569 Memory Disorders Ethanol 4.2018411066 15451040
MESH:D008881 Migraine Disorders Indomethacin 3.6711903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.9912636206
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1119417148 19549372 14977855 15949261 11468182
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.7017086897
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009181 Mycoses Iron 5.5016640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1416882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Iron 9.1816604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.1812213967
MESH:D015428 Myocardial Reperfusion Injury Iron 8.6216604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009362 Neoplasm Metastasis Indomethacin 3.1711239499 11053908 16537180
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.1510663608 15625704
MESH:D009404 Nephrotic Syndrome Iron 4.5217178036
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 20.2018514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 20.2012349958
MESH:D019636 Neurodegenerative Diseases Iron 20.2017296847 16604332
MESH:D019636 Neurodegenerative Diseases Sulindac 20.2016850258 17266991
MESH:D009765 Obesity Dietary Fats 4.4419632207 20132043 17217161 20518802 21332399 11836018 18674790 16723640 18457598
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.206374098
MESH:D010003 Osteoarthritis Indomethacin 7.997009135
MESH:D010003 Osteoarthritis Iron 7.9916640825
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010024 Osteoporosis Iron 3.8616640825 16648989
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4112452020 16624393 19769630
MESH:D010146 Pain Acetaminophen 11.4116870215
MESH:D010146 Pain Indomethacin 11.413291741 17440234 13679232 17627676
MESH:D010146 Pain Sulindac 11.413291741
MESH:D010149 Pain, Postoperative Indomethacin 4.7118702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.4115580305
MESH:D010190 Pancreatic Neoplasms Ethanol 12.4112384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 12.4116965848
MESH:D010190 Pancreatic Neoplasms Sulindac 12.4111504793 16820089
MESH:D010195 Pancreatitis Indomethacin 3.9315028970 17883296
MESH:D010212 Papilloma Iron 4.5012065085
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.7516537180
MESH:D020447 Parasomnias Iron 6.0517352947
MESH:D010300 Parkinson Disease Iron 3.3216640825 16563566
MESH:D020734 Parkinsonian Disorders Indomethacin 4.1212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.7511903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010437 Peptic Ulcer Indomethacin 5.1711148446
MESH:D010518 Periodontitis Indomethacin 4.9417225004
MESH:D010900 Pituitary Diseases Iron 5.7016604332
MESH:D011041 Poisoning Iron 4.3016604332
MESH:D017119 Porphyria Cutanea Tarda Iron 11.0516640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.0518163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.622563599
MESH:D011225 Pre-Eclampsia Iron 4.4216640825
MESH:D047928 Premature Birth Indomethacin 5.1417000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.5619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2819131511
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011507 Proteinuria Indomethacin 4.1711849393
MESH:D011528 Protozoan Infections Iron 6.0516640825
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012148 Restless Legs Syndrome Iron 4.5516930377
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012640 Seizures Ethanol 6.169754883
MESH:D012640 Seizures Phenobarbital 6.164039156 16876388 3137016 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D012852 Sinusitis Phenylephrine 4.727327846
MESH:D012878 Skin Neoplasms Iron 5.8812065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8816192470
MESH:D013272 Stomach Diseases Indomethacin 4.4417638125 17160473 16113693 18209964 16184426 10192188 18545984 10486359 16280098 10215738 15038085 15472012 17207306
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5217007042
MESH:D013274 Stomach Neoplasms Ethanol 3.5218456281
MESH:D013274 Stomach Neoplasms Indomethacin 3.5215609394
MESH:D013276 Stomach Ulcer Ethanol 7.6017918041 9562338 11906479 17189318 16755016 9211565
MESH:D013276 Stomach Ulcer Indomethacin 7.6012498302 16252198 18209962 16755016 11729361 18543354 18299717 1323529 17657623 15138204 18087811 12500499 11595415 11523592 11595431 11145282 16169175 15104355 16934674 12077510 18193104 16397915 12467913 17627676 14567935 15255614 16631530 18431645 10423059 17135157 12787963 18237397 11906479 10878458 17895592 16150113 17654042 10750652 17918041 17977527 18181030 18726076
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.269754883
MESH:D013398 Sudden Infant Death Iron 5.4716640825
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.0819014326
MESH:D013964 Thyroid Neoplasms Indomethacin 12.0814736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.081399818
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014376 Tuberculosis Iron 4.0916597321
MESH:D014456 Ulcer Indomethacin 4.9110574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.4812845720 20435036 12973940 11780464
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Sulindac 4.6118645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D014839 Vomiting Indomethacin 4.7811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved