AutismKB 2.0

Annotation Detail for KLHL8


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Basic Information Top
Gene Symbol:KLHL8 ( FLJ46304,KIAA1378 )
Gene Full Name: kelch-like 8 (Drosophila)
Band: 4q22.1
Quick LinksEntrez ID:57563; OMIM: 611967; Uniprot ID:KLHL8_HUMAN; ENSEMBL ID: ENSG00000145332; HGNC ID: 18644
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KLHL8 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of KLHL8 mRNAdecreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLHL8 mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KLHL8 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of KLHL8 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of KLHL8 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLHL8 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KLHL8 mRNAdecreases expression 17101203
D014635 Valproic Acid Valproic Acid results in increased expression of KLHL8 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9917157402 19232924 18775368 18985861 18940202 18558336 16609825 15238991 17688650 20603192 18177632 19460635 18396377 17507914 18316065
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.043786805 15700767 18705752 16227642 16192424 15673190 16124888 15721981 16050911 16097048 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.727296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7218788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.986135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.987505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 15340226 12621046 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5217688650 8888407 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 8156756 8970840 12868966 11906362 18759878 14531868 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.5918692083 9328219 18289764 6679447 1440618 9653073 9022650 16192314 6482804 8291058 18648102 7440962 11289319
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.5915027814 4309450 3732212 9327722 7179309 16177239 6884620 10915739 15998439 17522070 10092053 7440962 6623471 19085960 11566570 21278145 7120509 16227642 3786805 15968718 19336974 2869522
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.591733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.543581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5612795759 19224547 15959796 61145 12631006 16045604 16239168 17595544
MESH:D005234 Fatty Liver Dietary Fats 20.5617967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 20.5619236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 20.5619224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Carbon Tetrachloride 16.3418705752
MESH:D005355 Fibrosis Dietary Fats 16.3418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.3420067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.036705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.1419772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16354765 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007249 Inflammation Dietary Fats 5.2420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2412878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.6718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9711408273 17157831 16943688 21278145 16221502 11903743 17174718 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9718296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5010355542 16638106 15996030 16136751 16116963 15730626 17976157 17869086 15876570 14620537 18705752 15818738 18263696 18006644 18279442 17481882 17525996 17761835 18418968 15925388 17766677 17805973 17900296 17698563 15650968 12389079 12898905 15931870 20821823 18472332 18166357 14512876 16027843 15370692 15362042 12666154 18395095 17823541 17944888 15338365 16033810 18277467 14724832 14748882 12546737 12649538 17557913 17922224 18156304 18472094 18317297 15673190 16011737 17708605 12445421 14716496 12609069 16248980 12741479 12445418 18187930 16015684 15893842 18210741 18205269 18054572 11481614 12632514 12632512 18376398 17565644 18251166 17640975 18395914 17721639 17714472 14716833 18412020 18429990 18339082 16192424 15959796 12586293 18420326 15123356 12958196 13678700 15052691 12667390 18481824 17631135 16097048 15057751
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216964402 16246199 17285989 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8816899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.247678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2419294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.2416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.122876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.12598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.1212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.1212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.686679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.6816359493 8888407
MESH:D009765 Obesity Dietary Fats 4.5817217161 19632207 21332399 18457598 18674790 16723640 20518802 11836018 20132043
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.546482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012640 Seizures Valproic Acid 6.3914763951 15475178 3137016 11738929 11044598 17978042 1511512 16876388
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.041399818 6587162 3712494 6582329 7505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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