AutismKB 2.0

Annotation Detail for PTMA


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Basic Information Top
Gene Symbol:PTMA ( MGC104802,TMSA )
Gene Full Name: prothymosin, alpha
Band: 2q37.1
Quick LinksEntrez ID:5757; OMIM: 188390; Uniprot ID:PTMA_HUMAN; ENSEMBL ID: ENSG00000187514; HGNC ID: 9623
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200045Validated targets of C-MYC transcriptional activation
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1943Adenocarcinoma
Desease Name
height
DEVELOPMENTAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PTMA mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PTMA mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PTMA mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTMA mRNAaffects expression 16483693
C032036 bromobenzene bromobenzene results in increased expression of PTMA mRNAincreases expression 12628495
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PTMA mRNAdecreases expression 12419474
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PTMA mRNAincreases expression 17522070
D002725 Chloroform Chloroform results in increased expression of PTMA mRNAincreases expression 17522070
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTMA mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTMA mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PTMA mRNAincreases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PTMA mRNAincreases expression 15766595
D004958 Estradiol Estradiol results in increased expression of PTMA mRNAincreases expression 9169520
D004958 Estradiol Estradiol results in increased expression of PTMA mRNAincreases expression 17522070
D000431 Ethanol Ethanol results in decreased expression of PTMA mRNAdecreases expression 17920746
D000431 Ethanol Ethanol results in increased expression of PTMA mRNAincreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PTMA mRNAdecreases expression 16872691
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PTMA mRNAincreases expression 17606305
C424943 glutamyl-Se-methylselenocysteine glutamyl-Se-methylselenocysteine results in increased expression of PTMA mRNAincreases expression 11306469
D005978 Glutathione PTMA protein alternative form results in increased abundance of Glutathioneincreases abundance 19442654
D005978 Glutathione PTMA protein alternative form results in decreased abundance of Glutathionedecreases abundance 19442654
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PTMA mRNAaffects cotreatment|increases expression 17183730
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased expression of PTMA mRNAdecreases expression 16052530
D009270 Naloxone Naloxone results in decreased expression of PTMA mRNAdecreases expression 17522070
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of PTMA mRNAincreases expression 17522070
D010269 Paraquat Paraquat affects the expression of PTMA mRNAaffects expression 15206577
D011802 Quinidine Quinidine results in decreased expression of PTMA mRNAdecreases expression 17522070
D017382 Reactive Oxygen Species PTMA protein alternative form results in decreased abundance of Reactive Oxygen Speciesdecreases abundance 19442654
D017382 Reactive Oxygen Species PTMA protein alternative form results in increased abundance of Reactive Oxygen Speciesincreases abundance 19442654
C017947 sodium arsenite sodium arsenite results in increased expression of PTMA mRNAincreases expression 11241755
C004648 testosterone enanthate testosterone enanthate affects the expression of PTMA mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PTMA mRNAdecreases expression 16054898
D013752 Tetracycline Tetracycline results in increased expression of PTMA mRNAincreases expression 17522070
D013806 Theophylline Theophylline results in decreased expression of PTMA mRNAdecreases expression 17522070
D014212 Tretinoin Tretinoin results in decreased expression of PTMA mRNAdecreases expression 17218384
D014501 Uranium Uranium affects the expression of PTMA mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of PTMA mRNAaffects expression 15672453
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PTMA mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.4617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.4611752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6519490988
MESH:D000138 Acidosis Ammonium Chloride 9.4318287403
MESH:D000138 Acidosis Ethanol 9.4311192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D000230 Adenocarcinoma Estradiol 3.9411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9414692618
MESH:D000236 Adenoma therapeutic 10822126
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.073712494
MESH:D000236 Adenoma Diethylnitrosamine 6.0710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.0217162532 19061943 18056438 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5917306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4611874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0015451040 15451039
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000550 Amblyopia Valproic Acid 4.9217688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D000853 Anophthalmos Ethanol 4.5215513904
MESH:D001008 Anxiety Disorders Ethanol 8.1811141031
MESH:D001008 Anxiety Disorders Valproic Acid 8.1817497229
MESH:D001145 Arrhythmias, Cardiac Quinidine 4.8918724381 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5715885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.5716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Theophylline 5.0712113382 9701106
MESH:D001249 Asthma Tretinoin 5.0716456186
MESH:D001321 Autistic Disorder Acetaminophen 2.1818445737
MESH:D001321 Autistic Disorder Glutathione 2.1818929414 16917939 19267885 19056591
MESH:D001321 Autistic Disorder Valproic Acid 2.1818316065 18396377 20603192 18985861 17507914 18558336 15238991 19232924 18177632 16609825 18940202 18775368 17157402 17688650 19460635
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7011289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.9220046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.0216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.368888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8117474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.8117129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.8117261762 14630087 17289903 17018787 19861407 18497071 12948864 16675129
MESH:D001943 Breast Neoplasms glutamyl-Se-methylselenocysteine 2.8111306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8116443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002056 Burns Ethanol 4.3516374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4810355542 16097048 16011737 15700767 16124888 15673190 16050911 16227642 16192424 15721981 3786805 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 21.7816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.783581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.783084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 21.7818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 21.7818978308 19171122 16540662 18494052 20007298 18210153 18785209 16328049 19519916 18665156 16779866 20432363 20084675 16935385 19394651 19052882 3581430 20514400 19822196 17978847 21159647 18971187 20935162 18691550 19701751 20727157 18393292 16569478 11831363 3084413 17428255 17055752 19539802 18788625 19335982 19919837 16698587 17173139 20524982 16288022 16830150 17761372 16807293 16878318 19107877 19208518 16681979 18506893 17162532 19383236 10737359 20214788 10672840 17138121 18056438 19418558 20101231 16502159 20512989
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 21.7815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 21.7816924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 21.7815289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 21.7817306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 21.781917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.537296757
MESH:D002294 Carcinoma, Squamous Cell Glutathione 7.1217015178
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.1216096774 16051514
MESH:D006332 Cardiomegaly Ethanol 6.2719332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2718670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 6.6210977129
MESH:D002386 Cataract Tretinoin 6.6217460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.287505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.2817174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.2818566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.2820056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2816129372
MESH:D002637 Chest Pain Theophylline 5.5615238202
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.4619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4616835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.8812912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 12.267624871 15500046 19486331 12927374 16629650 15913567 18590720 18164287
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.269022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.2617681005 16105132 15861022 17333356 17110522 16919318 11677210
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.5419407337 10220858
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002971 Cleft Lip Ethanol 3.4215513904
MESH:D002972 Cleft Palate Ethanol 9.0715513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.0715340226 12621046 8697196 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 9.079407595
MESH:D003092 Colitis Tretinoin 3.4017035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 6.9410194807 11198716 11873399 15451039 15513904 19302082 15451040
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 6.9415736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.949211117 14991402 9142499 9125849 8800419 9664655 9224671 17551590 16925845 10589399
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.9417688650 8888407 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2612952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7118551238
MESH:D003550 Cystic Fibrosis Glutathione 4.2219747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.512524372 12868966 8970840 14531868 11298694 18759878 11906362 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.212952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1519279558
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 35.1617522070 7624871 18289764 20133375
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 35.1621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 35.169328219 18289764 11289319 1440618 18648102 16192314 6482804 18692083 9022650 7440962 9653073 8291058 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 35.1610663392 19923254 14725611 16393943 11461765 15968718 14550746 11421492 18713872 11834606 19416960 12594235 11743745 2444490 12540782 16485898 19420014 19739265 12392966 16109766 12705907 17522070 11739529 16177239 18071297 16227642 12153990 14986274 11529661 17906064 16781746 19370779 10774834 19085960 15619225 19164858 11287661 17562736 12958197 10915739 16081117
MESH:D056486 Drug-Induced Liver Injury bromobenzene 35.1612628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 35.162869522 16177239 17522070 6623471 7179309 10092053 4309450 7120509 9327722 15968718 21278145 11566570 16227642 19336974 10915739 15998439 6884620 15027814 19085960 3786805 7440962 3732212
MESH:D056486 Drug-Induced Liver Injury Chloroform 35.163104120 3732212 6884620 7440962 17522070 6623471 2862719 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 35.1619107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 35.1611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 35.1620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 35.1617522070
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 35.1619641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D004421 Dystonia Valproic Acid 3.761851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9012538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.3115700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 11.3111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 11.3116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.769294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.8517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.603922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7820417680 18234410
MESH:D004832 Epilepsy, Absence Naloxone 8.636254150
MESH:D004832 Epilepsy, Absence Valproic Acid 8.636254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.753659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.353581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.3516704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.089664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.1217595544 16045604 16239168 12795759 19224547 12631006 61145 15959796
MESH:D005234 Fatty Liver Diethylnitrosamine 27.1220387270 21071580
MESH:D005234 Fatty Liver Ethanol 27.1218620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.1215345470
MESH:D005234 Fatty Liver Tetracycline 27.1219224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 27.1214986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3517920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4715751030 16611131 16002989 16534752 16513791
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9915451040 15513904 10194807 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.8418558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.706705139
MESH:D005355 Fibrosis Carbon Tetrachloride 13.0018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0020067830
MESH:D005355 Fibrosis Tretinoin 13.0017994277
MESH:D005756 Gastritis Acetaminophen 10.0716983495
MESH:D005756 Gastritis Ethanol 10.0715046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.7816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.7816452187
MESH:D005909 Glioblastoma Tretinoin 2.8117312396
MESH:D005911 Gliosis Paraquat 4.8511124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.757505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.999664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 14.0818590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 14.086705139
MESH:D006505 Hepatitis Carbon Tetrachloride 14.0819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5912621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4317440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.9012676792
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7316354765 16959395 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 11.6716870215
MESH:D006930 Hyperalgesia Ethanol 11.6718783367
MESH:D006930 Hyperalgesia Tretinoin 11.6716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2216899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.8215034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.8212960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7815338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3216612254
MESH:D007021 Hypospadias Diethylstilbestrol 10.2316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.2316945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.0615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.4317937319
MESH:D007248 Infertility, Male Paraquat 14.434850670
MESH:D007248 Infertility, Male sodium arsenite 14.4312646999 15346721
MESH:D007248 Infertility, Male Theophylline 14.4316988215
MESH:D007249 Inflammation Diethylnitrosamine 4.3618785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.3612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.7716393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.7019381132
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.708074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 15.5815513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.5816580747
MESH:D007569 Jaw Abnormalities Tretinoin 15.5817551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 8.9915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 8.9915618244
MESH:D007674 Kidney Diseases sodium arsenite 8.9920008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.7216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 15.726582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 15.7215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 15.7215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 8.7817184923
MESH:D007859 Learning Disorders Ethanol 8.7815451040
MESH:D007938 Leukemia Tretinoin 2.6217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6819850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6817596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9519225113 17368321 16891316 15748426 17217047 19642359 16140955 17107899 17301526 16331271 16935935 9834237 17506722 16788101 17294898 19035177 19029980 19075265 16823087 16766008 17649720 17712046 17361223 17339181 12679006
MESH:D017880 Limb Deformities, Congenital Ethanol 7.5817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.589224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.0816943688 17174718 11903743 16221502 11408273 16239168 17334410 17157831 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.0818665156 19638242 18522880 18407596 20032147
MESH:D008103 Liver Cirrhosis Ethanol 10.0815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7818295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.2817557913 18472332 16248980 17976157 18376398 12958196 12445421 16116963 18279442 15057751 17869086 18263696 17525996 12609069 18418968 12586293 16136751 15893842 15730626 15123356 12898905 16097048 13678700 14716833 18210741 17944888 18054572 12741479 10355542 18166357 18395914 14724832 17805973 18481824 18472094 15650968 17922224 15996030 17714472 14748882 15673190 14716496 18412020 18705752 18205269 15959796 15370692 17631135 14512876 20821823 15876570 17900296 12546737 18420326 12389079 15052691 18156304 16033810 18251166 18187930 17698563 17823541 12445418 17766677 16638106 12666154 15925388 16011737 18006644 18339082 17708605 18277467 12649538 18395095 14620537 18317297 17721639 12632512 18429990 11481614 17761835 16192424 17640975 17565644 15818738 15362042 15338365 12632514 12667390 16015684 16027843 15931870 17481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.2814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.2818166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.2818397230 16248980
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 8.6917184895
MESH:D008107 Liver Diseases Acetaminophen 8.6912969438 16610002 16611625 19014921 19784758 12587719 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6915830285 16964402 17285989 15720792 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6917034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3517207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.3919294768
MESH:D008113 Liver Neoplasms Clofibric Acid 16.3917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.3920101389 21167192 19638242 19690152 18754104 21047994 20501860 20492335 18977376 2862719 15885732 16942905 18978307 20583210 12112319 19073162 18644402 19833225 19812893 19255062 19294768 19642983 19551842 20405173 19850985 10737359 20137499 19427195 12771043 9163691 19254457 21071580 20452335 19256749 15175105 19996281 19090486 19426721 18648771 20118626 20434301 2422723 21278145 19499222
MESH:D008113 Liver Neoplasms Diethylstilbestrol 16.3916712894 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 16.3915276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.503712494 6587162 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.5012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.5019126423 19004024 18282651 21159647 18308698 19539802 16842330 16267830 18164116 19009564 17942915 2563599 3124819 18544905 18093689 18775883 9362446 18079962 19519916 17174075 18253720 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.5012151625
MESH:D008133 Long QT Syndrome Quinidine 4.7015350150 11989578
MESH:D008171 Lung Diseases sodium arsenite 2.9719095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9517228818
MESH:D008175 Lung Neoplasms therapeutic 10822126
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.1720970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 3.1716712894 15276417 19931552 17077188 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.1711884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2515700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2016002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.3717203775 16891317 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma Reactive Oxygen Species 4.9217992120
MESH:D008545 Melanoma sodium arsenite 4.9219082730 16487513
MESH:D008545 Melanoma Tretinoin 4.9216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008569 Memory Disorders Ethanol 3.8915451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D008881 Migraine Disorders Valproic Acid 2.9718803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.758888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.8017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0516810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.273581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.273581430 9029167
MESH:D009369 Neoplasms Diethylstilbestrol 7.4415313581
MESH:D009369 Neoplasms sodium arsenite 7.4411559025
MESH:D009369 Neoplasms Tretinoin 7.4416594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.479884423
MESH:D009410 Nerve Degeneration Paraquat 3.4816893418
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.0111399458
MESH:D009421 Nervous System Malformations Estradiol 21.0116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.0114600291
MESH:D009421 Nervous System Malformations Tretinoin 21.019125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 15.676679447
MESH:D009436 Neural Tube Defects sodium arsenite 15.6712854658
MESH:D009436 Neural Tube Defects Tretinoin 15.679142499
MESH:D009436 Neural Tube Defects Valproic Acid 15.6716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9912819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.994026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.703988306
MESH:D010051 Ovarian Neoplasms Estradiol 7.2719401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.2715276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 7.2716936753
MESH:D010146 Pain Acetaminophen 5.7716870215
MESH:D010146 Pain Tretinoin 5.7716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.4516540662
MESH:D010190 Pancreatic Neoplasms Ethanol 11.4512384795
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 11.4515580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.4515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.187296757
MESH:D010300 Parkinson Disease Paraquat 2.7016510128 11124998 11445065 12911755 16140633 15824117 15451049 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1316190885
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.7320133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.7312520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.1211026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.156228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3716977796 15687265
MESH:D011014 Pneumonia Paraquat 4.1412504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.292563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.4617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.4611222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.4620603192
MESH:D017096 Prion Diseases Tetracycline 5.1010903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.7015846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.7016740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7016039940
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.9916919318 15861022
MESH:D011537 Pruritus Naloxone 8.9915861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.2312752131 11422049
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.9018983928
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7916324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6211700416
MESH:D012135 Respiratory Sounds Paraquat 3.7511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.153692021
MESH:D012162 Retinal Degeneration Paraquat 8.1516458197
MESH:D012208 Rhabdomyosarcoma marker/mechanism 16669873
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.9116283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.9119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 8.6818551238
MESH:D012640 Seizures Ethanol 8.689754883
MESH:D012640 Seizures Valproic Acid 8.6814763951 15475178 11738929 1511512 16876388 11044598 17978042 3137016
MESH:D012878 Skin Neoplasms sodium arsenite 12.3318572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.338532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.3316192470
MESH:D012878 Skin Neoplasms Tretinoin 12.3316467112
MESH:D013088 Spermatocele Diethylstilbestrol 10.6616709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 8.7612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2312833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2518456281
MESH:D013274 Stomach Neoplasms Ethanol 3.2518456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.2517261132
MESH:D013276 Stomach Ulcer Ethanol 3.2616755016 17189318 9211565 9562338 17918041 11906479
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.999754883
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.4920133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.266587162 6582329 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.267505956
MESH:D013964 Thyroid Neoplasms N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 15.2616940797
MESH:D013964 Thyroid Neoplasms Tretinoin 15.2616026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5216051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.9217262798
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.213119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.9016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.908074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.9017306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.9017306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.348888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0010091137
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.3316175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.3311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.3316129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.4915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2916752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1316002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.1117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33966
    • No data
    Releated disease ID Related disease Name
    PA444119Eye Diseases
    PA446225Eye Diseases, Hereditary
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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