AutismKB 2.0

Annotation Detail for EP400


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Basic Information Top
Gene Symbol:EP400 ( CAGH32,DKFZP434I225,FLJ42018,FLJ45115,P400,TNRC12 )
Gene Full Name: E1A binding protein p400
Band: 12q24.33
Quick LinksEntrez ID:57634; OMIM: 606265; Uniprot ID:EP400_HUMAN; ENSEMBL ID: ENSG00000183495; HGNC ID: 11958
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00057Wnt signaling pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
2118Adenovirus infection
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EP400 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of EP400 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of EP400 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of EP400 mRNAincreases expression 20504355
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EP400 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EP400 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of EP400 mRNA]affects reaction|decreases expression 15016801
D013629 Tamoxifen Tamoxifen results in decreased expression of EP400 mRNAdecreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EP400 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.637525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6314514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3520464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3514692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.3517638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Fluorouracil 9.4515504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.4511748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.9616595493 16557594 19217205 18357371 15136595 18608205 16110121
MESH:D001943 Breast Neoplasms Tamoxifen 1.9620005174 15668708 21138602 20135344 20065188 16202921 19244106 19084267 16873071 18629630 18351453 19155303 16273361 19142967 20859285 20544844 18821012 19011961 16818667 11161223 19289846 15565566 19487384 19200415 17049068 21152245 19410462 18815881 19066611 19189210 18425577 19189212 18855134 17893378 18984771 20390343 19288272 19115204 19103187 19221464 17440819 17261762 17242785 18997820 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 8.8317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.833084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8316332177 16799960 17045692 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8316924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1118695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8420419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8416757204 18986760 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8514694615
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517681005 15861022 16105132 17110522 16919318 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2616510598 16340194 17725105 15001691 17018589 18772588 17016597 17169374 17287894 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015148649 16524972 15289873 18448328 18383874 20501625 17594712 17255274 17454858 18288408 17016601 14970324 18509181 16391804 17695437 18949393 16331619 17094418 16282729 18802399 17401013 16303861
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.9115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.9114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.4921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4912705907 18071297 11287661 11461765 10915739 11834606 10663392 16227642 11529661 19739265 17906064 15968718 11739529 19085960 19420014 16081117 18713872 14986274 15619225 16109766 19164858 12958197 16393943 14725611 19370779 16781746 12153990 19416960 12594235 17522070 16485898 11421492 16177239 10774834 12392966 14550746 19923254 2444490 11743745 12540782 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1917893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6615173087 16481741 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005234 Fatty Liver Tamoxifen 8.5119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5415102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8211294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 16354765 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tamoxifen 5.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.6616705839
MESH:D007680 Kidney Neoplasms Fluorouracil 13.6616985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.6618625569
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 16611625 12969438 16610002 19460945 12587719 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.097678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.0921137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 15.0916603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Tamoxifen 15.0916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.202876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0217053015 18569708 18520028 18816296 20464547 6695378 20135361 20869020 20064080
MESH:D008175 Lung Neoplasms Fluorouracil 5.0215246190
MESH:D008175 Lung Neoplasms Tamoxifen 5.0218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7614580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.1516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.1516757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4211141357
MESH:D009369 Neoplasms Fluorouracil 5.4218600527 18239605 16928823
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9016049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.9014694615
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7316500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5017292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5018626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2316160472 18286688 15538739 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.472093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4717522103 17498489 18396642 17172411 19084572 18567086 15786421 16951190 16424979 19015929
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7516049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7517053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7516712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018