Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of EP400 mRNA | affects expression | 21346803
|
C035207 |
4-amino-2,6-dinitrotoluene |
4-amino-2,6-dinitrotoluene affects the expression of EP400 mRNA | affects expression | 21346803
|
D000082 |
Acetaminophen |
Acetaminophen affects the expression of EP400 mRNA | affects expression | 17562736
|
D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in increased expression of EP400 mRNA | increases expression | 20504355
|
D004997 |
Ethinyl Estradiol |
Ethinyl Estradiol results in increased expression of EP400 mRNA | increases expression | 17942748
|
D004997 |
Ethinyl Estradiol |
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EP400 mRNA | affects cotreatment|increases expression | 17942748
|
D005472 |
Fluorouracil |
TP53 protein affects the reaction [Fluorouracil results in decreased expression of EP400 mRNA] | affects reaction|decreases expression | 15016801
|
D013629 |
Tamoxifen |
Tamoxifen results in decreased expression of EP400 mRNA | decreases expression | 17555576
|
D013749 |
Tetrachlorodibenzodioxin |
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EP400 mRNA | affects cotreatment|increases expression | 17942748
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000008 |
Abdominal Neoplasms |
|
Tamoxifen |
4.92 | 14745880 |
MESH:D000014 |
Abnormalities, Drug-Induced |
|
4-amino-2,6-dinitrotoluene |
9.63 | 7525203 |
MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
9.63 | 14514962 11752688 15322242 |
MESH:D000152 |
Acne Vulgaris |
|
Ethinyl Estradiol |
4.32 | 17505938 |
MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
7.35 | 20464547 20127859 |
MESH:D000230 |
Adenocarcinoma |
|
Ethinyl Estradiol |
7.35 | 14692618 |
MESH:D000230 |
Adenocarcinoma |
|
Fluorouracil |
7.35 | 17638652 |
MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.78 | 6695378 |
MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
3.71 | 16835633 |
MESH:D000740 |
Anemia |
|
Fluorouracil |
9.45 | 15504547 16511603 17963324 |
MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
9.45 | 11748828 |
MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.22 | 10982225 |
MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.38 | 19183758 |
MESH:D001161 |
Arteriosclerosis |
|
Ethinyl Estradiol |
3.77 | 11256880 |
MESH:D001169 |
Arthritis, Experimental |
|
Ethinyl Estradiol |
2.80 | 15885639 |
MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
3.29 | 12125929 |
MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.17 | 15340226 |
MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
2.91 | 15746008 |
MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.96 | 20146248 17474063 |
MESH:D001943 |
Breast Neoplasms |
|
Fluorouracil |
1.96 | 16595493 16557594 19217205 18357371 15136595 18608205 16110121 |
MESH:D001943 |
Breast Neoplasms |
|
Tamoxifen |
1.96 | 20005174 15668708 21138602 20135344 20065188 16202921 19244106 19084267 16873071 18629630 18351453 19155303 16273361 19142967 20859285 20544844 18821012 19011961 16818667 11161223 19289846 15565566 19487384 19200415 17049068 21152245 19410462 18815881 19066611 19189210 18425577 19189212 18855134 17893378 18984771 20390343 19288272 19115204 19103187 19221464 17440819 17261762 17242785 18997820 19059307 |
MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
1.96 | 20435547 |
MESH:D002276 |
Carcinoid Tumor |
|
Fluorouracil |
5.04 | 16051944 |
MESH:D002277 |
Carcinoma |
|
Fluorouracil |
8.83 | 17121937 |
MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
8.83 | 16835633 |
MESH:D018270 |
Carcinoma, Ductal, Breast |
|
Tamoxifen |
4.81 | 19066611 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
6.83 | 16705839 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
6.83 | 3084413 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Fluorouracil |
6.83 | 16332177 16799960 17045692 17971768 17088986 18930000 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Tamoxifen |
6.83 | 16924424 |
MESH:D002292 |
Carcinoma, Renal Cell |
|
Fluorouracil |
3.11 | 18695887 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
4.84 | 20419170 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Fluorouracil |
4.84 | 16757204 18986760 17066447 16280240 |
MESH:D002295 |
Carcinoma, Transitional Cell |
|
Tamoxifen |
3.84 | 17572228 |
MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
2.49 | 16120746 18670907 18850075 |
MESH:D002386 |
Cataract |
|
4-amino-2,6-dinitrotoluene |
7.85 | 14694615 |
MESH:D002386 |
Cataract |
|
Acetaminophen |
7.85 | 10977129 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
2.93 | 6135515 |
MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
3.38 | 16835633 |
MESH:D002779 |
Cholestasis |
|
Ethinyl Estradiol |
3.05 | 17681005 15861022 16105132 17110522 16919318 17333356 11677210 |
MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.19 | 15668235 15340226 12621046 8697196 16354765 |
MESH:D003110 |
Colonic Neoplasms |
|
Fluorouracil |
2.26 | 16510598 16340194 17725105 15001691 17018589 18772588 17016597 17169374 17287894 17172411 |
MESH:D015179 |
Colorectal Neoplasms |
|
Fluorouracil |
2.00 | 15148649 16524972 15289873 18448328 18383874 20501625 17594712 17255274 17454858 18288408 17016601 14970324 18509181 16391804 17695437 18949393 16331619 17094418 16282729 18802399 17401013 16303861 |
MESH:D000013 |
Congenital Abnormalities |
|
4-amino-2,6-dinitrotoluene |
9.91 | 15095906 |
MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
9.91 | 14669216 17141729 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.26 | 10048152 15322242 20055451 |
MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.32 | 18551238 |
MESH:D007644 |
Darier Disease |
|
Fluorouracil |
5.13 | 16733453 |
MESH:D003711 |
Demyelinating Diseases |
|
Tamoxifen |
4.67 | 19031437 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
1.71 | 17107852 |
MESH:D003928 |
Diabetic Nephropathies |
|
Tamoxifen |
3.69 | 19279558 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
9.49 | 18551238 21346803 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
4-amino-2,6-dinitrotoluene |
9.49 | 21346803 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
9.49 | 12705907 18071297 11287661 11461765 10915739 11834606 10663392 16227642 11529661 19739265 17906064 15968718 11739529 19085960 19420014 16081117 18713872 14986274 15619225 16109766 19164858 12958197 16393943 14725611 19370779 16781746 12153990 19416960 12594235 17522070 16485898 11421492 16177239 10774834 12392966 14550746 19923254 2444490 11743745 12540782 17562736 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
9.49 | 20420201 |
MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.47 | 19426721 |
MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
2.93 | 11462148 |
MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
2.61 | 11000095 12711302 |
MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.28 | 15322242 18230668 16714409 |
MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Ethinyl Estradiol |
9.90 | 12538720 |
MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Tamoxifen |
9.90 | 19031437 |
MESH:D016889 |
Endometrial Neoplasms |
|
Tamoxifen |
3.19 | 17893378 16202921 19155303 20544844 |
MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.25 | 9294722 10568697 |
MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.66 | 16530937 |
MESH:D004938 |
Esophageal Neoplasms |
|
Fluorouracil |
4.66 | 15173087 16481741 16337965 17638652 16785472 |
MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.19 | 11564622 |
MESH:D005234 |
Fatty Liver |
|
Ethinyl Estradiol |
8.51 | 15345470 |
MESH:D005234 |
Fatty Liver |
|
Tamoxifen |
8.51 | 19224547 14986274 |
MESH:D052776 |
Female Urogenital Diseases |
|
Tamoxifen |
3.37 | 16709447 |
MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
3.76 | 11858732 |
MESH:D018221 |
Fibromatosis, Abdominal |
|
Tamoxifen |
4.87 | 14745880 |
MESH:D018222 |
Fibromatosis, Aggressive |
|
Tamoxifen |
4.52 | 19069698 |
MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
3.25 | 20067830 |
MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.05 | 16983495 |
MESH:D005910 |
Glioma |
|
Fluorouracil |
2.95 | 16145905 |
MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
4.97 | 10696789 |
MESH:D006258 |
Head and Neck Neoplasms |
|
Fluorouracil |
3.54 | 15102660 15162350 18337622 |
MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
6.82 | 20471113 |
MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
6.82 | 11294989 10048152 |
MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.58 | 11000095 |
MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
3.20 | 15340226 16120746 12621046 |
MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
4.42 | 15340226 16354765 18606429 16959395 8697196 |
MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.89 | 16870215 |
MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
1.98 | 18850075 18670907 |
MESH:D007021 |
Hypospadias |
|
Ethinyl Estradiol |
4.12 | 16945680 16569931 |
MESH:D007247 |
Infertility, Female |
|
Ethinyl Estradiol |
3.72 | 12013081 |
MESH:D007248 |
Infertility, Male |
|
Ethinyl Estradiol |
2.64 | 17937319 |
MESH:D007249 |
Inflammation |
|
Tamoxifen |
5.26 | 19457130 |
MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
5.26 | 12200463 12878042 |
MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.58 | 16580747 |
MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.32 | 15629191 12587719 |
MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
13.66 | 16705839 |
MESH:D007680 |
Kidney Neoplasms |
|
Fluorouracil |
13.66 | 16985049 |
MESH:D007680 |
Kidney Neoplasms |
|
Tamoxifen |
13.66 | 18625569 |
MESH:D008064 |
Lipidoses |
|
Tamoxifen |
3.32 | 15342952 17567588 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tamoxifen |
2.34 | 18564211 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
2.34 | 12878042 |
MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.67 | 19014921 16611625 12969438 16610002 19460945 12587719 19784758 11587558 |
MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.46 | 17185352 16871587 |
MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
15.09 | 7678174 |
MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
15.09 | 21137059 20195826 |
MESH:D008113 |
Liver Neoplasms |
|
Fluorouracil |
15.09 | 16603448 17045692 18383874 15113037 |
MESH:D008113 |
Liver Neoplasms |
|
Tamoxifen |
15.09 | 16684651 |
MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
15.09 | 16984957 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
6.20 | 2876784 2876786 6135515 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
6.20 | 12151625 |
MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
5.02 | 17053015 18569708 18520028 18816296 20464547 6695378 20135361 20869020 20064080 |
MESH:D008175 |
Lung Neoplasms |
|
Fluorouracil |
5.02 | 15246190 |
MESH:D008175 |
Lung Neoplasms |
|
Tamoxifen |
5.02 | 18625569 |
MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
5.02 | 11884234 19555203 |
MESH:D008178 |
Lupus Erythematosus, Cutaneous |
|
Fluorouracil |
5.13 | 15086387 |
MESH:D015674 |
Mammary Neoplasms, Animal |
|
Tamoxifen |
4.10 | 19428831 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Tamoxifen |
2.76 | 14580682 16827153 11731420 19196723 19196722 |
MESH:D020149 |
Manganese Poisoning |
|
Tamoxifen |
4.92 | 19453300 |
MESH:D008545 |
Melanoma |
|
Tamoxifen |
1.91 | 12393984 19393235 |
MESH:D018328 |
Melanoma, Amelanotic |
|
Tamoxifen |
4.52 | 15990972 |
MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
3.87 | 19513568 |
MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
9.15 | 16381670 |
MESH:D009062 |
Mouth Neoplasms |
|
Fluorouracil |
9.15 | 16757204 18986760 |
MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.21 | 12213967 |
MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.20 | 7678174 18551238 |
MESH:D009362 |
Neoplasm Metastasis |
|
Tamoxifen |
2.63 | 19393235 |
MESH:D009364 |
Neoplasm Recurrence, Local |
|
Tamoxifen |
2.58 | 19410462 |
MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
5.42 | 11141357 |
MESH:D009369 |
Neoplasms |
|
Fluorouracil |
5.42 | 18600527 18239605 16928823 |
MESH:D009376 |
Neoplasms, Hormone-Dependent |
|
Tamoxifen |
4.38 | 19189210 19200415 19196722 |
MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
3.49 | 14600291 |
MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.07 | 18514411 |
MESH:D020258 |
Neurotoxicity Syndromes |
|
Fluorouracil |
3.59 | 16436463 |
MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
9.90 | 16049721 |
MESH:D009784 |
Occupational Diseases |
|
4-amino-2,6-dinitrotoluene |
9.90 | 14694615 |
MESH:D010146 |
Pain |
|
Acetaminophen |
2.59 | 16870215 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Fluorouracil |
2.73 | 16500647 16929163 15113037 19003803 |
MESH:D016584 |
Panic Disorder |
|
Ethinyl Estradiol |
3.95 | 11578682 |
MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
4.62 | 12520081 |
MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
3.84 | 18163543 |
MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
3.53 | 11118676 11896295 11399792 11222880 |
MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.50 | 17292933 |
MESH:D011471 |
Prostatic Neoplasms |
|
Fluorouracil |
2.50 | 18626508 19082440 |
MESH:D011471 |
Prostatic Neoplasms |
|
Tamoxifen |
2.50 | 15067354 |
MESH:D011537 |
Pruritus |
|
Ethinyl Estradiol |
3.65 | 15861022 16919318 |
MESH:D012004 |
Rectal Neoplasms |
|
Fluorouracil |
4.23 | 16160472 18286688 15538739 18722050 |
MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.12 | 18990726 |
MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.69 | 18551238 |
MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
5.80 | 10029692 19755658 |
MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
5.80 | 16192470 |
MESH:D013088 |
Spermatocele |
|
Ethinyl Estradiol |
12.85 | 16709447 |
MESH:D013088 |
Spermatocele |
|
Tamoxifen |
12.85 | 16709447 |
MESH:D013119 |
Spinal Cord Injuries |
|
Tamoxifen |
4.38 | 19457130 |
MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
2.47 | 2093021 20155912 |
MESH:D013274 |
Stomach Neoplasms |
|
Fluorouracil |
2.47 | 17522103 17498489 18396642 17172411 19084572 18567086 15786421 16951190 16424979 19015929 |
MESH:D019851 |
Thrombophilia |
|
Ethinyl Estradiol |
3.88 | 11994571 |
MESH:D013927 |
Thrombosis |
|
Ethinyl Estradiol |
3.37 | 15669648 |
MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.28 | 12697716 |
MESH:D014062 |
Tongue Neoplasms |
|
Fluorouracil |
4.22 | 16280240 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
8.75 | 16049721 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
8.75 | 17053015 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Tamoxifen |
8.75 | 16712894 17572228 8653321 |
MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.66 | 10091137 |
MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.24 | 10982225 |
MESH:D002583 |
Uterine Cervical Neoplasms |
|
Fluorouracil |
4.11 | 16803524 |
MESH:D014594 |
Uterine Neoplasms |
|
Ethinyl Estradiol |
3.58 | 14692618 |
MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
4.97 | 12125929 |
MESH:D020246 |
Venous Thrombosis |
|
Ethinyl Estradiol |
3.78 | 15869587 14671159 |
MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
4.62 | 15886252 |