AutismKB 2.0

Annotation Detail for ARHGAP23


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Basic Information Top
Gene Symbol:ARHGAP23 ( KIAA1501 )
Gene Full Name: Rho GTPase activating protein 23
Band: 17q12
Quick LinksEntrez ID:57636; OMIM: 610590; Uniprot ID:RHG23_HUMAN; ENSEMBL ID: ENSG00000225485; HGNC ID: 29293
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ARHGAP23 mRNAincreases expression 16788091
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARHGAP23 mRNAdecreases expression 19150397
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ARHGAP23 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARHGAP23 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ARHGAP23 mRNAincreases expression 18301758
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ARHGAP23 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9816609825 18558336 18775368 19460635 18177632 18985861 17688650 15238991 17157402 19232924 18316065 17507914 18940202 20603192 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2519641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.643659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.5316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.917562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver pirinixic acid 8.9919236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.9919224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 18467677 19772884 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1116612254
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9215890375 16377806 20007298
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.348888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9616876388 15475178 3137016 17978042 11044598 11738929 14763951 1511512
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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