AutismKB 2.0

Annotation Detail for PHRF1


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Basic Information Top
Gene Symbol:PHRF1 ( KIAA1542,RNF221 )
Gene Full Name: PHD and ring finger domains 1
Band: 11p15.5
Quick LinksEntrez ID:57661; OMIM: 611780; Uniprot ID:PHRF1_HUMAN; ENSEMBL ID: ENSG00000070047; HGNC ID: 24351
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2146Lupus erythematosus
Desease Name
systemic lupus erythematosus
IMMUNE
Desease Name
Systemic lupus erythematosus
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PHRF1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PHRF1 mRNAaffects expression 16483693
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.4418287403
MESH:D000799 Angioedema Acetaminophen 4.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8310977129
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6810915739 19739265 11421492 18713872 17522070 12153990 15968718 10663392 19416960 19923254 16227642 11743745 11834606 14550746 11461765 12594235 18071297 19420014 17906064 15619225 10774834 14725611 16177239 2444490 19085960 12392966 16081117 11739529 12705907 12540782 17562736 16393943 19370779 19164858 16485898 11529661 16109766 16781746 12958197 11287661 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.1719426721
MESH:D005756 Gastritis Acetaminophen 4.7416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.1116870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4415629191 12587719
MESH:D008107 Liver Diseases Acetaminophen 1.7119784758 12587719 19014921 19460945 12969438 11587558 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.7417185352 16871587
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 18204446
MESH:D008546 Melanoma, Experimental Acetaminophen 4.3319513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3118514411
MESH:D010146 Pain Acetaminophen 2.8216870215
MESH:D014581 Urticaria Acetaminophen 3.5810982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164724459
  • No data
    Releated disease ID Related disease Name
    PA444819Lupus erythematosus
    PA444822Lupus Erythematosus, Systemic
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018