Annotation Detail for PLEKHA4
Basic Information
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| Gene Symbol: | PLEKHA4 ( PEPP1 ) |
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| Gene Full Name: | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
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| Band: | 19q13.33 |
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| Quick Links | Entrez ID:57664; OMIM: 607769; Uniprot ID:PKHA4_HUMAN; ENSEMBL ID: ENSG00000105559; HGNC ID: 14339 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of PLEKHA4 mRNA | affects expression | 21346803
|
| D019324 |
beta-Naphthoflavone |
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLEKHA4 mRNA | affects cotreatment|increases expression | 18164116
|
| D004041 |
Dietary Fats |
Dietary Fats results in increased expression of PLEKHA4 mRNA | increases expression | 18042831
|
| D004052 |
Diethylnitrosamine |
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLEKHA4 mRNA | affects cotreatment|increases expression | 18164116
|
| C041786 |
palm oil |
palm oil results in increased expression of PLEKHA4 mRNA | increases expression | 18042831
|
| D018038 |
Sodium Selenite |
Sodium Selenite results in decreased expression of PLEKHA4 mRNA | decreases expression | 18175754
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000236 |
Adenoma |
|
beta-Naphthoflavone |
7.44 | 19389873 |
| MESH:D000236 |
Adenoma |
|
Diethylnitrosamine |
7.44 | 6695378 10737359 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
Diethylnitrosamine |
4.36 | 19061943 18056438 16434500 17162532 19052882 17620307 |
| MESH:D001161 |
Arteriosclerosis |
|
Dietary Fats |
4.31 | 15238619 |
| MESH:D001943 |
Breast Neoplasms |
|
Dietary Fats |
2.15 | 20435547 |
| MESH:D001943 |
Breast Neoplasms |
|
Diethylnitrosamine |
2.15 | 17474063 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
3.11 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Diethylnitrosamine |
3.11 | 20214788 19539802 20101231 18785209 16540662 17978847 16935385 20084675 16830150 17428255 16698587 18393292 18494052 16328049 19208518 18506893 10737359 20727157 18691550 3084413 19822196 19919837 16779866 16502159 19418558 19701751 19383236 18788625 20512989 19394651 21159647 19519916 20432363 19052882 18971187 18210153 20524982 16878318 18056438 19335982 17162532 20514400 18665156 16807293 11831363 20935162 16681979 16288022 20007298 17173139 10672840 17761372 18978308 19171122 17055752 17138121 19107877 3581430 16569478 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Diethylnitrosamine |
3.06 | 2727394 7505956 21159647 17174075 |
| MESH:D018281 |
Cholangiocarcinoma |
|
Diethylnitrosamine |
3.97 | 19052882 |
| MESH:D019457 |
Chromosome Breakage |
|
Sodium Selenite |
5.17 | 15894690 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
4.43 | 18551238 |
| MESH:D003920 |
Diabetes Mellitus |
|
Sodium Selenite |
4.06 | 16285004 |
| MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Diethylnitrosamine |
2.25 | 20387270 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
6.73 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Diethylnitrosamine |
6.73 | 19107877 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Sodium Selenite |
6.73 | 15131321 |
| MESH:D050171 |
Dyslipidemias |
|
Dietary Fats |
3.67 | 18367378 |
| MESH:D004931 |
Esophageal Achalasia |
|
Diethylnitrosamine |
5.64 | 16302075 |
| MESH:D005234 |
Fatty Liver |
|
Dietary Fats |
8.96 | 17967931 19004024 19551842 18296743 |
| MESH:D005234 |
Fatty Liver |
|
Diethylnitrosamine |
8.96 | 20387270 21071580 |
| MESH:D005355 |
Fibrosis |
|
Dietary Fats |
3.94 | 18296743 |
| MESH:D006937 |
Hypercholesterolemia |
|
Dietary Fats |
3.92 | 21332399 |
| MESH:D006949 |
Hyperlipidemias |
|
Dietary Fats |
3.97 | 21332399 |
| MESH:D007249 |
Inflammation |
|
Dietary Fats |
5.59 | 20412841 |
| MESH:D007249 |
Inflammation |
|
Diethylnitrosamine |
5.59 | 18785209 |
| MESH:D007333 |
Insulin Resistance |
|
Dietary Fats |
8.13 | 11836018 18457598 |
| MESH:D007333 |
Insulin Resistance |
|
Sodium Selenite |
8.13 | 14714311 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
3.24 | 16705839 |
| MESH:D008103 |
Liver Cirrhosis |
|
Dietary Fats |
7.15 | 18296743 |
| MESH:D008103 |
Liver Cirrhosis |
|
Diethylnitrosamine |
7.15 | 18407596 18522880 19638242 18665156 20032147 |
| MESH:D008107 |
Liver Diseases |
|
Diethylnitrosamine |
2.16 | 17034775 |
| MESH:D008113 |
Liver Neoplasms |
|
beta-Naphthoflavone |
5.10 | 21295105 19389873 |
| MESH:D008113 |
Liver Neoplasms |
|
Diethylnitrosamine |
5.10 | 12112319 20434301 19294768 19996281 21047994 18648771 9163691 19427195 20452335 16942905 21278145 18977376 19426721 19551842 19499222 20118626 20405173 19642983 19256749 15175105 20492335 20501860 19638242 19090486 19812893 15885732 10737359 20583210 12771043 21167192 20137499 19255062 18754104 2862719 19833225 18978307 18644402 19073162 19690152 2422723 19850985 21071580 19254457 20101389 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
beta-Naphthoflavone |
6.75 | 18164116 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Diethylnitrosamine |
6.75 | 17854601 16267830 9362446 19009564 18282651 19539802 17174075 18775883 18253720 18079962 19004024 3124819 18308698 17942915 18093689 18544905 19126423 18164116 2563599 16842330 19519916 21159647 |
| MESH:D008175 |
Lung Neoplasms |
|
Diethylnitrosamine |
1.76 | 6695378 21163286 20970405 20512841 |
| MESH:D016393 |
Lymphoma, B-Cell |
|
Sodium Selenite |
4.41 | 14737004 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
4.32 | 18551238 |
| MESH:D009362 |
Neoplasm Metastasis |
|
Diethylnitrosamine |
2.67 | 3581430 9029167 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Diethylnitrosamine |
3.61 | 20387270 |
| MESH:D009461 |
Neurologic Manifestations |
|
Diethylnitrosamine |
5.64 | 20387270 |
| MESH:D009765 |
Obesity |
|
Dietary Fats |
2.34 | 18457598 18674790 20518802 19632207 11836018 17217161 20132043 21332399 16723640 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
3.73 | 16049721 12819281 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
Diethylnitrosamine |
2.51 | 16540662 |
| MESH:D011230 |
Precancerous Conditions |
|
Diethylnitrosamine |
3.84 | 2563599 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Sodium Selenite |
3.34 | 18760546 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
2.73 | 18551238 |
| MESH:D013274 |
Stomach Neoplasms |
|
Diethylnitrosamine |
1.76 | 18456281 |
| MESH:D013964 |
Thyroid Neoplasms |
|
Diethylnitrosamine |
3.22 | 7505956 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
2.38 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
4.78 | 10091137 |
| MESH:D015430 |
Weight Gain |
|
Dietary Fats |
4.02 | 16723640 |
| Drugbank ID |
Action |
Drug Name |
Description |
|---|
| DB01863 |
- |
Inositol 1,3,4,5-Tetrakisphosphate |
|
Related Pathway Information