AutismKB 2.0

Annotation Detail for RNF213


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Basic Information Top
Gene Symbol:RNF213 ( C17orf27,DKFZp762N1115,FLJ13051,KIAA1554,KIAA1618,MGC46622,MGC9929,NET57 )
Gene Full Name: ring finger protein 213
Band: 17q25.3
Quick LinksEntrez ID:57674; OMIM: NA; Uniprot ID:ALO17_HUMAN; ENSEMBL ID: ENSG00000173821,ENSG00000180843; HGNC ID: 14539
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of RNF213 mRNAdecreases expression 18687144
D004041 Dietary Fats Dietary Fats results in increased expression of RNF213 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of RNF213 mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RNF213 mRNAdecreases expression 20055451
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RNF213 mRNAincreases expression 17101203
D014635 Valproic Acid Valproic Acid results in increased expression of RNF213 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of RNF213 mRNAaffects expression 19015723
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of RNF213 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6615322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.668875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.189612607
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001008 Anxiety Disorders Valproic Acid 9.6117497229
MESH:D001008 Anxiety Disorders vinclozolin 9.6119015723
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9919460635 18558336 16609825 17507914 18940202 18316065 19232924 15238991 17688650 18985861 18775368 18396377 17157402 18177632 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.578888407
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 16120746 18670907
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15340226 12621046 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5417688650 16575769 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9919641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.9111462148
MESH:D004362 Drug Toxicity Zidovudine 8.9115040536
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Dietary Fats 14.9717967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Valproic Acid 14.9714986274 19224547
MESH:D005234 Fatty Liver Zidovudine 14.9718299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005355 Fibrosis Dietary Fats 9.8418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 5.0212579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 15340226 16120746
MESH:D015658 HIV Infections Zidovudine 3.6211698656 11141242 20032539 11363243 17358032
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 16959395 8697196 18606429 15340226
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Dietary Fats 5.3420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.2711836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms Zidovudine 4.0212579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.6920370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3817365036
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5919555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 2.5918800350
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2716166281 16966607 18303189
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.2817358032
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.3016359493 8888407
MESH:D009765 Obesity Dietary Fats 2.3421332399 20518802 20132043 18457598 17217161 16723640 11836018 19632207 18674790
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2510923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.6911118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 18.6920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 18.6918220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1117322281 17365031 17975199 15814490
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9111738929 11044598 17978042 1511512 14763951 3137016 16876388 15475178
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1212579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162401681
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    Releated drug ID Related drug Name
    PA451257risperidone
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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