AutismKB 2.0

Annotation Detail for ALS2


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Basic Information Top
Gene Symbol:ALS2 ( ALS2CR6,ALSJ,FLJ31851,IAHSP,KIAA1563,MGC87187,PLSJ )
Gene Full Name: amyotrophic lateral sclerosis 2 (juvenile)
Band: 2q33.1
Quick LinksEntrez ID:57679; OMIM: 606352; Uniprot ID:ALS2_HUMAN; ENSEMBL ID: ENSG00000003393; HGNC ID: 443
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05014Amyotrophic lateral sclerosis (ALS)
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00058Amyotrophic lateral sclerosis
Desease IDDesease Name
1982Myopathy
2126Encephalopathies
2134Amyotrophic lateral sclerosis
Desease Name
CHEMDEPENDENCY
smoking cessation
Infantile-onset ascending hereditary spastic paralysis
No data
Desease Name
Spastic paralysis, infantile onset ascending
Amyotrophic lateral sclerosis, juvenile
Primary lateral sclerosis, juvenile
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ALS2 mRNAincreases expression 19933214
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of ALS2 mRNAincreases expression 18687144
D002117 Calcitriol Calcitriol results in increased expression of ALS2 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALS2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALS2 mRNAaffects cotreatment|increases expression 17942748
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ALS2 mRNAincreases expression 19339665
D008070 Lipopolysaccharides methyldithiocarbamate affects the reaction [Lipopolysaccharides results in increased expression of ALS2 mRNA]affects reaction|increases expression 19339665
C008435 methyldithiocarbamate methyldithiocarbamate affects the reaction [Lipopolysaccharides results in increased expression of ALS2 mRNA]affects reaction|increases expression 19339665
C006253 pirinixic acid pirinixic acid results in decreased expression of ALS2 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of ALS2 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALS2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALS2 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.9218653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 9.9218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
OMIM:205100 AMYOTROPHIC LATERAL SCLEROSIS 2, JUVENILE marker/mechanism
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Calcitriol 2.0811237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6811237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3316919318 17681005 11677210 17333356 16105132 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 16354765 12621046 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.0515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7317637181 15328337 15821434
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3615345470
MESH:D005234 Fatty Liver pirinixic acid 8.3619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005334 Fever Lipopolysaccharides 4.249205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 8697196 18606429 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Lipopolysaccharides 5.4517237260 9205823 17963957 12878042 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4512878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5812878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008113 Liver Neoplasms pirinixic acid 4.5116377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 10.3417365036
MESH:D055370 Lung Injury Lipopolysaccharides 10.3421114838
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2618303189 16966607 16166281
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D011014 Pneumonia Lipopolysaccharides 4.8911605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11118676 11222880
OMIM:606353 PRIMARY LATERAL SCLEROSIS, JUVENILE marker/mechanism
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5016289102 18247401 16644109 15754350 12479363
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1017322281 17975199 17365031 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
OMIM:607225 SPASTIC PARALYSIS, INFANTILE-ONSET ASCENDING marker/mechanism
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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