AutismKB 2.0

Annotation Detail for CACHD1


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Basic Information Top
Gene Symbol:CACHD1 ( KIAA1573,RP4-655E10.1 )
Gene Full Name: cache domain containing 1
Band: 1p31.3
Quick LinksEntrez ID:57685; OMIM: NA; Uniprot ID:CAHD1_HUMAN; ENSEMBL ID: ENSG00000158966; HGNC ID: 29314
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CACHD1 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of CACHD1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CACHD1 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CACHD1 mRNAaffects binding|increases activity|increases expression 19710929
D013629 Tamoxifen Tamoxifen affects the expression of CACHD1 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1719011961 19200415 17893378 19066611 18815881 19059307 18351453 19155303 18855134 19289846 19221464 18997820 19189212 21152245 19189210 18821012 19142967 19103187 15565566 19244106 19115204 16273361 16202921 20005174 20544844 11161223 17440819 20859285 17049068 18984771 19084267 19288272 21138602 16818667 15668708 20065188 16873071 18629630 19410462 18425577 20390343 20135344 19487384 17261762 17242785
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2615700767 16097048 16192424 18705752 16050911 10355542 15721981 16124888 15673190 3786805 16227642 16011737
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1418788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 14.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.8917681005 11677210 16105132 17333356 16919318 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 14.8919176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1115968718 16177239 11566570 4309450 9327722 7440962 19336974 16227642 15027814 2869522 15998439 19085960 3732212 17522070 6884620 21278145 7120509 10915739 7179309 3786805 10092053 6623471
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2616202921 19155303 17893378 20544844
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.0515959796 12795759 16239168 16045604 12631006 61145 17595544 19224547
MESH:D005234 Fatty Liver Cyclosporine 29.0519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.0515345470
MESH:D005234 Fatty Liver pirinixic acid 29.0520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 29.0514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 10.3318705752
MESH:D005355 Fibrosis Cyclosporine 10.3312168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 16221962 19176532 19772884
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.528314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3318625569
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816943688 11408273 17157831 21278145 16221502 17334410 11903743 16239168 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6317714472 17640975 14512876 17805973 14748882 12898905 16033810 17631135 15931870 18156304 12389079 13678700 17761835 17766677 12666154 17525996 12649538 12632512 15370692 18418968 17481882 16192424 16015684 18187930 17976157 15876570 18251166 17557913 18376398 12445421 14620537 15338365 15818738 12546737 18263696 16248980 17698563 12632514 16011737 17708605 15925388 18210741 16136751 18412020 12609069 18395914 18006644 15730626 16097048 15673190 14716496 12667390 14716833 16116963 17900296 15057751 16638106 18705752 18277467 18429990 17922224 14724832 15052691 15996030 18472332 12958196 17823541 15650968 17869086 16027843 18472094 15893842 18054572 18205269 15959796 11481614 18420326 20821823 18395095 12741479 12445418 10355542 15362042 18339082 12586293 15123356 17721639 18481824 18166357 17565644 18279442 18317297 17944888
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6318564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516964402 16246199 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0619294768
MESH:D008113 Liver Neoplasms pirinixic acid 8.0616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 8.0616684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8112014681 15583823
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8311731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4617572228 16712894 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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