AutismKB 2.0

Annotation Detail for LRRC4C


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Basic Information Top
Gene Symbol:LRRC4C ( KIAA1580,NGL-1,NGL1 )
Gene Full Name: leucine rich repeat containing 4C
Band: 11p12
Quick LinksEntrez ID:57689; OMIM: 608817; Uniprot ID:LRC4C_HUMAN; ENSEMBL ID: ENSG00000148948; HGNC ID: 29317
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LRRC4C mRNAaffects expression 17484886
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LRRC4C mRNAdecreases expression 16443690
C025643 vinclozolin vinclozolin affects the expression of LRRC4C mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5915322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D001008 Anxiety Disorders vinclozolin 4.0019015723
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4316192424 15721981 16124888 15700767 16050911 18705752 10355542 15673190 16011737 16227642 3786805 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5816120746 18670907 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2515668235 15340226 16354765 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.9314966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0610915739 15027814 7440962 7120509 16227642 6623471 21278145 3732212 9327722 6884620 16177239 3786805 19085960 10092053 2869522 7179309 4309450 11566570 17522070 15968718 15998439 19336974
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7716714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.479294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.6512795759 15959796 19224547 16045604 12631006 17595544 16239168 61145
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.8618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.8620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.6816973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.1716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5412621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9115340226 18606429 8697196 16959395 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D007248 Infertility, Male vinclozolin 3.3216467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007984 Leydig Cell Tumor vinclozolin 5.4716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0216943688 11903743 11408273 17157831 21278145 17174718 16221502 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3814724832 17525996 15057751 15818738 18705752 14620537 16116963 13678700 18263696 17869086 18317297 18156304 17944888 14748882 17721639 12389079 17565644 18251166 10355542 18395914 14716833 15338365 16033810 12445421 17900296 16136751 17766677 18412020 18420326 12445418 18279442 18210741 12609069 17698563 18166357 18376398 18481824 18472332 12586293 12649538 18187930 17823541 18339082 17708605 15362042 12632514 18205269 17640975 12741479 15931870 16011737 15876570 15123356 17761835 16027843 18472094 17976157 15673190 15996030 14512876 20821823 17805973 11481614 15370692 15959796 18277467 17922224 14716496 18395095 17714472 16097048 16248980 15052691 12667390 15893842 18418968 15650968 17557913 12632512 12666154 18429990 15730626 16638106 18006644 17631135 12546737 12958196 18054572 16192424 15925388 12898905 17481882 16015684
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1616964402 16246199 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.1414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8419294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.6112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.1011222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 12.1018042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.6818220299
MESH:D011472 Prostatitis vinclozolin 5.6818629315
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
Pathway ID Pathway Name
KEGG:04360 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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