AutismKB 2.0

Annotation Detail for PTPN1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PTPN1 ( PTP1B )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 1
Band: 20q13.13
Quick LinksEntrez ID:5770; OMIM: 176885; Uniprot ID:PTN1_HUMAN; ENSEMBL ID: ENSG00000196396; HGNC ID: 9642
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04520Adherens junction
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200039Calcineurin-regulated NFAT-dependent transcription in lymphocytes
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200012Insulin Pathway
200127PDGFR-beta signaling pathway
200084IGF1 pathway
200085EGF receptor (ErbB1) signaling pathway
200065Signaling events mediated by TCPTP
200180N-cadherin signaling events
Pathway IDPathway Name
P00012Cadherin signaling pathway
Pathway IDPathway Name
500005Integrin alphaIIbbeta3 signaling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
2091Hypertension
2053Colon cancer
2197Metabolism disease
Desease Name
diabetes, type 2 glucose insulin obesity
anthropometric parameters diabetes, type 2 insulin
CARDIOVASCULAR
diabetes or impaired glucose tolerance
type 1 diabetes
glucose tolerance
IMMUNE
atherosclerosis, diabetic
METABOLIC
obesity
insulin
body fat
diabetes, type 2
No data
Desease Name
Insulin resistance, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PTPN1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PTPN1 mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of PTPN1 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of PTPN1 mRNAaffects expression 17562736
D000171 Acrolein Acrolein results in decreased activity of PTPN1 proteindecreases activity 17655273
D000171 Acrolein Vanadates inhibits the reaction [Acrolein results in decreased activity of PTPN1 protein]decreases activity|decreases reaction 17655273
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPN1 mRNAaffects expression 16483693
D000728 Androgens Androgens affects the expression of and affects the activity of PTPN1 proteinaffects activity|affects expression 16652382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPN1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in increased expression of PTPN1 mRNAincreases expression 12075121
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PTPN1 mRNAaffects cotreatment|increases expression 20360939
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PTPN1 proteinaffects cotreatment|increases expression 19509184
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PTPN1 proteinaffects cotreatment|increases expression 19509184
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PTPN1 mRNAaffects cotreatment|increases expression 20360939
D002117 Calcitriol Calcitriol results in increased expression of PTPN1 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PTPN1 mRNAincreases expression 17606305
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTPN1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PTPN1 mRNAincreases expression 12075121
12655037
D005419 Flavonoids Flavonoids results in decreased expression of PTPN1 mRNAdecreases expression 18035473
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PTPN1 proteinaffects cotreatment|increases expression 19509184
D019833 Genistein Genistein results in increased expression of PTPN1 mRNAincreases expression 12075121
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTPN1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PTPN1 mRNAincreases expression 18301758
D012643 Selenium Selenium results in decreased glutathionylation of PTPN1 proteindecreases glutathionylation 19022953
D012643 Selenium Selenium results in increased expression of PTPN1 proteinincreases expression 19022953
C021747 sodium selenate sodium selenate results in increased expression of PTPN1 mRNAincreases expression 16443359
D018038 Sodium Selenite Sodium Selenite results in increased expression of PTPN1 mRNAincreases expression 16443359
D013629 Tamoxifen Tamoxifen affects the expression of PTPN1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTPN1 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN1 mRNAaffects cotreatment|increases expression 17942748
D014638 Vanadates Vanadates inhibits the reaction [Acrolein results in decreased activity of PTPN1 protein]decreases activity|decreases reaction 17655273
D014638 Vanadates Vanadates results in increased expression of PTPN1 proteinincreases expression 17874149
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury Acrolein 8.7020525806 21297076
MESH:D055371 Acute Lung Injury pirinixic acid 8.7018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1914692618
MESH:D000230 Adenocarcinoma Genistein 4.1911473722
MESH:D000236 Adenoma Diethylnitrosamine 2.746695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.1619052882 17162532 19061943 16434500 17620307 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.1616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.1616835633
MESH:D000544 Alzheimer Disease Acrolein 6.8915207723 17570602 14715435
MESH:D000544 Alzheimer Disease Androgens 6.8917917157 17182789
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 6.8920157255
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9810965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001161 Arteriosclerosis Acrolein 22.9015014928
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 22.9015552841
MESH:D001161 Arteriosclerosis Dietary Fats 22.9015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 22.9011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D050197 Atherosclerosis Acrolein 3.8716126721 17363696 16037261
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D001943 Breast Neoplasms Androgens 4.5817018787
MESH:D001943 Breast Neoplasms bisphenol A 4.5817123778
MESH:D001943 Breast Neoplasms Calcitriol 4.5811237771
MESH:D001943 Breast Neoplasms Dietary Fats 4.5820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5817474063
MESH:D001943 Breast Neoplasms Genistein 4.5816873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tamoxifen 4.5811161223 18351453 16818667 19221464 19289846 19142967 20065188 16202921 19059307 18815881 18997820 21152245 19410462 15668708 16273361 20544844 19066611 19115204 19487384 15565566 20390343 17440819 20859285 19189212 17242785 19200415 17049068 19189210 18629630 18855134 18984771 17893378 20005174 16873071 21138602 19084267 18425577 19011961 17261762 19288272 20135344 19103187 19244106 19155303 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.9716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 10.9716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.973084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.9718665156 20214788 19107877 19539802 10672840 3084413 18785209 18210153 16807293 21159647 17162532 16878318 16540662 16569478 19519916 19701751 19383236 19052882 16698587 20727157 18978308 18506893 17055752 16288022 20432363 16779866 10737359 19171122 18494052 17173139 19335982 20524982 19418558 16935385 16830150 20007298 18971187 19822196 20084675 17138121 18056438 17761372 19919837 18788625 18691550 16328049 19208518 16502159 19394651 11831363 3581430 20514400 20935162 18393292 20512989 17978847 16681979 20101231 17428255
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.9716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.9716924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.5711237771
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2616120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.1716332659
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.436135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.4320889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.432727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2817110522 16105132 15861022 16919318 11677210 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 7.2819176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315668235 16354765 12621046 8697196 15340226
MESH:D003092 Colitis Selenium 3.5917936198
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D015179 Colorectal Neoplasms Acrolein 2.9217597105
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D003327 Coronary Disease Fructose 4.3518504504
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D016638 Critical Illness Androgens 5.8716670151
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.2618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.2618551238
MESH:D003556 Cystitis Acrolein 5.2012161096
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6216285004
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.3418603373
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.8920387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 9.8918603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.8916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.8917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.8018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.8019370779 17906064 10774834 19085960 19420014 10663392 19923254 11461765 14550746 12705907 2444490 18713872 16227642 15968718 11834606 16177239 14986274 10915739 12153990 16781746 11529661 19416960 12594235 16109766 12958197 16081117 16393943 14725611 15619225 18071297 11739529 11287661 12392966 19739265 11743745 16485898 19164858 12540782 17522070 11421492 17562736
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.8019107877
MESH:D056486 Drug-Induced Liver Injury Selenium 17.8015131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.8015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.8020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004487 Edema pirinixic acid 5.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7118230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.2815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.2812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.2819031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.4016402032
MESH:D016889 Endometrial Neoplasms Genistein 7.1211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.1219155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Dietary Fats 28.4719004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 28.4720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.4715345470
MESH:D005234 Fatty Liver Fructose 28.4718395287 19196556 18641190
MESH:D005234 Fatty Liver pirinixic acid 28.4719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 28.4714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Dietary Fats 13.8318296743
MESH:D005355 Fibrosis Fructose 13.8318504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8320067830
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005909 Glioblastoma Genistein 3.1416598420
MESH:D018149 Glucose Intolerance Fructose 5.1419165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.5620558911
MESH:D006333 Heart Failure Selenium 6.5617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly pirinixic acid 7.6316221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6315340226 12621046 16120746
MESH:D006628 Hirsutism Androgens 5.8916914592 17019078
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8515340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D017588 Hyperandrogenism Androgens 5.5417019078
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 9.1110876104
MESH:D006937 Hypercholesterolemia Dietary Fats 9.1121332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006946 Hyperinsulinism Fructose 4.7418563319 19008412 18360027 14757778 15752949
MESH:D006949 Hyperlipidemias Dietary Fats 8.9621332399
MESH:D006949 Hyperlipidemias Fructose 8.9615752949
MESH:D006973 Hypertension Fructose 5.2616843071 14568997 14633139 19008412 14573337
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2618850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.9119799862 19342510
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Dietary Fats 14.8120412841
MESH:D007249 Inflammation Diethylnitrosamine 14.8118785209
MESH:D007249 Inflammation Flavonoids 14.8117296493
MESH:D007249 Inflammation Tamoxifen 14.8119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.8112200463 12878042
MESH:D007251 Influenza, Human Selenium 4.0016624496
MESH:D007333 Insulin Resistance bisphenol A 21.8916393666
MESH:D007333 Insulin Resistance Dietary Fats 21.8918457598 11836018
MESH:D007333 Insulin Resistance Fructose 21.8918057795 19342510 18981581 19008412 14573337 14757778 19799862 18563319 17133782 14633139 19586609
MESH:D007333 Insulin Resistance pirinixic acid 21.8916306350
MESH:D007333 Insulin Resistance Sodium Selenite 21.8914714311
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4210783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007674 Kidney Diseases Acetaminophen 9.6812587719 15629191
MESH:D007674 Kidney Diseases Acrolein 9.6812488133
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 9.6815369732
MESH:D007676 Kidney Failure, Chronic Selenium 3.7116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.5116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.5116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 11.5118625569
MESH:D007938 Leukemia Genistein 2.9318980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.8716766008
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2918665156 20032147 19638242 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.7417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7412878042
MESH:D008107 Liver Diseases Acetaminophen 3.7412587719 12969438 19784758 16611625 16610002 11587558 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7417034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.457678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.4519996281 12771043 15175105 20137499 21047994 12112319 19551842 18754104 10737359 19690152 19255062 19073162 18648771 16942905 9163691 19294768 19090486 19499222 20583210 19426721 19642983 19638242 19254457 21278145 20492335 19812893 2862719 20452335 19833225 19427195 20405173 18977376 2422723 18644402 19256749 20501860 20434301 18978307 20118626 15885732 21071580 19850985 21167192 20101389
MESH:D008113 Liver Neoplasms pirinixic acid 13.4515890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 13.4516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.4516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.106135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.1018164116 18282651 18775883 17854601 19009564 21159647 19539802 9362446 18253720 17942915 19126423 19004024 16267830 16842330 18544905 18308698 18079962 19519916 2563599 3124819 18093689 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1012151625
MESH:D008171 Lung Diseases Acrolein 4.0811504702
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.2421163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Tamoxifen 3.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2419555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8814737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.3012929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.3015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.3014580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3519453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.3519513568
MESH:D008546 Melanoma, Experimental Acrolein 10.3510803710
MESH:D008654 Mesothelioma Selenium 2.7215107826
MESH:D024821 Metabolic Syndrome X Fructose 4.6618497449 17098227 16815490 17261469 19165636
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009203 Myocardial Infarction Genistein 5.4117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.7118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.717678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.489029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Acrolein 5.0117329238
MESH:D009369 Neoplasms pirinixic acid 5.0117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119196722 19200415 19189210
MESH:D009393 Nephritis Acrolein 6.0912653641
MESH:D009421 Nervous System Malformations bisphenol A 15.3416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.3416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.2518514411
MESH:D019636 Neurodegenerative Diseases Acrolein 13.2511342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.2520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009765 Obesity Dietary Fats 7.2420518802 21332399 18674790 17217161 18457598 20132043 16723640 19632207 11836018
MESH:D009765 Obesity Fructose 7.2418585860 17707055
MESH:D009765 Obesity pirinixic acid 7.2420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.3316049721
MESH:D010024 Osteoporosis Genistein 3.1419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9116169203
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms Genistein 2.5419005980
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010300 Parkinson Disease Acrolein 6.0717690948
MESH:D010300 Parkinson Disease Cholesterol, Dietary 6.0719014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.8211550810
MESH:D010787 Photosensitivity Disorders Acrolein 12.8211550810
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.392563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8710548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8711896295 11118676 11222880 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0320887781
MESH:D011471 Prostatic Neoplasms Androgens 1.8917909013 16998812 15389811
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8916289102 15754350 18247401 16644109 12479363
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8918760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D051437 Renal Insufficiency Acrolein 4.8212732208
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4418551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D020521 Stroke Acrolein 4.4016269634
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.847505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.8516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.8516049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.8517572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.3510091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014591 Uterine Diseases bisphenol A 4.8214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
Pathway ID Pathway Name
KEGG:04520 Adherens junction
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
REACT:13552 Integrin cell surface interactions
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01133 antagonist Tiludronate Antihypocalcemic Agents;Osteoporosis Prophylactic;Bone Density Conservation Agents
DB01734 - 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid
DB01769 - Double Oxidized Cysteine
DB01820 - Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-Napthylalaniamide
DB01943 - Compound 15
DB02014 - Compound 9
DB02072 - 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid
DB02259 - 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide
DB02420 - [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,
DB02436 - 2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic Acid
DB02615 - Compound 19
DB02620 - Sp7343-Sp7964
DB02622 - 2-(Oxalyl-Amino)-Benzoic Acid
DB02651 - {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)
DB02662 - Novo Nordisk a/S Compound
DB02784 - N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic Acid
DB02827 - 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
DB02977 - PNU177836
DB03102 - 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
DB03122 - B-Octylglucoside Detergents
DB03154 - {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid
DB03311 - 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide
DB03398 - Cysteine Sulfenic Acid
DB03483 - 4-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric Acid
DB03557 - N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic Acid
DB03661 - Cysteinesulfonic Acid
DB03670 - 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
DB03684 - 2-Methyl-2,4-Pentanediol
DB03714 - 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid
DB03982 - Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid
DB04001 - 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
DB04088 - N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)
DB04142 - 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide
DB04184 - Acetate Ion Indicators and Reagents
DB04204 - [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid
DB04285 - {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid
DB04525 - 2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic Acid
DB04800 - 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID
DB06829 - 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID
DB06887 - 3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
DB07130 - 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
DB07134 - 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
DB07197 - 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID
DB07263 - [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
DB07289 - 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID
DB07295 - 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
DB07298 - 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
DB07480 - 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
DB07651 - N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE
DB07719 - 3(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
DB07730 - 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE
DB08001 - 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID
DB08003 - ISOTHIAZOLIDINONE ANALOG
DB08147 - 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid
DB08371 - PARA-(BENZOYL)-PHENYLALANINE
DB08397 - 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
DB08549 - (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
DB08591 - 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
DB08593 - 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE
DB08783 - (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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