AutismKB 2.0

Annotation Detail for PRX


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Basic Information Top
Gene Symbol:PRX ( CMT4F,KIAA1620 )
Gene Full Name: periaxin
Band: 19q13.2
Quick LinksEntrez ID:57716; OMIM: 605725; Uniprot ID:PRAX_HUMAN; ENSEMBL ID: ENSG00000105227; HGNC ID: 13797
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1726Charcot-Marie-Tooth disease
1791Neuropathy
No data
No data
Desease Name
Charcot-Marie-Tooth disease, type 4F
Dejerine-Sottas neuropathy, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PRX mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRX mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in increased expression of PRX mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of PRX mRNAincreases expression 18042831
D012643 Selenium Selenium results in increased expression of PRX mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRX mRNAincreases expression 19933214
C025643 vinclozolin vinclozolin affects the expression of PRX mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 8697196 15668235 15340226 16354765
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Dietary Fats 3.5219004024 17967931 18296743 19551842
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Dietary Fats 9.8418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 16959395 8697196 18606429 15340226
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:C538392 Hypertrophic neuropathy of Dejerine-Sottas marker/mechanism
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Dietary Fats 5.3420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412200463 12878042
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2711836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009765 Obesity Dietary Fats 2.3416723640 18674790 17217161 19632207 20132043 20518802 18457598 21332399 11836018
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8411118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.8419015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33843
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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