AutismKB 2.0

Annotation Detail for PCDHB16


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Basic Information Top
Gene Symbol:PCDHB16 ( KIAA1621,ME1,PCDH-BETA16,PCDH3X,PCDHB8a )
Gene Full Name: protocadherin beta 16
Band: 5q31.3
Quick LinksEntrez ID:57717; OMIM: 606345; Uniprot ID:PCDBG_HUMAN; ENSEMBL ID: ENSG00000196963; HGNC ID: 14546
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PCDHB16 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of PCDHB16 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PCDHB16 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5914514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4316097048 16050911 15721981 16192424 15673190 10355542 15700767 3786805 16011737 18705752 16124888 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5818670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2512621046 16354765 15340226 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.062869522 15027814 16177239 7179309 17522070 15998439 19085960 11566570 15968718 10092053 9327722 16227642 10915739 19336974 21278145 3786805 4309450 3732212 6884620 7440962 7120509 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7718230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.479294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.3616045604 17595544 15959796 61145 12631006 16239168 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 9.3619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 18.9018705752
MESH:D005355 Fibrosis Cyclosporine 18.9012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.9020067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5311294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5412621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.918697196 16959395 15340226 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006973 Hypertension Cyclosporine 5.3910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1212371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0211903743 16943688 21278145 16239168 16221502 17334410 11408273 17174718 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3817698563 12898905 16192424 18277467 12632512 17708605 17631135 14748882 14716833 15338365 18263696 15730626 17565644 17557913 18481824 18251166 14620537 18472332 10355542 18210741 11481614 12546737 17823541 17869086 14724832 12741479 14716496 15931870 15057751 15362042 17721639 15818738 15052691 18395914 16015684 15673190 18279442 17761835 18205269 12586293 12389079 16638106 15893842 18339082 15650968 17805973 13678700 12649538 17525996 18376398 17900296 15996030 14512876 18412020 12445418 16027843 15925388 17714472 18705752 18429990 17944888 17922224 16033810 16248980 12667390 12632514 16116963 18054572 17766677 18472094 12958196 15123356 17640975 17481882 12445421 16136751 18006644 15370692 15876570 16097048 16011737 17976157 12666154 20821823 18418968 12609069 18187930 18395095 18156304 18420326 18166357 18317297 15959796
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1615830285 16964402 15720792 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.1416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8419294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.6112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311896295 11399792 11118676 11222880
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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