AutismKB 2.0

Annotation Detail for WDR19


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Basic Information Top
Gene Symbol:WDR19 ( DYF-2,FLJ23127,IFT144,KIAA1638,ORF26,Oseg6,PWDMP )
Gene Full Name: WD repeat domain 19
Band: 4p14
Quick LinksEntrez ID:57728; OMIM: 608151; Uniprot ID:WDR19_HUMAN; ENSEMBL ID: ENSG00000157796; HGNC ID: 18340
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of WDR19 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of WDR19 mRNAdecreases expression 20458559
C006780 bisphenol A bisphenol A results in decreased expression of WDR19 mRNAdecreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of WDR19 mRNA]affects reaction|decreases expression 17706920
D016572 Cyclosporine Cyclosporine results in increased expression of WDR19 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of WDR19 mRNAaffects expression 17555576
D012402 Rotenone Rotenone results in increased expression of WDR19 mRNAincreases expression 19013527
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of WDR19 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of WDR19 mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of WDR19 mRNAaffects expression 17555576
D014635 Valproic Acid Valproic Acid results in increased expression of WDR19 mRNAincreases expression 19101580
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of WDR19 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of WDR19 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4119825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 18177632 18316065 18985861 18558336 18940202 17157402 15238991 18396377 16609825 17688650 19232924 18775368 19460635 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001943 Breast Neoplasms bisphenol A 2.2217123778
MESH:D001943 Breast Neoplasms Tamoxifen 2.2216202921 20544844 18629630 20859285 18351453 17242785 16273361 19115204 19142967 15668708 18855134 17893378 19155303 19189210 20135344 19410462 11161223 20065188 19059307 19011961 19244106 17440819 19103187 19221464 19084267 19066611 19289846 19487384 18815881 17261762 21152245 16873071 19200415 18821012 18997820 20005174 18984771 19189212 21138602 19288272 17049068 16818667 20390343 15565566 18425577
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6715553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2017333356 17110522 16105132 15861022 16919318 11677210 17681005
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9510525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9516575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9519769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4912594235 19739265 2444490 15968718 16109766 19420014 19923254 12153990 11421492 19085960 12958197 12540782 14986274 11287661 16485898 11461765 11834606 17906064 16227642 14550746 16081117 11739529 17562736 19416960 17522070 14725611 16393943 18071297 19164858 10774834 19370779 12705907 15619225 10663392 12392966 10915739 11743745 16177239 16781746 18713872 11529661
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4915131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.491733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1517893378 19155303 20544844 16202921
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005234 Fatty Liver arsenic trioxide 26.6115073043
MESH:D005234 Fatty Liver Cyclosporine 26.6119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.6115345470
MESH:D005234 Fatty Liver Tamoxifen 26.6119224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 26.6119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tamoxifen 2.4319457130
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance bisphenol A 3.3916393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.558314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.5512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7818625569
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0016467208 20471514 19850784 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3219225113 16112521 16966277 19642359 15748426 17107899 19075265 9834237 15622746 17217047 12679006 12712474 16891316 12018890 11161223 11468182 17649720 17712046 16330433 15336539 15213294 19035177 16823087 17869043 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5718564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5716169303
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 16611625 16610002 12969438 19784758 11587558 19460945 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8114682389
MESH:D008113 Liver Neoplasms Tamoxifen 4.8116684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5611798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 3.5618625569
MESH:D008175 Lung Neoplasms Vitamin E 3.5611062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4019196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 11468182 15949261 19417148 19549372
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7216882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7217596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 4.0115790535 18619942 17356569
MESH:D009421 Nervous System Malformations bisphenol A 4.1716427766 11399458
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6910525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.698888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4519769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010300 Parkinson Disease Rotenone 3.0311535288 16412576 18191903 19232380 11445065 18619942 19114014 15451049 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.2418197244 15927086 15795934 15574749
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.5510548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5520603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0619131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0616740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8514763951 11044598 1511512 15475178 11738929 3137016 16876388 17978042
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3012845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3016712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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