AutismKB 2.0

Annotation Detail for SCUBE2


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Basic Information Top
Gene Symbol:SCUBE2 ( CEGB1,CEGF1,CEGP1,FLJ16792,FLJ35234,MGC133057 )
Gene Full Name: signal peptide, CUB domain, EGF-like 2
Band: 11p15.4
Quick LinksEntrez ID:57758; OMIM: 611747; Uniprot ID:SCUB2_HUMAN; ENSEMBL ID: ENSG00000175356; HGNC ID: 30425
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003520 Cyclophosphamide SCUBE2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004041 Dietary Fats Dietary Fats results in increased expression of SCUBE2 mRNAincreases expression 18042831
D004317 Doxorubicin SCUBE2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D005472 Fluorouracil SCUBE2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D017239 Paclitaxel SCUBE2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C041786 palm oil palm oil results in increased expression of SCUBE2 mRNAincreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 4.8317418594
MESH:D000230 Adenocarcinoma Fluorouracil 4.8317638652
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D000740 Anemia Fluorouracil 4.0217963324 16511603 15504547
MESH:D001161 Arteriosclerosis Cyclophosphamide 11.7615014928
MESH:D001161 Arteriosclerosis Dietary Fats 11.7615238619
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.9215867366
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.4515136595 11325840 15093573 18323546 17020986 17388661 16978400 18234424 12006526
MESH:D001943 Breast Neoplasms Dietary Fats 2.4520435547
MESH:D001943 Breast Neoplasms Doxorubicin 2.4515692762 16115903 18234424 19526202 16322301 17369602 17426702 15939500 18382427 16096432 15993339 18628466 15567936 17983394 11325840 16264153 15136595 18695136 16826403 15668708 16935488 15994142 15634643 16595493
MESH:D001943 Breast Neoplasms Fluorouracil 2.4518357371 16557594 19217205 16595493 16110121 15136595 18608205
MESH:D001943 Breast Neoplasms Paclitaxel 2.4516115903 15136595 18234424 16244791 11325840 18323546 18223236 16273361
MESH:D002276 Carcinoid Tumor Doxorubicin 14.1516051944
MESH:D002276 Carcinoid Tumor Fluorouracil 14.1516051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 7.0219701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 7.0218059187 16023760 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 7.0216799960 17045692 16332177 17088986 18930000 17971768
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 7.0216313753
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.3516152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 11.6416201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.641485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 11.6418695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.106189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.1016280240 17066447 18986760 16757204
MESH:D009202 Cardiomyopathies Doxorubicin 3.7216109756 15476868 16952015 16364871 17974986 17351982 17928571 16731534 15792986 18627295 16242529 16651473 17382496 17007740 17924179 16612575 16269455 17131338 16278810 17308081 15505089 17329180 15811867 17519947 16455267
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0316243910 17334414
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717725105 18772588 15001691 17169374 16510598 17016597 16340194 17287894 17018589 17172411
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6818259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6817094418 20501625 15289873 16303861 17016601 18802399 17255274 18383874 17594712 18509181 16331619 16391804 17401013 16524972 14970324 17695437 18448328 17454858 15148649 16282729 18949393 18288408
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.6818802399
MESH:D003556 Cystitis Cyclophosphamide 5.5112913760 15276878 16651033 18372110 16614059 12388444 18433785 18483878 10498854 18295254 18093676 10700343 16413132 16989017 17010015 11948286 18710439 17979934 15643279 12161096
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.3311751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2918772604
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5117416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9018602426
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6417359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.6311006010
MESH:D004938 Esophageal Neoplasms Fluorouracil 5.0316337965 16481741 16785472 17638652 15173087
MESH:D004938 Esophageal Neoplasms Paclitaxel 5.0316481741
MESH:D005234 Fatty Liver Dietary Fats 3.5619004024 18296743 19551842 17967931
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005909 Glioblastoma Doxorubicin 3.5417150277
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.9811389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.4511014644 16376943 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.6015692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.6018337622 15162350 15102660
MESH:D006331 Heart Diseases Doxorubicin 3.6916330681 16244371 16244372 18006777 16879835 16144979 12587719 17888722 16495754 17875725 16707910 18674790 14766674
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.7111918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 6.0514986274
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.6716135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 8.6717606976 15147373 18501091
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007154 Immune System Diseases Cyclophosphamide 5.8516076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.8216517039 7193160
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3018457598 11836018
MESH:D007674 Kidney Diseases Doxorubicin 3.2115369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D007938 Leukemia Cyclophosphamide 3.6210602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.6118587576 17802794 17008537 18172266 17296974 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.3210373061
MESH:D007970 Leukopenia Cyclophosphamide 5.4310052129 11830472
MESH:D008080 Liposarcoma Paclitaxel 5.1717353645
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516595196 16439617
MESH:D008113 Liver Neoplasms Fluorouracil 2.5716603448 17045692 15113037 18383874
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1917085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.7517418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 2.7515246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008223 Lymphoma Cyclophosphamide 8.6212854902
MESH:D008223 Lymphoma Doxorubicin 8.6216098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.9516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 16.2911911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 16.2917654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 16.2914749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2115458769
MESH:D008545 Melanoma Doxorubicin 3.8116827129
MESH:D008545 Melanoma Paclitaxel 3.8112025231 16342250 12040289
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.2216388313
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8718986760 16757204
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.9014749477
MESH:D009203 Myocardial Infarction Doxorubicin 3.0519429709 15857846
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.4818259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.4815867366
MESH:D009369 Neoplasms Cyclophosphamide 5.8718854779
MESH:D009369 Neoplasms Fluorouracil 5.8718239605 18600527 16928823
MESH:D009401 Nephrosis Doxorubicin 5.1916899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2916889571 15640375
MESH:D009447 Neuroblastoma Cyclophosphamide 7.6916115947 8761367 15176712
MESH:D009447 Neuroblastoma Doxorubicin 7.6915555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.358761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009503 Neutropenia Cyclophosphamide 4.688291058
MESH:D009765 Obesity Dietary Fats 2.3420132043 17217161 19632207 21332399 18674790 18457598 11836018 16723640 20518802
MESH:D009845 Oligospermia Cyclophosphamide 5.1716517039
MESH:D010014 Osteolysis Paclitaxel 5.4415867366
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0611161223
MESH:D010146 Pain Cyclophosphamide 3.8912161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.9211332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.9219003803 16929163 16500647 15113037
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9621297632
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1317136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1318437689 16888761 15897917 15749863 16729912 16868541
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1319082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.1317172428 16729912 16356831 17136230
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3816636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3016160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D012509 Sarcoma Doxorubicin 4.2916767912 17203757 15625365 15675481 17710206 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.1716636934
MESH:D012878 Skin Neoplasms Doxorubicin 3.0815692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9817203757 16767912 15625365
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.9816517039
MESH:D013274 Stomach Neoplasms Fluorouracil 2.8118396642 19084572 18567086 17498489 17522103 16951190 17172411 15786421 19015929 16424979
MESH:D013274 Stomach Neoplasms Paclitaxel 2.8118506536 18396642
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.5212837982
MESH:D024801 Tauopathies Paclitaxel 5.2716930453
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6117909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.8414692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.8417653716
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417678736 17334414 17638931 16364871
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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