AutismKB 2.0

Annotation Detail for ANKRA2


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Basic Information Top
Gene Symbol:ANKRA2 ( ANKRA )
Gene Full Name: ankyrin repeat, family A (RFXANK-like), 2
Band: 5q13.2
Quick LinksEntrez ID:57763; OMIM: 605787; Uniprot ID:ANRA2_HUMAN; ENSEMBL ID: ENSG00000164331; HGNC ID: 13208
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200019Signaling events mediated by HDAC Class II
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ANKRA2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ANKRA2 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ANKRA2 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ANKRA2 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ANKRA2 mRNAincreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ANKRA2 mRNAincreases expression 20382639
D012643 Selenium Selenium results in decreased expression of ANKRA2 mRNAdecreases expression 19244175
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of ANKRA2 mRNAdecreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.9715814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2319898480
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7921507988 12619106 12907637
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.5011212258
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.1320419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.1311212258
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.266135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6615131321
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4618590791
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.967678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.969163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.512876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.518603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.7014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.7018816296 20464547 20869020 17053015 20064080 20135361 18569708 6695378 18520028
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.703440675 16288123 12111688 11091918
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.5116381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.5115006635
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.9818410779
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.4010029692 19755658
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.4018590791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.7316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.7316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.7317053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 12.7312846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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