AutismKB 2.0

Annotation Detail for PTPN7


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Basic Information Top
Gene Symbol:PTPN7 ( BPTP-4,HEPTP,LC-PTP,LPTP,PTPNI )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 7
Band: 1q32.1
Quick LinksEntrez ID:5778; OMIM: 176889; Uniprot ID:PTN7_HUMAN; ENSEMBL ID: ENSG00000143851; HGNC ID: 9659
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200184Downstream signaling in naive CD8+ T cells
200088Ras signaling in the CD4+ TCR pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPN7 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of PTPN7 mRNAaffects cotreatment|affects expression 18636392
D003474 Curcumin Curcumin results in increased expression of PTPN7 mRNAincreases expression 17198877
D005419 Flavonoids Flavonoids results in decreased expression of PTPN7 mRNAdecreases expression 18035473
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of PTPN7 mRNAaffects cotreatment|affects expression 18636392
D013752 Tetracycline Tetracycline results in increased expression of PTPN7 mRNAincreases expression 16917069
C030665 triphenyltin triphenyltin results in decreased expression of PTPN7 mRNAdecreases expression 12788061
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury Chlorine 4.6320601635
MESH:D019973 Alcohol-Related Disorders Curcumin 5.5217887948
MESH:D000544 Alzheimer Disease Curcumin 4.5815590663
MESH:D000544 Alzheimer Disease Ozone 4.5815513908
MESH:D001172 Arthritis, Rheumatoid Curcumin 5.0216807698
MESH:D001172 Arthritis, Rheumatoid Ozone 5.0215570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D050197 Atherosclerosis Curcumin 3.4718704882
MESH:D001327 Autoimmune Diseases Curcumin 4.8519761891
MESH:D002545 Brain Ischemia Curcumin 4.7316770732
MESH:D001932 Brain Neoplasms Curcumin 4.2017596214
MESH:D001943 Breast Neoplasms Curcumin 2.7119250217 16243823 18593918 18462866
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9017626835 15516495 16777450 18315731 14754758 18417511 19059883
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D002277 Carcinoma Curcumin 4.0618593918
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0518414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D003092 Colitis Curcumin 4.5316804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.8318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5416340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 5.2618497527
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.2618204486
MESH:D056486 Drug-Induced Liver Injury Tetracycline 2.9817522070
MESH:D004381 Duodenal Ulcer Curcumin 4.3817351913
MESH:D004417 Dyspnea Chlorine 5.0720016425
MESH:D005234 Fatty Liver Curcumin 9.3019297423
MESH:D005234 Fatty Liver Tetracycline 9.3016917069 19224547
MESH:D005355 Fibrosis Curcumin 4.3418705752
MESH:D005739 Gas Poisoning Chlorine 5.4520016425
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0518462866
MESH:D005909 Glioblastoma Curcumin 3.6417596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8318462866 18829502
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4017701891
MESH:D006937 Hypercholesterolemia Curcumin 4.3318704882
MESH:D006943 Hyperglycemia triphenyltin 5.9310522495
MESH:D015228 Hypertriglyceridemia triphenyltin 6.2210522495
MESH:D007246 Infertility triphenyltin 6.3515205045
MESH:D007249 Inflammation Curcumin 5.8117151092 16956363 18403477
MESH:D007249 Inflammation Flavonoids 5.8117296493
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3018596194 18200517
MESH:D007414 Intestinal Neoplasms Curcumin 4.4810783313
MESH:D007889 Leiomyoma Curcumin 4.8818555241
MESH:D007938 Leukemia Curcumin 3.3618462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4916106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0916106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2817355460 18006644 18705752
MESH:D008107 Liver Diseases Curcumin 2.6616956363
MESH:D008171 Lung Diseases Ozone 3.558266340 19066396
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms Curcumin 2.8216243823 19359593 18462866
MESH:D008175 Lung Neoplasms Ozone 2.828597069 7614698
MESH:D008223 Lymphoma Curcumin 3.7818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0516173963
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.4817263510
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D009101 Multiple Myeloma Curcumin 3.7019372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3117962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7018495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9812497104
MESH:D009395 Nephritis, Interstitial Tetracycline 5.239884423
MESH:D009423 Nervous System Neoplasms Curcumin 6.0718462866
MESH:D009765 Obesity Curcumin 2.8019297423
MESH:D010024 Osteoporosis Curcumin 3.6218719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8818462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0119401701 19196508 17440100
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.8811026799
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D011014 Pneumonia Ozone 4.7918007984 18929643 18381685
MESH:D017096 Prion Diseases Tetracycline 5.8110903871
MESH:D011471 Prostatic Neoplasms Curcumin 3.6410851300 11398177 18226269 15129424 18769126 12497104 18156803
MESH:D011656 Pulmonary Emphysema Curcumin 4.7919168576
MESH:D012120 Respiration Disorders Chlorine 5.6518579056
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.3318379247 10666014
MESH:D012509 Sarcoma Curcumin 4.3818462866
MESH:D018805 Sepsis Curcumin 4.3118389075
MESH:D013276 Stomach Ulcer Curcumin 3.7719188055 16631530
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9818593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.6618462866
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34003
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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