AutismKB 2.0

Annotation Detail for RAB40C


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Basic Information Top
Gene Symbol:RAB40C ( RARL,RASL8C )
Gene Full Name: RAB40C, member RAS oncogene family
Band: 16p13.3
Quick LinksEntrez ID:57799; OMIM: NA; Uniprot ID:RB40C_HUMAN; ENSEMBL ID: ENSG00000197562; HGNC ID: 18285
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of RAB40C mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RAB40C mRNAincreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAB40C mRNAdecreases expression 19150397
D004958 Estradiol Estradiol results in increased expression of RAB40C mRNAincreases expression 19429434
D005996 Nitroglycerin Nitroglycerin results in increased expression of RAB40C mRNAincreases expression 12187120
D020849 Raloxifene Raloxifene results in increased expression of RAB40C mRNAincreases expression 19429434
D013629 Tamoxifen Tamoxifen results in increased expression of RAB40C mRNAincreases expression 19429434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D000419 Albuminuria Raloxifene 4.9217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Estradiol 1.9414630087 18497071 16675129 17261762 12948864 19861407 17018787 17289903
MESH:D001943 Breast Neoplasms Raloxifene 1.9416837676 17049068 15775269 15758505 17952589 17893378 17595753 16912660 17242785 17440819 17261762 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 1.9416202921 19200415 18351453 21138602 19142967 17261762 18629630 21152245 18815881 19288272 19084267 18997820 20135344 15668708 11161223 18821012 19103187 19410462 18855134 20065188 17893378 17049068 19189210 15565566 19011961 19487384 19221464 16873071 19155303 18425577 19244106 17440819 19059307 18984771 19189212 20005174 16273361 17242785 20390343 19115204 20544844 16818667 19289846 20859285 19066611
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.773581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7716924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.4017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.267505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.2618566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3519486331 9022650
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1514531868 11298694 18759878 2524372 8156756 8970840 11906362 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 16.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.5217451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.5219279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.026679447 7440962 11289319 16192314 9328219 1440618 8291058 18692083 9653073 18289764 18648102 9022650 6482804
MESH:D004487 Edema Raloxifene 3.6115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.3619031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.9611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9616202921 17893378 19155303 20544844
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5820426865
MESH:D005234 Fatty Liver Raloxifene 8.9417473493
MESH:D005234 Fatty Liver Tamoxifen 8.9414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006261 Headache Nitroglycerin 5.6311554966 11284996
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Raloxifene 2.9517577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.816582329
MESH:D007680 Kidney Neoplasms Estradiol 13.8115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 13.8118625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5118564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3016684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.691399818 3712494 6587162 598648
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5311408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5311731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008708 Methemoglobinemia Nitroglycerin 5.043537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.4514659530
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D009203 Myocardial Infarction Nitroglycerin 3.8814729435
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.013581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 3.9816427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010024 Osteoporosis Raloxifene 3.5519059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317893378 17823083 15579764 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5416220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096587162 1399818 7505956 6582329 3712494
MESH:D013978 Tibial Fractures Estradiol 15.2419048282
MESH:D013978 Tibial Fractures Raloxifene 15.2419048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.908074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.9017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.908653321 17572228 16712894
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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