AutismKB 2.0

Annotation Detail for PTPN9


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Basic Information Top
Gene Symbol:PTPN9 ( MEG2,PTPMEG2 )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 9
Band: 15q24.2
Quick LinksEntrez ID:5780; OMIM: 600768; Uniprot ID:PTN9_HUMAN; ENSEMBL ID: ENSG00000169410; HGNC ID: 9661
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PTPN9 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PTPN9 mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in increased expression of PTPN9 mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased expression of PTPN9 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of PTPN9 mRNA]affects reaction|decreases expression 19363521
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN9 mRNAaffects cotreatment|increases expression 17942748
D010634 Phenobarbital Phenobarbital results in decreased expression of PTPN9 mRNAdecreases expression 19270015
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPN9 mRNAaffects cotreatment|increases expression 17942748
D014415 Tunicamycin Tunicamycin results in decreased expression of PTPN9 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms decitabine 2.0718320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7620007298 20935162 17173139 1701930 6705139
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.116135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 8.3719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3716919318 11677210 16105132 17333356 17681005 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 16354765 12621046 15340226
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.2511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.4019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Cyclosporine 9.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Phenobarbital 9.4816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4816120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 8697196 16354765 15340226 16959395
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male decitabine 7.2317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2317937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5712371664
MESH:D007938 Leukemia decitabine 3.1819235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2419117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4117679729 19010910 18460780 18206229 18704418 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.857678174
MESH:D008113 Liver Neoplasms Phenobarbital 7.8519073162 21047994 8742319 19482888 15975961 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.636135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.632563599 17172636 6150874 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119157545 18608210 19010910 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009369 Neoplasms decitabine 2.8119116145 17925555 19470736
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010051 Ovarian Neoplasms decitabine 2.7119331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 5.6319294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.6912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.692563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11399792 11222880 11896295
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012640 Seizures 2,4-dinitrotoluene 10.7518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.7518551238
MESH:D012640 Seizures Phenobarbital 10.753137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms decitabine 7.9217967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.921399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.8217616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34005
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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