AutismKB 2.0

Annotation Detail for HES4


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Basic Information Top
Gene Symbol:HES4 ( bHLHb42 )
Gene Full Name: hairy and enhancer of split 4 (Drosophila)
Band: 1p36.33
Quick LinksEntrez ID:57801; OMIM: 608060; Uniprot ID:HES4_HUMAN; ENSEMBL ID: ENSG00000188290; HGNC ID: 24149
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HES4 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HES4 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of HES4 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of HES4 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.5411473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0217289903 17018787 12948864 16675129 14630087 18497071 17261762 19861407
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1821507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1816924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4618566989
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D016889 Endometrial Neoplasms Estradiol 3.2218566989 11473722 19148513
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005234 Fatty Liver Cyclosporine 3.2819224547
MESH:D005355 Fibrosis Cyclosporine 3.7012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007333 Insulin Resistance Estradiol 3.2116627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.6218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4412371664
MESH:D007680 Kidney Neoplasms Estradiol 8.4415610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.979163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9721137059 20195826
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.968603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5018569708 20869020 18816296 6695378 20464547 18520028 17053015 20064080 20135361
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7911408345 11807958 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 4.1611399458 16427766
MESH:D010051 Ovarian Neoplasms Estradiol 2.3119401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0317292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5219755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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