AutismKB 2.0

Annotation Detail for PTPN11


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Basic Information Top
Gene Symbol:PTPN11 ( BPTP3,CFC,MGC14433,NS1,PTP-1D,PTP2C,SH-PTP2,SH-PTP3,SHP2 )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 11
Band: 12q24.13
Quick LinksEntrez ID:5781; OMIM: 176876; Uniprot ID:PTN11_HUMAN; ENSEMBL ID: ENSG00000179295; HGNC ID: 9644
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04920Adipocytokine signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04630Jak-STAT signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa05220Chronic myeloid leukemia
Pathway IDPathway Name
Axon guidance
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Hemostasis
Signaling by EGFR
Cell junction organization
Signaling by Insulin receptor
Signaling by PDGF
Signaling by FGFR
Signaling in Immune system
Pathway IDPathway Name
200189FGF signaling pathway
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200003Fc-epsilon receptor I signaling in mast cells
200128Neurotrophic factor-mediated Trk receptor signaling
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200157EPO signaling pathway
200151VEGFR1 specific signals
200015GMCSF-mediated signaling events
200012Insulin Pathway
200158IL2 signaling events mediated by STAT5
200127PDGFR-beta signaling pathway
200124IL6-mediated signaling events
200082IL2-mediated signaling events
200083CXCR4-mediated signaling events
200084IGF1 pathway
200085EGF receptor (ErbB1) signaling pathway
200066Angiopoietin receptor Tie2-mediated signaling
200099IL2 signaling events mediated by PI3K
200161Signaling events mediated by VEGFR1 and VEGFR2
200119ErbB2/ErbB3 signaling events
200110IFN-gamma pathway
200109Integrins in angiogenesis
200022TCR signaling in naive CD4+ T cells
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
P00005Angiogenesis
P00021FGF signaling pathway
Pathway IDPathway Name
500514Gab1 signalosome
500306Tie2 Signaling
500307PECAM1 interactions
500305Cell surface interactions at the vascular wall
500090Netrin mediated repulsion signals
500487CTLA4 inhibitory signaling
500248FRS2-mediated cascade
500509Down-stream signal transduction
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1759Skin cancer
1850Herpes
1858Hemorrhagic disorder
1860Brain tumor
1975Congenital heart disease
2004Solid tumor
2051Leukemia
2052Infection
2103Lymphoproliferative disorder
2201Myeloproliferative disease
2207Deafness
Desease Name
HEMATOLOGICAL
heart anomalies, congenital
gastric atrophy
CARDIOVASCULAR
plasma HDL cholesterol (HDL-C) levels
CANCER
Noonan syndrome
type 1 diabetes
stomach cancer
hematological parameters
IMMUNE
METABOLIC
stomach atrophy
Leukemia, Myeloid, Acute
leukemia
DEVELOPMENTAL
Desease Name
Type 1 diabetes
Hematological parameters
Desease Name
Noonan-like/multiple giant cell lesion syndrome
Leopard syndrome
Noonan syndrome 1
Leukemia, juvenile myelomonocytic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PTPN11 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PTPN11 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased activity of PTPN11 proteindecreases activity 17272397
D000082 Acetaminophen Acetaminophen affects the expression of PTPN11 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPN11 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PTPN11 mRNAdecreases expression 19763917
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPN11 mRNAdecreases expression 19150397
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of PTPN11 mRNAaffects cotreatment|decreases expression 18636392
D003474 Curcumin Curcumin results in decreased expression of PTPN11decreases expression 18462866
D016572 Cyclosporine Cyclosporine results in decreased expression of PTPN11 mRNAdecreases expression 20106945
C007517 diphenyleneiodonium diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein]decreases reaction|increases oxidation 16391241
C056507 gemcitabine gemcitabine affects the expression of PTPN11 mRNAaffects expression 17039268
C078131 GM 6001 GM 6001 affects the reaction [PTPN11 protein affects the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]]affects reaction|increases activity|increases phosphorylation 16261333
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of PTPN11 mRNAdecreases expression 12057914
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of PTPN11 mRNAaffects cotreatment|decreases expression 18636392
C006253 pirinixic acid pirinixic acid results in increased expression of PTPN11 mRNAincreases expression 12832660
C059514 resveratrol PTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 15849355
C059514 resveratrol resveratrol results in increased activity of PTPN11 proteinincreases activity 15849355
C017947 sodium arsenite sodium arsenite results in decreased expression of PTPN11 mRNAdecreases expression 12679051
C025643 vinclozolin vinclozolin affects the expression of PTPN11 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D058186 Acute Kidney Injury resveratrol 3.7916538975
MESH:D055371 Acute Lung Injury Chlorine 14.9720601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 14.9711850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 14.9718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2711798837 19825857
MESH:D000236 Adenoma resveratrol 3.2815688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4216434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8516712894 17306315
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0317887948
MESH:D000544 Alzheimer Disease Curcumin 6.6515590663
MESH:D000544 Alzheimer Disease Ozone 6.6515513908
MESH:D000544 Alzheimer Disease resveratrol 6.6516162502 16183991
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5819015723
MESH:D001169 Arthritis, Experimental resveratrol 3.4617115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7916807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7915570426
MESH:D001249 Asthma Ozone 2.6217854713 16373670
MESH:D050197 Atherosclerosis Curcumin 6.7918704882
MESH:D050197 Atherosclerosis resveratrol 6.7916873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Curcumin 4.4319761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.7916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7919483382
MESH:D002545 Brain Ischemia Curcumin 10.1216770732
MESH:D002545 Brain Ischemia resveratrol 10.1217600658
MESH:D001932 Brain Neoplasms Curcumin 3.8817596214
MESH:D001943 Breast Neoplasms Curcumin 2.1819250217 16243823 18462866 18593918
MESH:D001943 Breast Neoplasms gemcitabine 2.1818382427 17039268
MESH:D001943 Breast Neoplasms resveratrol 2.1816393696 17651959 17534123
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6218315731 17626835 18417511 19059883 16777450 15516495 14754758
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002100 Cachexia Ozone 4.6816183385
MESH:D002277 Carcinoma Curcumin 3.7818593918
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.2616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.2616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.263084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.2615073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular resveratrol 11.2619321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.2616507464 17306315 15276417
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5316675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9518414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.5518462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.5516227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.5518572023
MESH:C535579 Cardiofaciocutaneous syndrome marker/mechanism 17703371
MESH:D002318 Cardiovascular Diseases resveratrol 3.4315458977
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.636135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.6320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.6312371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.6319524636 20056578
MESH:D002779 Cholestasis Cyclosporine 7.5919486331
MESH:D002779 Cholestasis pirinixic acid 7.5919176532
MESH:D003092 Colitis Curcumin 9.5916782535 16804969 18200517
MESH:D003092 Colitis resveratrol 9.5916474422
MESH:D003103 Coloboma Curcumin 4.4918809619
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D003110 Colonic Neoplasms Curcumin 3.9719359593 16340194
MESH:D003110 Colonic Neoplasms resveratrol 3.9716338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6120501625
MESH:D015179 Colorectal Neoplasms resveratrol 2.6116550006
MESH:D016510 Corneal Neovascularization Curcumin 4.8318497527
MESH:D003327 Coronary Disease resveratrol 3.7116507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D056685 Costello Syndrome marker/mechanism 17703371
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.6818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.6818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7116873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6918403477
MESH:D003928 Diabetic Nephropathies Curcumin 9.0518204486
MESH:D003928 Diabetic Nephropathies resveratrol 9.0516286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.0621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.0618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0619416960 16177239 11461765 10915739 12540782 2444490 14725611 19923254 18713872 11421492 12392966 16081117 16485898 12705907 14550746 11287661 10774834 19739265 10663392 12958197 16781746 16227642 11529661 15619225 11739529 14986274 19370779 17906064 17562736 19420014 12153990 17522070 11743745 12594235 16393943 18071297 11834606 19164858 19085960 15968718 16109766
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004381 Duodenal Ulcer Curcumin 3.9817351913
MESH:D004417 Dyspnea Chlorine 4.5720016425
MESH:D004487 Edema pirinixic acid 6.7012083418
MESH:D004487 Edema resveratrol 6.708985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.9617872969
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 4.0719148513
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3317637181 15821434 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7817923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4012903497
MESH:D005234 Fatty Liver arsenic trioxide 18.2815073043
MESH:D005234 Fatty Liver Curcumin 18.2819297423
MESH:D005234 Fatty Liver Cyclosporine 18.2819224547
MESH:D005234 Fatty Liver pirinixic acid 18.2819236843 20131406
MESH:D005334 Fever Lipopolysaccharides 3.9511852909 9205823
MESH:D005355 Fibrosis Curcumin 8.6518705752
MESH:D005355 Fibrosis Cyclosporine 8.6512168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005739 Gas Poisoning Chlorine 4.9520016425
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6318462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Curcumin 3.4317596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.6118462866 18829502
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3216366002
MESH:D006529 Hepatomegaly pirinixic acid 2.9318467677 19772884 16221962 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9817701891
MESH:D006561 Herpes Simplex resveratrol 4.1216876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.1012676792
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006937 Hypercholesterolemia Curcumin 9.1818704882
MESH:D006937 Hypercholesterolemia resveratrol 9.1817188708
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006949 Hyperlipidemias resveratrol 3.9616873680
MESH:D006973 Hypertension Cyclosporine 2.0710903974
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2417488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5817600658
MESH:D007248 Infertility, Male sodium arsenite 6.7015346721 12646999
MESH:D007248 Infertility, Male vinclozolin 6.7016467254
MESH:D007249 Inflammation Curcumin 8.3416956363 18403477 17151092
MESH:D007249 Inflammation Lipopolysaccharides 8.3417237260 12878042 17963957 9205823 17255318
MESH:D007249 Inflammation resveratrol 8.3416366677
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1818200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.4916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.1610783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5717255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.7812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.788314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 9.7820008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.0416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.0412371664
MESH:D007889 Leiomyoma Curcumin 4.5118555241
MESH:D044542 LEOPARD Syndrome marker/mechanism 17603483
MESH:D007938 Leukemia marker/mechanism 15273746
MESH:D007938 Leukemia arsenic trioxide 6.4015070760
MESH:D007938 Leukemia Curcumin 6.4018462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.5617077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.5616106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1319850784 20471514 16968895 17050201 16467208
MESH:D054429 Leukemia, Myelomonocytic, Juvenile marker/mechanism
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.6415213294 17649720 11161223 9834237 15336539 19035177 12679006 12018890 16966277 17712046 17869043 11468182 15622746 17217047 16330433 16823087 19075265 16112521 16331271 12712474 19225113 19642359 15748426 16891316 17107899
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.6416087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.5016882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.5016106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.6415821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.5518705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5512878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0419460945 19784758 12587719 16611625 16610002 12969438 19014921 11587558
MESH:D008107 Liver Diseases Curcumin 4.0416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.997678174
MESH:D008113 Liver Neoplasms arsenic trioxide 13.9914682389
MESH:D008113 Liver Neoplasms pirinixic acid 13.9920007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 13.9919812893 19073162 20405173 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 13.9916712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.822876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.8220377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D008171 Lung Diseases Ozone 7.3719066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.3719095001
MESH:D055370 Lung Injury Lipopolysaccharides 9.0321114838
MESH:D055370 Lung Injury Ozone 9.0320417186
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8411798837 19825857
MESH:D008175 Lung Neoplasms Curcumin 4.8419359593 18462866 16243823
MESH:D008175 Lung Neoplasms Ozone 4.847614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 4.8417077188 16712894 19931552 17306315 15276417
MESH:D008223 Lymphoma Curcumin 3.5418462866
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8114749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6316173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1915688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.078985016 11606380
MESH:D008545 Melanoma Curcumin 5.1617885582 18462866
MESH:D008545 Melanoma resveratrol 5.1617992120
MESH:D008545 Melanoma sodium arsenite 5.1619082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008569 Memory Disorders Curcumin 4.0917263510
MESH:D008659 Metabolic Diseases resveratrol 4.3117112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D008679 Metaplasia Ozone 5.0510496685
MESH:D009101 Multiple Myeloma arsenic trioxide 11.9319549372 14977855 19417148 15949261 11468182
MESH:D009101 Multiple Myeloma Curcumin 11.9319372569
MESH:D009101 Multiple Myeloma resveratrol 11.9316490592 17164350 16267019 17049120 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal Curcumin 12.2117962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 12.2117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1016882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 5.6519151258
MESH:D009203 Myocardial Infarction resveratrol 5.6516525036 17125593 16317513 16456233 17188708 17015251
MESH:D017202 Myocardial Ischemia resveratrol 3.9517015251 17125593
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009205 Myocarditis resveratrol 4.7017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.1418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.1418551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.1116624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.1118495463
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009369 Neoplasms pirinixic acid 4.8317405874
MESH:D009369 Neoplasms sodium arsenite 4.8311559025
MESH:D009374 Neoplasms, Experimental resveratrol 9.028985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.0220056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4812497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009423 Nervous System Neoplasms Curcumin 5.5718462866
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1910525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.1912854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1718514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.1717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3417929310
MESH:D009634 Noonan Syndrome marker/mechanism 15273746 17703371 17603482 17603483
MESH:D009765 Obesity Curcumin 4.5519297423
MESH:D009765 Obesity pirinixic acid 4.5520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6916049721
MESH:D010024 Osteoporosis Curcumin 3.4318719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1917513867
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.8416624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 7.8418462866 19020741
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.8417306315 15276417
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6915580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.6917440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms gemcitabine 8.6918992248 11504793 16929163 18383843 17440100
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010538 Peritonitis Ozone 4.0716369182
MESH:D011014 Pneumonia Lipopolysaccharides 10.9012224865 11605937
MESH:D011014 Pneumonia Ozone 10.9018007984 18929643 18381685
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.6516679765
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.6518042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1319131511
MESH:D011471 Prostatic Neoplasms Curcumin 2.1312497104 18156803 18226269 11398177 18769126 10851300 15129424
MESH:D011471 Prostatic Neoplasms resveratrol 2.1317675339 16731767 17636462 17718901 17804756 15767336
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1316039940
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.4719168576
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5316325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.4619058328
MESH:D015427 Reperfusion Injury resveratrol 6.4616317513 16314181 15827377 17520802 17058453
MESH:D012120 Respiration Disorders Chlorine 5.1618579056
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9610666014 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6910835634
MESH:D012509 Sarcoma Curcumin 4.0618462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7118551238
MESH:D018805 Sepsis Curcumin 4.0218389075
MESH:D012878 Skin Neoplasms resveratrol 5.8515837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 5.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Curcumin 3.4416631530 19188055
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4216321402
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1015821434
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0419014326
MESH:D014062 Tongue Neoplasms resveratrol 4.1516227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.5416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.5416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.5412845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.5418593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.5416712894 16452187 17306315 11723127
MESH:D014565 Urogenital Neoplasms Curcumin 5.2018462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.7810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.7810091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.3717473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.3711813266
MESH:D014594 Uterine Neoplasms resveratrol 4.0717044934
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2417488730
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
REACT:18266 Axon guidance
REACT:20676 Cell junction organization
KEGG:05220 Chronic myeloid leukemia
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
REACT:604 Hemostasis
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:04630 Jak-STAT signaling pathway
KEGG:04670 Leukocyte transendothelial migration
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05211 Renal cell carcinoma
REACT:9417 Signaling by EGFR
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33986
    • Releated gene ID Related gene Name
    PA43AGTR1
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA444750Leukemia
    PA445103Neurofibromatosis 1
    PA445123Noonan Syndrome
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA10804imatinib
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02779 - Dodecane-Trimethylamine Surface-Active Agents;Detergents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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