AutismKB 2.0

Annotation Detail for HAMP


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Basic Information Top
Gene Symbol:HAMP ( HEPC,HFE2B,LEAP1,PLTR )
Gene Full Name: hepcidin antimicrobial peptide
Band: 19q13.12
Quick LinksEntrez ID:57817; OMIM: 606464; Uniprot ID:HEPC_HUMAN; ENSEMBL ID: ENSG00000105697; HGNC ID: 15598
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of ion transport and metabolism
H00211Hemochromatosis
Genetic disorders
Desease IDDesease Name
1781Rheumatoid arthritis
1848Embryoma
1856Obesity
1902Kidney failure
2053Colon cancer
2146Lupus erythematosus
2240Anemia
1882Malaria
Desease Name
Hemochromatosis
METABOLIC
No data
Desease Name
Hemochromatosis, type 2B
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HAMP mRNAaffects expression 21346803
D000079 Acetaldehyde Acetaldehyde inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 16737972
D000079 Acetaldehyde Acetaldehyde results in decreased expression of HAMP mRNAdecreases expression 16737972
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HAMP mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAMP mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HAMP mRNAdecreases expression 20106945
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HAMP mRNAaffects cotreatment|increases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HAMP mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of HAMP mRNAincreases expression 16239168
D003300 Copper Copper affects the expression of HAMP mRNAaffects expression 16614410
D003314 Corn Oil Corn Oil affects the expression of HAMP mRNAaffects expression 16360708
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of HAMP mRNAdecreases expression 19061943
D004052 Diethylnitrosamine Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 19061943
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAMP mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HAMP mRNAaffects cotreatment|increases expression 20360939
D004958 Estradiol Estradiol results in decreased expression of HAMP mRNAdecreases expression 20106945
D000431 Ethanol Acetaldehyde inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 16737972
D000431 Ethanol Ethanol results in decreased expression of HAMP mRNAdecreases expression 16737972
D000431 Ethanol Ethanol results in decreased expression of HAMP proteindecreases expression 16737972
D000431 Ethanol fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 16737972
D000431 Ethanol Ethanol results in decreased expression of HAMP mRNAdecreases expression 17207112
16737972
D000431 Ethanol HAMP protein inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]decreases reaction|increases expression 16737972
D000431 Ethanol HAMP protein inhibits the reaction [Ethanol results in increased expression of SLC40A1 protein]decreases reaction|increases expression 16737972
D000431 Ethanol Vitamin E inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 16737972
C010238 fomepizole fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 16737972
D007501 Iron HAMP protein results in decreased secretion of Irondecreases secretion 16460831
D007501 Iron [IL6 protein results in increased expression of HAMP protein] which results in decreased secretion of Irondecreases secretion|increases expression 16460831
D007501 Iron HAMP protein affects the metabolism of Ironaffects metabolic processing 17194590
16574947
D007501 Iron HAMP protein results in decreased secretion of Irondecreases secretion 16648237
D007501 Iron Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 19061943
D007501 Iron Iron results in increased expression of HAMP mRNAincreases expression 17255318
11113132
D007501 Iron Iron affects the expression of HAMP mRNAaffects expression 17116712
D007657 Ketone Bodies Ketone Bodies results in decreased expression of HAMP mRNAdecreases expression 16807920
D008070 Lipopolysaccharides BMP6 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]decreases reaction|increases expression 19252488
D008070 Lipopolysaccharides IL6 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]affects reaction|increases expression 17255318
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of HAMP mRNAincreases expression 19252488
17255318
16565419
16648237
11113132
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]affects reaction|increases expression 17255318
D019308 Palmitic Acid Palmitic Acid results in increased expression of HAMP mRNAincreases expression 17658692
D010269 Paraquat Paraquat results in increased expression of HAMP mRNAincreases expression 17275934
D010656 Phenylephrine Phenylephrine results in decreased expression of HAMP mRNAdecreases expression 18158353
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HAMP mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HAMP mRNAdecreases expression 15703262
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HAMP mRNAincreases expression 16267337
15703262
D014810 Vitamin E Vitamin E inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]decreases expression|decreases reaction 16737972
D015054 Zymosan EPO protein inhibits the reaction [Zymosan results in increased expression of HAMP mRNA]decreases reaction|increases expression 18664788
D015054 Zymosan Zymosan results in increased expression of HAMP mRNAincreases expression 18664788
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.0317676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 10.0318287403
MESH:D000138 Acidosis Ethanol 10.0311192467
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.9111850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.1711473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.776695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.7719389873
MESH:D000236 Adenoma Diethylnitrosamine 10.776695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.6216434500 19052882 17162532 19061943 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.6411874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1915451040 15451039
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.5216640825
MESH:D000544 Alzheimer Disease Copper 4.7417119284 16886094 16325427 16962711 16410023 16866297
MESH:D000544 Alzheimer Disease Iron 4.7416563566 16640825
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.2210694572
MESH:D000740 Anemia marker/mechanism 16434484 16627556
MESH:D000740 Anemia Iron 14.3316434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 14.3311748828
MESH:D000740 Anemia Zymosan 14.3318664788
MESH:D018798 Anemia, Iron-Deficiency Copper 10.0816614410
MESH:D018798 Anemia, Iron-Deficiency Iron 10.0817162259 17375513 16569441 17147795 17163184
MESH:D000756 Anemia, Sideroblastic Iron 4.6916910769
MESH:D000853 Anophthalmos Ethanol 4.6915513904
MESH:D001008 Anxiety Disorders Ethanol 3.9011141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001145 Arrhythmias, Cardiac Iron 8.9616604332
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.9617460149
MESH:D001169 Arthritis, Experimental Zymosan 4.0415142272 16872482 15188379 15944321 17659584
MESH:D001249 Asthma Acetaldehyde 3.639600491
MESH:D001260 Ataxia Telangiectasia Iron 5.3215336622
MESH:D050197 Atherosclerosis Iron 3.6316632123 16640825
MESH:D001321 Autistic Disorder Iron 2.8017352947
MESH:D001424 Bacterial Infections Iron 5.0616640825
MESH:D001656 Biliary Atresia marker/mechanism 16627878
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001919 Bradycardia Phenylephrine 4.4115306635
MESH:D001932 Brain Neoplasms Copper 4.4417079463
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3017474063 20146248
MESH:D001943 Breast Neoplasms Copper 2.3017079463 15986119
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3017474063
MESH:D001943 Breast Neoplasms Estradiol 2.3012948864 17261762 17289903 18497071 14630087 17018787 16675129 19861407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3020435547
MESH:D002056 Burns Ethanol 4.5216374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.5016192424 15673190 16097048 15721981 18705752 16227642 16124888 16011737 3786805 15700767 16050911 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.5016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6516705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.6518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.6519383236 18210153 18785209 17761372 20007298 17173139 19822196 16288022 18494052 20514400 20101231 16935385 16681979 19171122 20935162 20214788 19519916 17138121 21159647 17055752 3581430 17978847 16807293 19052882 16779866 19919837 20512989 19539802 20432363 18393292 19394651 3084413 18691550 18506893 19107877 16569478 20084675 19701751 16830150 19208518 20524982 10672840 16698587 16878318 18971187 20727157 18665156 18788625 11831363 16328049 18978308 16502159 18056438 19335982 16540662 17162532 10737359 19418558 17428255
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.6516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.6518788625 15763234 15289165
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0120419170
MESH:D006332 Cardiomegaly Copper 15.8017327471
MESH:D006332 Cardiomegaly Ethanol 15.8019332462
MESH:D006332 Cardiomegaly Phenylephrine 15.8011179087 17287366 11754973 16170337 17124262 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 15.8018670907 16120746 18850075
MESH:D009202 Cardiomyopathies Iron 3.9616640825
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 6.3510525098
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4216604332
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.666135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.667505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.6618566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002971 Cleft Lip Ethanol 3.5215513904
MESH:D002972 Cleft Palate Ethanol 5.7715513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7715668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Iron 2.8716640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 3.7510194807 19302082 11873399 15451039 15513904 15451040 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7519769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8918551238
MESH:D003920 Diabetes Mellitus Iron 4.3416640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3216506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0020387270
MESH:D003924 Diabetes Mellitus, Type 2 Iron 7.0016506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3019279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.6021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.603732212 15968718 9327722 21278145 7120509 19085960 3786805 10915739 15027814 2869522 7179309 16227642 15998439 7440962 11566570 4309450 19336974 17522070 6623471 16177239 6884620 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.6019107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.6011566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:C538011 Eales disease Vitamin E 4.579068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7012711302 11000095
MESH:D004487 Edema Zymosan 6.707907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.9018566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9110568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2617637181 15328337 15821434
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4916530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.4916704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.8712795759 16045604 15959796 19224547 12631006 61145 16239168 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 17.8720387270 21071580
MESH:D005234 Fatty Liver Ethanol 17.8719236843 16409862 18620774
MESH:D005234 Fatty Liver Iron 17.8716640825
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1716946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005334 Fever Lipopolysaccharides 3.909205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1620067830
MESH:D005621 Friedreich Ataxia Iron 5.3016604332 16640825
MESH:D005756 Gastritis Ethanol 4.5615046732
MESH:D005911 Gliosis Paraquat 5.0411124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7110048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.7116080930
MESH:D006432 Hemochromatosis marker/mechanism 19252486 16627556 17255318
MESH:D006432 Hemochromatosis Iron 4.3917053826 16574947 17255318 16640825 17236123 16604332
OMIM:602390 HEMOCHROMATOSIS, TYPE 2A marker/mechanism
OMIM:613313 HEMOCHROMATOSIS, TYPE 2B marker/mechanism
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006486 Hemosiderosis Iron 5.0916604332
MESH:D006505 Hepatitis Carbon Tetrachloride 9.2319900420 19110552
MESH:D006505 Hepatitis Zymosan 9.2319110552
MESH:D006521 Hepatitis, Chronic Copper 5.1517338147
MESH:D006525 Hepatitis, Viral, Human Iron 5.3416640825
MESH:D006527 Hepatolenticular Degeneration Copper 11.0417109627 17182432 16607473 17276780 19888908
MESH:D006527 Hepatolenticular Degeneration Iron 11.0417182432
MESH:D006529 Hepatomegaly Iron 8.3116890145
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D015658 HIV Infections Iron 3.6016597321
MESH:D019584 Hot Flashes Estradiol 9.6217088409
MESH:D019584 Hot Flashes Vitamin E 9.6214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9216354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Ethanol 3.6118783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.6811484837
MESH:D006973 Hypertension Phenylephrine 5.148949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D006984 Hypertrophy Phenylephrine 4.4318502941 12791704
MESH:D007006 Hypogonadism Iron 4.3116640825
MESH:D007037 Hypothyroidism Iron 4.9516640825
MESH:D007248 Infertility, Male Paraquat 3.164850670
MESH:D007249 Inflammation Diethylnitrosamine 11.4618785209
MESH:D007249 Inflammation Lipopolysaccharides 11.4617237260 17255318 12878042 9205823 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.4612878042 12200463
MESH:D007249 Inflammation Zymosan 11.468014878 11289658
MESH:D007251 Influenza, Human Vitamin E 4.0916624496
MESH:D007333 Insulin Resistance Estradiol 2.8816627594 16393666
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4710783313
MESH:D019189 Iron Metabolism Disorders Iron 11.1817163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 11.1817255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.7117553498
MESH:D007569 Jaw Abnormalities Ethanol 9.7215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7216580747
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 9.7815369732
MESH:D007674 Kidney Diseases Estradiol 9.7815618244
MESH:D007674 Kidney Diseases Vitamin E 9.7812488133
MESH:D007676 Kidney Failure, Chronic marker/mechanism 16929540
MESH:D007676 Kidney Failure, Chronic Copper 4.7816518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.0016705839
MESH:D007680 Kidney Neoplasms Estradiol 7.0015610895
MESH:D007859 Learning Disorders Copper 9.6217134702
MESH:D007859 Learning Disorders Ethanol 9.6215451040
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.9116766008
MESH:D007970 Leukopenia Lipopolysaccharides 4.5715821434
MESH:D020961 Lewy Body Disease Iron 5.3016563566
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7217676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 15.2311408273 16239168 16943688 11903743 16221502 21278145 17174718 17334410 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 15.2318522880 19638242 18665156 18407596 20032147
MESH:D008103 Liver Cirrhosis Ethanol 15.2315289165
MESH:D008103 Liver Cirrhosis Iron 15.2316640825
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9718295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.5315931870 15123356 14748882 18420326 18472094 12445418 15925388 14724832 18277467 16027843 17823541 18395095 14716496 18279442 15673190 12609069 17708605 16033810 12649538 12586293 17481882 17900296 17869086 18263696 18472332 15650968 15338365 17631135 16136751 17640975 17805973 18418968 14620537 11481614 12632514 16116963 12898905 14716833 18006644 15876570 17557913 13678700 18054572 18429990 12389079 12667390 14512876 16011737 15370692 17976157 18210741 15996030 16248980 15893842 16638106 12632512 16015684 18166357 17922224 12958196 12666154 15959796 17761835 17565644 12546737 15057751 17698563 10355542 15730626 15052691 18251166 18156304 15818738 16097048 18339082 16192424 18187930 20821823 18412020 18205269 15362042 17525996 17766677 12445421 18395914 18317297 17714472 12741479 18376398 17944888 18705752 18481824 17721639
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.5318166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.5316169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9615720792 17285989 16246199 15830285 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9617034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 11.0617207112 17347304
MESH:D008108 Liver Diseases, Alcoholic Iron 11.0617207112 16737972
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5716899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 25.137678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 25.1320195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 25.1319389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 25.1319294768
MESH:D008113 Liver Neoplasms Copper 25.1320302851
MESH:D008113 Liver Neoplasms Diethylnitrosamine 25.1319294768 19638242 19255062 18754104 2422723 12771043 19073162 20137499 20492335 19690152 19833225 20101389 18644402 12112319 19090486 18977376 19850985 18648771 20118626 19254457 21071580 21278145 10737359 19426721 21167192 15175105 19256749 19499222 20583210 19812893 19642983 20452335 20501860 20405173 18978307 21047994 9163691 16942905 15885732 20434301 19551842 2862719 19996281 19427195
MESH:D008113 Liver Neoplasms Iron 25.1316640825 20302851
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.1316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.782876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.7818164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.7815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.7818544905 18282651 18079962 18164116 19539802 19126423 19009564 21159647 16267830 19519916 2563599 3124819 19004024 18253720 18775883 17854601 16842330 17942915 9362446 17174075 18093689 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.7812151625
MESH:D008171 Lung Diseases Vitamin E 3.0916863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.8821114838
MESH:D008175 Lung Neoplasms Acetaldehyde 8.3617372256
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.3617053015 20464547 18520028 18569708 6695378 18816296 20135361 20064080 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3620970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Iron 8.3616640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3619555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.3611062179
MESH:D008268 Macular Degeneration Iron 3.9116640825
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4811807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D008569 Memory Disorders Ethanol 4.0615451040 18411066
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.7517109627 17268249
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009102 Multiple Organ Failure Zymosan 5.0815259001 10479408 15213630 15241586 17724436 18160304 15834315 12130978 12879239 10890648
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.5417086897
MESH:D009181 Mycoses Iron 5.3416640825
MESH:D017202 Myocardial Ischemia Iron 8.8216604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4016810080
MESH:D015428 Myocardial Reperfusion Injury Iron 8.4016604332
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.529029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1111141357
MESH:D009389 Neovascularization, Pathologic Copper 9.9117308104
MESH:D009389 Neovascularization, Pathologic Estradiol 9.9117289903
MESH:D009404 Nephrotic Syndrome Iron 4.4017178036
MESH:D009410 Nerve Degeneration Paraquat 3.6116893418
MESH:D009421 Nervous System Malformations Estradiol 9.0416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0414600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3320387270
MESH:D019636 Neurodegenerative Diseases Iron 8.3317296847 16604332
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3216049721
MESH:D010003 Osteoarthritis Iron 3.8916640825
MESH:D010024 Osteoporosis Iron 3.7816640825 16648989
MESH:D010051 Ovarian Neoplasms Estradiol 2.1819401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2816540662
MESH:D010190 Pancreatic Neoplasms Ethanol 5.2812384795
MESH:D010212 Papilloma Iron 4.3512065085
MESH:D020447 Parasomnias Iron 5.8917352947
MESH:D010300 Parkinson Disease Iron 5.5416563566 16640825
MESH:D010300 Parkinson Disease Paraquat 5.5415451049 16510128 11445065 15824117 12911755 16140633 11181820 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.3016190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010538 Peritonitis Zymosan 4.7517371808 19088179 18977430 17826846 11985352 19641140 14761945 18557954 15259001 15979727 18760300
MESH:D010900 Pituitary Diseases Iron 5.5416604332
MESH:D011014 Pneumonia Lipopolysaccharides 10.6912224865 11605937
MESH:D011014 Pneumonia Paraquat 10.6912504350
MESH:D011041 Poisoning Iron 4.1716604332
MESH:D017119 Porphyria Cutanea Tarda Iron 10.6016640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.6018163543
MESH:D011230 Precancerous Conditions Corn Oil 9.2414668109
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.242563599
MESH:D011225 Pre-Eclampsia Iron 4.3216640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1317292933
MESH:D011471 Prostatic Neoplasms Copper 2.1317308104 17079463
MESH:D011471 Prostatic Neoplasms Estradiol 2.1316740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1315084515
MESH:D011528 Protozoan Infections Iron 5.8916640825
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8616324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.7811700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6510835634
MESH:D012135 Respiratory Sounds Paraquat 3.9311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012148 Restless Legs Syndrome Iron 4.4516930377
MESH:D012162 Retinal Degeneration Paraquat 3.7716458197
MESH:D012220 Rhinitis Acetaldehyde 4.6317050345
MESH:D012559 Schizophrenia Copper 3.0716842975
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8118551238
MESH:D012640 Seizures Ethanol 5.819754883
MESH:D018805 Sepsis Zymosan 4.5411441115
MESH:D012852 Sinusitis Phenylephrine 4.577327846
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1519755658 10029692
MESH:D012878 Skin Neoplasms Iron 9.1512065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.322093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3218456281
MESH:D013274 Stomach Neoplasms Ethanol 3.3218456281
MESH:D013276 Stomach Ulcer Ethanol 3.419211565 17189318 9562338 16755016 17918041 11906479
MESH:D020521 Stroke Vitamin E 3.4116517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.149754883
MESH:D013398 Sudden Infant Death Iron 5.3216640825
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0515821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.887505956
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D014376 Tuberculosis Iron 4.0116597321
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.8016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.8017053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1910091137
MESH:D014605 Uveitis Zymosan 5.2711006244
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29182
    • Releated gene ID Related gene Name
    PA198IL6
    Releated disease ID Related disease Name
    PA444405Hemochromatosis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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