AutismKB 2.0

Annotation Detail for PTPN12


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Basic Information Top
Gene Symbol:PTPN12 ( PTP-PEST,PTPG1 )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 12
Band: 7q11.23
Quick LinksEntrez ID:5782; OMIM: 600079; Uniprot ID:PTN12_HUMAN; ENSEMBL ID: ENSG00000127947; HGNC ID: 9645
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1808Eye disease
1831Prostate cancer
Desease Name
Graves ophthalmology Graves' disease
VISION
No data
Desease Name
Colon cancer
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PTPN12 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPN12 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPN12 mRNAdecreases expression 20018196
19150397
D002118 Calcium Calcium affects the expression of PTPN12 mRNAaffects expression 15913539
D016572 Cyclosporine Cyclosporine results in increased expression of PTPN12 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of PTPN12 mRNAincreases expression 18042831
D005419 Flavonoids Flavonoids results in increased expression of PTPN12 mRNAincreases expression 18035473
D007213 Indomethacin Indomethacin results in decreased expression of PTPN12 mRNAdecreases expression 16984733
D009151 Mustard Gas Mustard Gas results in increased expression of PTPN12 mRNAincreases expression 15674844
C001478 N(6)-(delta(2)-isopentenyl)adenine N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PTPN12 mRNAincreases expression 16129123
C041786 palm oil palm oil results in increased expression of PTPN12 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of PTPN12 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Indomethacin 2.8116537180
MESH:D000236 Adenoma Indomethacin 3.5111497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D016301 Alveolar Bone Loss Indomethacin 5.5517225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7217627676 15579461
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.9810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.0110388637
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D018771 Arthralgia Indomethacin 5.342160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8411248219
MESH:D001249 Asthma Mustard Gas 2.7410378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001477 Bartter Syndrome Indomethacin 5.1210684365
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001929 Brain Edema Indomethacin 5.2011481608
MESH:D002545 Brain Ischemia Indomethacin 4.5712524144
MESH:D001943 Breast Neoplasms Dietary Fats 2.3920435547
MESH:D001943 Breast Neoplasms Indomethacin 2.3917401462
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D002056 Burns Indomethacin 4.8410459503
MESH:D002100 Cachexia Indomethacin 5.1615141370 15625704 11239499 16537180
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.123084413
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 3.1216391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.8811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.5118791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4217341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8715482327 12636206
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8012371664
MESH:D002764 Cholecystitis Indomethacin 5.3411181007
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D003110 Colonic Neoplasms Indomethacin 2.6115637740 15936596 15963497 15625704 11260862 15786552
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 18059344 11197048 17054584
MESH:D018352 Coronavirus Infections Indomethacin 5.8917302372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003967 Diarrhea Indomethacin 3.927237001 7907874
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6114550746 19923254 19416960 12958197 12705907 19370779 10774834 12594235 11743745 11834606 16781746 16393943 18713872 19085960 12153990 10915739 14725611 16177239 11529661 19739265 19420014 14986274 12540782 16081117 12392966 17562736 18071297 17522070 11739529 19164858 10663392 2444490 15619225 16485898 11461765 11287661 16227642 17906064 15968718 16109766 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.3018446180 18043480 16326151 16133044 12774134 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 4.2617329845 11595415 17351913 16699067 11991626 10671773 17151854 17202747 11535926 11595431 17045617
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Indomethacin 12.2316100529 8273558 7907874 8985016 19703484 7990266 10653021
MESH:D004487 Edema Mustard Gas 12.2311428631 9260866 11428647 11402378
MESH:D004487 Edema pirinixic acid 12.2312083418
MESH:D004715 Endometriosis Indomethacin 4.2515652904
MESH:D019446 Endotoxemia Indomethacin 4.6518509659
MESH:D004751 Enteritis Indomethacin 4.9210567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.1217980183
MESH:D004802 Eosinophilia Indomethacin 4.1911298111
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7320426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.7311005569
MESH:D005234 Fatty Liver Cyclosporine 13.7119224547
MESH:D005234 Fatty Liver Dietary Fats 13.7117967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 13.7119236843 20131406
MESH:D005334 Fever Indomethacin 4.2217627676 11852909 10431976
MESH:D005354 Fibrosarcoma Indomethacin 5.0510962813
MESH:D005355 Fibrosis Cyclosporine 15.7112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.7118296743
MESH:D005355 Fibrosis Indomethacin 15.7117994277
MESH:D005499 Folliculitis Indomethacin 5.3411298111
MESH:D005756 Gastritis Acetaminophen 11.7416983495
MESH:D005756 Gastritis Indomethacin 11.7415046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Indomethacin 3.6312870263
MESH:D005910 Glioma Indomethacin 3.2616487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.3711849393
MESH:D006073 Gout Indomethacin 5.5111248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.8115482327
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.6815633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.8115135802
MESH:D006529 Hepatomegaly pirinixic acid 3.1316221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 8.1216870215
MESH:D006930 Hyperalgesia Indomethacin 8.1212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.8917883296
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006940 Hyperemia Indomethacin 5.1612524144
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 9.7421332399
MESH:D006949 Hyperlipidemias Indomethacin 9.7417546600
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007077 Ileal Diseases Indomethacin 5.2010574470 18306037
MESH:D007079 Ileitis Indomethacin 5.5110647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.5516133044
MESH:D007249 Inflammation Dietary Fats 12.4920412841
MESH:D007249 Inflammation Flavonoids 12.4917296493
MESH:D007249 Inflammation Indomethacin 12.4912568917 7812673 3291741
MESH:D007249 Inflammation Mustard Gas 12.499260866 11402378 9357497 11428647 8975870 16001271 11428620 11428631 17524151
MESH:D007333 Insulin Resistance Dietary Fats 7.4811836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007410 Intestinal Diseases Indomethacin 4.4610210152 15831440 15610444 11686837 17994277 17329856 18236018 11713966 11855677
MESH:D019586 Intracranial Hypertension Indomethacin 5.5515241188
MESH:D007579 Jejunal Diseases Indomethacin 5.2018306037 16133968 10574470
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.428314463 18776723 10903974
MESH:D007674 Kidney Diseases Indomethacin 10.4217190690
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.2216316344
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9911703811 12228301 10320625
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.0010785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6518360721
MESH:D007964 Leukocytosis Indomethacin 5.5516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.8917980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.8911479899
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.5818194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5815474484
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 16611625 12587719 19784758 16610002 12969438 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8520007298 15890375 16377806
MESH:D008171 Lung Diseases Mustard Gas 3.5218702808 18161513
MESH:D008175 Lung Neoplasms Indomethacin 2.8511497255 11053908 16537180
MESH:D008175 Lung Neoplasms Mustard Gas 2.858781369 3148597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D008881 Migraine Disorders Indomethacin 3.7511903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.0712636206
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2011239499 16537180 11053908
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.2710663608 15625704
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7118514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.7112349958
MESH:D009503 Neutropenia Mustard Gas 4.0916761898 7688884
MESH:D009765 Obesity Dietary Fats 4.5219632207 11836018 18674790 17217161 20518802 21332399 20132043 16723640 18457598
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.346374098
MESH:D010003 Osteoarthritis Indomethacin 3.737009135
MESH:D010024 Osteoporosis Calcium 3.8417882678
MESH:D010146 Pain Acetaminophen 7.1016870215
MESH:D010146 Pain Indomethacin 7.1017627676 13679232 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.8512538197 18702446
MESH:D010195 Pancreatitis Indomethacin 4.0417883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.8916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.2212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.8911903285
MESH:D010437 Peptic Ulcer Indomethacin 5.3011148446
MESH:D010518 Periodontitis Indomethacin 5.0917225004
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D047928 Premature Birth Indomethacin 5.2717000239
MESH:D011507 Proteinuria Indomethacin 4.2811849393
MESH:D011537 Pruritus Mustard Gas 4.2518058305
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9617894541 17620002 17266442 17720292 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012871 Skin Diseases Mustard Gas 2.7412880345 16961503 15451306
MESH:D013272 Stomach Diseases Indomethacin 4.5715038085 18209964 15472012 16184426 17207306 18545984 16280098 10215738 17638125 10192188 16113693 17160473 10486359
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 3.6916631530 11145282 11595431 11729361 17977527 17657623 10878458 16150113 16397915 14567935 18543354 12467913 17135157 17654042 17895592 16252198 18209962 12500499 10750652 18193104 17918041 12498302 15138204 18237397 12077510 15104355 17627676 15255614 10423059 18726076 18431645 18299717 11906479 18087811 16934674 16169175 1323529 11595415 16755016 11523592 18181030 12787963
MESH:D013964 Thyroid Neoplasms Indomethacin 3.6711352223 14736730 18791128
MESH:D014456 Ulcer Indomethacin 5.0517380554 10574470
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014839 Vomiting Indomethacin 4.9211897121
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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