AutismKB 2.0

Annotation Detail for PTPN13


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Basic Information Top
Gene Symbol:PTPN13 ( DKFZp686J1497,FAP-1,PNP1,PTP-BAS,PTP-BL,PTP1E,PTPL1,PTPLE )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Band: 4q21.3
Quick LinksEntrez ID:5783; OMIM: 600267; Uniprot ID:PTN13_HUMAN; ENSEMBL ID: ENSG00000163629; HGNC ID: 9646
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
200173Ephrin B reverse signaling
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1944Breast cancer
1964Primary biliary cirrhosis
2237Neoplasm metastasis
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol PTPN13 protein results in decreased susceptibility to 1-UFT protocoldecreases response to substance 16734730
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPN13 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PTPN13 mRNAdecreases expression 20064835
C110904 capecitabine PTPN13 protein results in decreased susceptibility to capecitabinedecreases response to substance 16734730
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTPN13 mRNAaffects expression 17484886
D003474 Curcumin Curcumin results in decreased expression of PTPN13 mRNAdecreases expression 15713895
C025034 doxifluridine PTPN13 protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
D004317 Doxorubicin Doxorubicin results in increased expression of PTPN13 mRNAincreases expression 16001973
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTPN13 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of PTPN13 mRNAdecreases expression 16202921
D004958 Estradiol Estradiol results in increased expression of PTPN13 mRNAincreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of PTPN13 mRNAdecreases expression 14664709
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTPN13 mRNAaffects expression 17555576
C071834 glycidamide glycidamide results in decreased expression of PTPN13 mRNAdecreases expression 17822822
C051890 irinotecan irinotecan metabolite results in decreased expression of PTPN13 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of PTPN13 mRNAdecreases expression 15956246
C025430 LY 117018 LY 117018 results in increased expression of PTPN13 mRNAincreases expression 15876410
D017239 Paclitaxel PTPN13 protein results in increased susceptibility to Paclitaxelincreases response to substance 16734730
D020849 Raloxifene Raloxifene results in increased expression of PTPN13 mRNAincreases expression 15876410
C009166 retinol acetate retinol acetate results in increased expression of PTPN13 mRNAincreases expression 16772331
C079198 S 1 (combination) PTPN13 protein results in decreased susceptibility to S 1 (combination)decreases response to substance 16734730
D013629 Tamoxifen Tamoxifen affects the expression of PTPN13 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTPN13 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTPN13 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PTPN13 mRNAdecreases expression 17337447
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.0320127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 10.0317418594
MESH:D000230 Adenocarcinoma Estradiol 10.0311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.0314692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D000419 Albuminuria Doxorubicin 11.2521441931
MESH:D000419 Albuminuria Raloxifene 11.2517308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0317887948
MESH:D000544 Alzheimer Disease Curcumin 4.3915590663
MESH:D000544 Alzheimer Disease Raloxifene 4.3915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 5.5716807698
MESH:D001172 Arthritis, Rheumatoid LY 117018 5.5717907171
MESH:D050197 Atherosclerosis Curcumin 3.2818704882
MESH:D001327 Autoimmune Diseases Curcumin 4.4319761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6414601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.5015867366
MESH:D001930 Brain Injuries Raloxifene 4.4116580743
MESH:D002545 Brain Ischemia Curcumin 4.2716770732
MESH:D001932 Brain Neoplasms Curcumin 8.7617596214
MESH:D001932 Brain Neoplasms Doxorubicin 8.7617150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.7817474063 20146248
MESH:D001943 Breast Neoplasms capecitabine 5.7818473752 12972520
MESH:D001943 Breast Neoplasms Curcumin 5.7818462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Doxorubicin 5.7815136595 18382427 15993339 16096432 16322301 11325840 15939500 17426702 16264153 17369602 16826403 16115903 18695136 15567936 15692762 18234424 15634643 18628466 16595493 17983394 19526202 15994142 15668708 16935488
MESH:D001943 Breast Neoplasms Estradiol 5.7812948864 19861407 16675129 17261762 17289903 14630087 18497071 17018787
MESH:D001943 Breast Neoplasms Paclitaxel 5.7816115903 16273361 11325840 18223236 18323546 18234424 16244791 15136595
MESH:D001943 Breast Neoplasms Raloxifene 5.7816912660 15572757 17595753 15758505 16837676 17242785 15775269 17261762 17952589 17440819 17893378 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 5.7818855134 18351453 17049068 19189210 19289846 19200415 20065188 19115204 18997820 19221464 19487384 19011961 18821012 20135344 17242785 17893378 19103187 19189212 16818667 20859285 16873071 17261762 20005174 19288272 16273361 21152245 21138602 11161223 18425577 20544844 19066611 19084267 19142967 19155303 19410462 20390343 19244106 15565566 18984771 18815881 18629630 15668708 19059307 17440819 16202921
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.7820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7216011737 3786805 16097048 15721981 16124888 16227642 16050911 10355542 16192424 15700767 18705752 15673190
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7516051944
MESH:D002277 Carcinoma Curcumin 8.1018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7818788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.7817876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7816924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.7816313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 6.0918414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 6.0918347146 18212800
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.131485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.7420419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.7418462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.746189445
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 10.7415984520
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.3017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.3017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4817308081 16269455 16242529 16731534 17329180 16952015 16455267 17351982 15476868 17131338 17382496 17928571 16612575 16651473 17974986 15811867 17924179 16364871 17007740 17519947 15505089 16109756 15792986 18627295 16278810
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4015775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8217110522 17681005 17333356 16105132 15861022 11677210 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 8697196 15668235 12621046 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.5515800139
MESH:D003092 Colitis Curcumin 4.1118200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.4918809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0219359593 16340194
MESH:D003110 Colonic Neoplasms irinotecan 4.0217287894 17725105
MESH:D015179 Colorectal Neoplasms capecitabine 4.8718448328 18473752
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8718802399 18259882
MESH:D015179 Colorectal Neoplasms irinotecan 4.8717159606 18509181 16391804 16303861 18259882 17454858 15273666
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.8718802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.8318497527
MESH:D003329 Coronary Vasospasm capecitabine 5.7417465463
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1017474826
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3518403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Curcumin 20.9618204486
MESH:D003928 Diabetic Nephropathies Estradiol 20.9619279558
MESH:D003928 Diabetic Nephropathies Raloxifene 20.9617308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 20.9619279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.136884620 3732212 10092053 15968718 15027814 19085960 7179309 16177239 21278145 9327722 19336974 17522070 2869522 3786805 11566570 15998439 4309450 10915739 6623471 7440962 16227642 7120509
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.1317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1320420201
MESH:D004362 Drug Toxicity Doxorubicin 7.9418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9411462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9817351913
MESH:D004487 Edema Raloxifene 6.6515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.9815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.9819031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.2217359293
MESH:D016889 Endometrial Neoplasms Estradiol 12.2211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.2216202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.969294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1018037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.5916481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.0217595544 19224547 15959796 16239168 61145 12631006 16045604 12795759
MESH:D005234 Fatty Liver Curcumin 24.0219297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.0215345470
MESH:D005234 Fatty Liver Raloxifene 24.0217473493
MESH:D005234 Fatty Liver Tamoxifen 24.0214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.2419069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.2419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.4618705752
MESH:D005355 Fibrosis Curcumin 14.4618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.4620067830
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.7019093184
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6318462866
MESH:D005909 Glioblastoma Curcumin 7.2717596214
MESH:D005909 Glioblastoma Doxorubicin 7.2717150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 12.9718829502 18462866
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.9715692506
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 12.9718607998 15984520
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3311294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 7.6916879835 16495754 18674790 18006777 16330681 17875725 16707910 14766674 17888722 16244372 12587719 16144979 16244371
MESH:D006331 Heart Diseases Raloxifene 7.6911110106
MESH:D006333 Heart Failure Doxorubicin 3.3017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8415692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8312621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9817701891
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.3517606976 15147373 18501091
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 8697196 16354765 15340226 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006937 Hypercholesterolemia Curcumin 3.9918704882
MESH:D006973 Hypertension Raloxifene 5.1415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4417937319
MESH:D007249 Inflammation Curcumin 8.1416956363 17151092 18403477
MESH:D007249 Inflammation Tamoxifen 8.1419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1818200517 18596194
MESH:D007333 Insulin Resistance Estradiol 2.9216627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 4.1610783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases Doxorubicin 6.0715699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 6.0715618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0916707910
MESH:D007680 Kidney Neoplasms Estradiol 7.2015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.2018625569
MESH:D007889 Leiomyoma Curcumin 10.9418555241
MESH:D007889 Leiomyoma Raloxifene 10.9416973256
MESH:D007938 Leukemia Curcumin 3.2118462866
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1016085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.1416106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.7016106398
MESH:D008064 Lipidoses Tamoxifen 3.1117567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.7617353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7717157831 16943688 17174718 16221502 17334410 11408273 21278145 16239168 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.6418418968 12898905 12667390 16015684 17525996 17805973 11481614 15925388 15123356 18210741 17900296 17557913 15818738 15338365 18376398 12389079 16097048 17565644 12632512 14716496 18205269 17922224 13678700 18472332 18166357 17869086 18187930 17976157 17721639 16638106 12958196 12445418 18251166 17481882 10355542 16248980 15996030 16136751 18279442 18263696 17766677 18472094 15362042 17823541 17631135 14512876 16192424 18395914 20821823 18412020 15052691 16011737 17761835 15650968 12586293 12546737 18156304 18317297 18429990 15370692 18395095 16116963 12609069 15959796 12741479 14620537 18339082 15893842 18420326 17698563 15057751 12632514 18705752 14748882 16027843 18006644 14716833 12649538 17714472 18277467 12445421 15730626 17640975 18054572 17944888 15673190 16033810 12666154 17708605 15931870 18481824 14724832 15876570
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.6418006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.6416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.6414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.6418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2016246199 15830285 15720792 16964402 17285989
MESH:D008107 Liver Diseases Curcumin 4.2016956363
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6314706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.4720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.4719294768
MESH:D008113 Liver Neoplasms Tamoxifen 10.4716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.6012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.6016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5120135361 20064080 17053015 20464547 18520028 18816296 6695378 18569708 20869020
MESH:D008175 Lung Neoplasms Curcumin 6.5119359593 16243823 18462866
MESH:D008175 Lung Neoplasms Doxorubicin 6.5117418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 6.5118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5111884234 19555203
MESH:D008223 Lymphoma Curcumin 7.6318462866
MESH:D008223 Lymphoma Doxorubicin 7.6316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.7717654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.7714749477
MESH:D016399 Lymphoma, T-Cell Curcumin 11.3516173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.3515621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.7415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.7416891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.7416827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.4619453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.4619453300
MESH:D008545 Melanoma Curcumin 7.2618462866 17885582
MESH:D008545 Melanoma Doxorubicin 7.2616827129
MESH:D008545 Melanoma Paclitaxel 7.2612040289 12025231 16342250
MESH:D008545 Melanoma Tamoxifen 7.2612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008569 Memory Disorders Curcumin 4.0917263510
MESH:D008654 Mesothelioma Doxorubicin 3.0317638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4415792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D052016 Mucositis Doxorubicin 12.2117415656
MESH:D052016 Mucositis irinotecan 12.2117159606
MESH:D009101 Multiple Myeloma Curcumin 12.0019372569
MESH:D009101 Multiple Myeloma Paclitaxel 12.0014749477
MESH:D009101 Multiple Myeloma Raloxifene 12.0016497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8617962980
MESH:D009203 Myocardial Infarction Doxorubicin 2.9215857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2316810080
MESH:D009232 Myxoma Raloxifene 5.5016343187
MESH:D009361 Neoplasm Invasiveness Curcumin 4.3118495463
MESH:D009362 Neoplasm Metastasis capecitabine 17.7012972520
MESH:D009362 Neoplasm Metastasis Doxorubicin 17.7018259882
MESH:D009362 Neoplasm Metastasis irinotecan 17.7018259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 17.7015867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 17.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4411141357
MESH:D009369 Neoplasms capecitabine 5.4416374040
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.6612497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.6619189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009401 Nephrosis Doxorubicin 4.7016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9416889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 9.2516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2514600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5718462866
MESH:D009447 Neuroblastoma Doxorubicin 7.0415555623
MESH:D009447 Neuroblastoma irinotecan 7.048761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.678761367
MESH:D009765 Obesity Curcumin 2.7319297423
MESH:D010014 Osteolysis Paclitaxel 4.9215867366
MESH:D010024 Osteoporosis Curcumin 7.2818719352
MESH:D010024 Osteoporosis Raloxifene 7.2817882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal LY 117018 10.7317907171 17638036
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.7317823083 15758505 17893378 15579764
MESH:D012516 Osteosarcoma Doxorubicin 4.0615930896
MESH:D010051 Ovarian Neoplasms Curcumin 7.8919020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 7.8919401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.8911161223
MESH:D010190 Pancreatic Neoplasms Curcumin 2.9119196508 19401701 17440100
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.0915129424 10851300 12497104 18769126 11398177 18226269 18156803
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0916729912 16868541 16888761 15897917 15749863 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0917136230 16729912 17172428 16356831
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0916536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D011656 Pulmonary Emphysema Curcumin 4.4719168576
MESH:D011693 Purpura Raloxifene 5.5015770314
MESH:D051437 Renal Insufficiency Doxorubicin 4.1617922066
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9618379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012509 Sarcoma Curcumin 9.3718462866
MESH:D012509 Sarcoma Doxorubicin 9.3715675481 17203757 17710206 16767912 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7317846226
MESH:D018805 Sepsis Curcumin 4.0218389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2510029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 9.2515692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5015625365 16767912 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 11.3716709447
MESH:D013088 Spermatocele Tamoxifen 11.3716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.792093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 4.7915723263
MESH:D013274 Stomach Neoplasms Paclitaxel 4.7918396642 18506536
MESH:D013274 Stomach Neoplasms S 1 (combination) 4.7916557585 18506536 18553229
MESH:D013276 Stomach Ulcer Curcumin 3.4416631530 19188055
MESH:D020521 Stroke Raloxifene 3.7716837676
MESH:D024801 Tauopathies Paclitaxel 4.7516930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3217909728 16010429
MESH:D013978 Tibial Fractures Estradiol 13.5319048282
MESH:D013978 Tibial Fractures Raloxifene 13.5319048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.5517053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.5518593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.5517653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.5517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.5516712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 5.2018462866
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1516837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1617678736 17638931 17334414 16364871
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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