AutismKB 2.0

Annotation Detail for CYP4F11


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Basic Information Top
Gene Symbol:CYP4F11 ( CYPIVF11 )
Gene Full Name: cytochrome P450, family 4, subfamily F, polypeptide 11
Band: 19p13.12
Quick LinksEntrez ID:57834; OMIM: 611517; Uniprot ID:CP4FB_HUMAN; ENSEMBL ID: ENSG00000171903; HGNC ID: 13265
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Biological oxidations
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Pathway IDPathway Name
500203Miscellaneous substrates
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CYP4F11 mRNAdecreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CYP4F11 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of CYP4F11 mRNAincreases expression 20106945
C071834 glycidamide glycidamide results in increased expression of CYP4F11 mRNAincreases expression 17822822
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of CYP4F11 mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CYP4F11 mRNA]decreases expression|increases reaction 18467677
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5911798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5920127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0416206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9815073043 14691202 15553829 16217749 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5015213294
MESH:D004487 Edema perfluorooctanoic acid 3.9512083418 17259670
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D005234 Fatty Liver arsenic trioxide 9.0215073043
MESH:D005234 Fatty Liver Cyclosporine 9.0219224547
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006529 Hepatomegaly perfluorooctanoic acid 4.583609246
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.1412083418
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007249 Inflammation perfluorooctanoic acid 3.2112083418
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.528314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D007938 Leukemia arsenic trioxide 2.9815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1817050201 16968895 19850784 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4317869043 16112521 12679006 17712046 16330433 12018890 15336539 12712474 17217047 16823087 11161223 9834237 16966277 19642359 15748426 11468182 16331271 15213294 19225113 17107899 15622746 19075265 16891316 17649720 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.778812269
MESH:D008113 Liver Neoplasms arsenic trioxide 8.2014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.2021137059 20195826
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 8.2018709148 14757943
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4919825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4918520028 17053015 6695378 20464547 20135361 18569708 18816296 20064080 20869020
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3519417148 11468182 19549372 15949261 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3216882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3310525206
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.449802331
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4919769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6215580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.9317132714
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.432093021 20155912
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4211780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4217053015
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
REACT:13433 Biological oxidations
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27120
    • No data
    Releated disease ID Related disease Name
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA451627testosterone
    PA449957ibuprofen
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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