Annotation Detail for PTPN14
Basic Information Top
| Gene Symbol: | PTPN14 ( MGC126803,PEZ,PTP36 ) |
|---|---|
| Gene Full Name: | protein tyrosine phosphatase, non-receptor type 14 |
| Band: | 1q32.3-q41 |
| Quick Links | Entrez ID:5784; OMIM: 603155; Uniprot ID:PTN14_HUMAN; ENSEMBL ID: ENSG00000152104; HGNC ID: 9647 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of PTPN14 mRNA | affects expression | 17484886 |
| D010126 | Ozone | Ozone results in increased expression of PTPN14 mRNA | increases expression | 17095637 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PTPN14 mRNA | affects binding|decreases expression|increases activity | 19710929 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTPN14 mRNA | affects binding|increases activity|increases expression | 19710929 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 3.64 | 18653653 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 4.22 | 16434500 | |
| MESH:D000544 | Alzheimer Disease | Ozone | 2.51 | 15513908 | |
| MESH:D001172 | Arthritis, Rheumatoid | Ozone | 2.63 | 15570426 | |
| MESH:D001249 | Asthma | Ozone | 2.74 | 16373670 17854713 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 3.63 | 19483382 | |
| MESH:D016535 | Bronchial Hyperreactivity | Ozone | 4.04 | 18315731 18417511 14754758 15516495 16777450 19059883 17626835 | |
| MESH:D002100 | Cachexia | Ozone | 5.48 | 16183385 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 4.43 | 15721981 16124888 16050911 3786805 15673190 18705752 15700767 10355542 16227642 16011737 16192424 16097048 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 1.86 | 18788625 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 3.15 | 19176532 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.59 | 18249437 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 2.13 | 3732212 19336974 6623471 7440962 15027814 17522070 15998439 11566570 3786805 10915739 6884620 16177239 7120509 15968718 21278145 9327722 2869522 4309450 10092053 19085960 7179309 16227642 | |
| MESH:D004487 | Edema | pirinixic acid | 2.96 | 12083418 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 9.32 | 12795759 15959796 16045604 12631006 61145 16239168 19224547 17595544 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 9.32 | 20131406 19236843 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 4.10 | 18705752 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.78 | 20558911 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 4.18 | 19110552 19900420 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 3.64 | 18467677 16221962 19772884 19176532 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 5.27 | 16899240 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.63 | 20558911 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 4.74 | 15338365 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.90 | 16306350 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 3.02 | 16239168 16943688 11903743 21278145 17157831 17334410 16221502 17174718 11408273 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 2.42 | 15925388 16248980 18251166 14724832 17708605 14716833 14748882 12667390 18277467 15893842 17823541 17900296 18376398 15650968 18054572 12586293 17869086 18279442 17922224 12609069 12389079 16097048 16638106 18205269 16136751 12958196 18472332 17721639 15052691 15996030 18006644 12898905 18263696 15730626 17714472 20821823 17565644 18418968 16015684 11481614 12666154 12632514 14716496 15876570 16116963 12741479 16011737 18395095 18317297 18429990 17481882 16033810 12445418 18166357 15931870 18420326 14512876 18339082 18472094 18481824 17976157 18187930 14620537 18156304 15818738 17640975 15370692 15362042 17761835 16027843 17698563 18395914 12649538 17766677 15959796 17525996 18412020 15057751 18705752 12445421 15123356 17557913 17944888 12546737 17805973 15673190 18210741 10355542 15338365 13678700 12632512 16192424 17631135 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 2.42 | 15474484 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 2.16 | 17285989 16246199 16964402 15830285 15720792 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 4.82 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 4.14 | 14706259 16899240 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 4.88 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 4.88 | 15890375 20007298 16377806 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 2.86 | 15583823 12014681 | |
| MESH:D008171 | Lung Diseases | Ozone | 3.65 | 8266340 19066396 | |
| MESH:D055370 | Lung Injury | Ozone | 4.50 | 20417186 | |
| MESH:D008175 | Lung Neoplasms | Ozone | 2.10 | 8597069 7614698 | |
| MESH:D008679 | Metaplasia | Ozone | 5.97 | 10496685 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 4.16 | 16239165 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.29 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 3.29 | 16411023 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 2.12 | 17405874 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.89 | 20558911 | |
| MESH:D010538 | Peritonitis | Ozone | 4.78 | 16369182 | |
| MESH:D011014 | Pneumonia | Ozone | 5.14 | 18007984 18381685 18929643 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.56 | 19058328 |
| No data |