AutismKB 2.0

Annotation Detail for PTPRB


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Basic Information Top
Gene Symbol:PTPRB ( DKFZp686E2262,DKFZp686H15164,FLJ44133,HPTP-BETA,HPTPB,MGC142023,MGC59935,PTPB,R-PTP-BETA,VEPTP )
Gene Full Name: protein tyrosine phosphatase, receptor type, B
Band: 12q15
Quick LinksEntrez ID:5787; OMIM: 176882; Uniprot ID:PTPRB_HUMAN; ENSEMBL ID: ENSG00000127329; HGNC ID: 9665
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04520Adherens junction
No data
No data
Pathway IDPathway Name
P00005Angiogenesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PTPRB mRNAincreases expression 19933214
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in decreased expression of PTPRB mRNAdecreases expression 10854235
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PTPRB mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of PTPRB mRNAdecreases expression 19482888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTPRB mRNAincreases expression 19933214
19465110
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of PTPRB mRNAincreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.156195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.1515322242 14514962 11752688
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 6.1415814487
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.9516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2419898480
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9417173139 6705139 1701930 20007298 20935162
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.5211212258
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 4.518340253
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.2911212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 18850075 16120746
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.228697196 15340226 15668235 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Phenobarbital 10.1016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.1016120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.668697196 18606429 16959395 16354765 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.7912878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.7918590791
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 4.4415834431 18617210
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 4.969667754 18055543
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms Phenobarbital 4.7919812893 19073162 19482888 15975961 8742319 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7916984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.4817172636 18308698 1399818 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6919555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.6912111688 16288123 11091918 3440675
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.6215006635
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311399792 11118676 11222880 11896295
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 5.1118410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012640 Seizures Phenobarbital 2.9216876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.3816192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.3818590791
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 3.4512846360
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
KEGG:04520 Adherens junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34010
    • No data
    No data
    Releated drug ID Related drug Name
    PA448948chloroquine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB06989 - {4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID
    DB07068 - (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID
    DB07127 - {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID
    DB08678 - (4-ETHYLPHENYL)SULFAMIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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