AutismKB 2.0

Annotation Detail for PTPRC


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Basic Information Top
Gene Symbol:PTPRC ( B220,CD45,CD45R,GP180,LCA,LY5,T200 )
Gene Full Name: protein tyrosine phosphatase, receptor type, C
Band: 1q31.3-q32.1
Quick LinksEntrez ID:5788; OMIM: 151460; Uniprot ID:PTPRC_HUMAN; ENSEMBL ID: ENSG00000081237; HGNC ID: 9666
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05340Primary immunodeficiency
hsa04514Cell adhesion molecules (CAMs)
hsa04660T cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Axon guidance
Signaling in Immune system
Pathway IDPathway Name
200005BCR signaling pathway
200083CXCR4-mediated signaling events
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00053T cell activation
P00010B cell activation
P00038JAK/STAT signaling pathway
Pathway IDPathway Name
500479Phosphorylation of CD3 and TCR zeta chains
500072Sema4D in semaphorin signaling
Related Diseases/Disorders Top
Desease IDDesease Name
H00091T-B+ Severe combined immunodeficiencies
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1707Multiple myeloma
1807Autoimmune disease
1809HIV infection
1818Systemic scleroderma
1832Congenital abnormality
2053Colon cancer
2111Systemic infection
2245Fetal disease
Desease Name
abnormal splicing
paraparesis
systemic sclerosis
multiple sclerosis
sclerosis, systemic
IMMUNE
lupus erythematosus
HTLV-1 associated myelopathy/tropical spastic
INFECTION
No data
Desease Name
Hepatitic C virus, susceptibility to
Severe combined immunodeficiency, T cell-negative, B-cell/natural killer-cell positive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PTPRC mRNAaffects expression 17562736
C054284 alpha-fluoromethylhistamine [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of PTPRC proteindecreases chemical synthesis|decreases expression 11306145
C061133 Am 80 Am 80 results in decreased expression of PTPRC mRNAdecreases expression 17229644
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPRC mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of PTPRC mRNAdecreases expression 18191166
D001374 Azacitidine Azacitidine results in increased expression of PTPRC mRNAincreases expression 19194470
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PTPRC mRNAdecreases expression 20064835
C095105 bexarotene bexarotene results in increased expression of PTPRC mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A results in increased expression of PTPRC mRNAincreases expression 18180321
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PTPRC proteinincreases expression 12629582
C423222 cotylenin A cotylenin A results in increased expression of PTPRC mRNAincreases expression 16129123
D004041 Dietary Fats Dietary Fats results in decreased expression of PTPRC mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PTPRC mRNAincreases expression 15834898
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of PTPRC geneincreases mutagenesis 16724327
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of PTPRC mRNAincreases expression 17187413
D006632 Histamine [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of PTPRC proteindecreases chemical synthesis|decreases expression 11306145
D006632 Histamine [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC proteinaffects binding|decreases expression|decreases reaction|increases activity 11306145
D006632 Histamine [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC proteinaffects binding|decreases expression|decreases reaction|increases activity 11306145
D009151 Mustard Gas Mustard Gas affects the expression of PTPRC mRNAaffects expression 15651846
C056709 N,N-diacetylcystine N,N-diacetylcystine affects the expression of PTPRC proteinaffects expression 17157857
C043062 N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine results in decreased expression of PTPRC proteindecreases expression 11306145
D010126 Ozone Ozone results in decreased expression of PTPRC mRNAdecreases expression 12763052
17095637
C041786 palm oil palm oil results in decreased expression of PTPRC mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of PTPRC mRNAdecreases expression 18445702
17426115
C023990 tiotidine [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC proteinaffects binding|decreases expression|decreases reaction|increases activity 11306145
D014212 Tretinoin Tretinoin results in increased expression of PTPRC mRNAincreases expression 16129123
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of PTPRC mRNAincreases expression 17982090
D014311 Triprolidine [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC proteinaffects binding|decreases expression|decreases reaction|increases activity 11306145
C025643 vinclozolin vinclozolin affects the expression of PTPRC mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9814692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 10.6210737359
MESH:D000236 Adenoma Benzo(a)pyrene 10.626695378
MESH:D000236 Adenoma Ethylnitrosourea 10.626695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.786705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.2516434500
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000544 Alzheimer Disease Ozone 2.3915513908
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7416412693
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 20453842
MESH:D001172 Arthritis, Rheumatoid Am 80 7.2716819260
MESH:D001172 Arthritis, Rheumatoid Ozone 7.2715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.2716292516
MESH:D001249 Asthma Histamine 10.7816387687
MESH:D001249 Asthma Mustard Gas 10.7810378619
MESH:D001249 Asthma Ozone 10.7817854713 16373670
MESH:D001249 Asthma Tretinoin 10.7816456186
MESH:D050197 Atherosclerosis Am 80 4.2116484594
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001768 Blister Mustard Gas 4.9319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2916206674 16197459
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6814991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0916357521 16651633 16436596 18412241 15144691
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8617474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 2.8616818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 2.8617123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.8620435547
MESH:D001943 Breast Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 2.8618986763
MESH:D001943 Breast Neoplasms Tretinoin 2.8616873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5019059883 15516495 17626835 18315731 18417511 16777450 14754758
MESH:D001986 Bronchial Spasm Histamine 5.5918298128
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7510378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002100 Cachexia Ozone 4.5116183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5610355542 15721981 3786805 16192424 16097048 15673190 16124888 16227642 18705752 15700767 16011737 16050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 6.2810737359 6705139 3084413 17761372 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.283084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.2818788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.281917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1516247446
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.4020419170
MESH:D002294 Carcinoma, Squamous Cell N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 7.4018986763
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.4016051514 16096774
MESH:D002386 Cataract Acetaminophen 6.7810977129
MESH:D002386 Cataract Tretinoin 6.7817460283
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.5716003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7517160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1915861022 17681005 11677210 16919318 17333356 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 7.1919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Tretinoin 2.579407595
MESH:D003092 Colitis Tretinoin 9.0317035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.0316867261 16804969 16782535 11698051 18023891 17936198 16474422 18200517 17991707
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3717276891
MESH:D003110 Colonic Neoplasms arsenite 2.5515037631
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.819211117 17551590 9142499 10589399 9224671 16925845 9125849 14991402 8800419 9664655
MESH:D003456 Cryptorchidism vinclozolin 4.1214966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5212594235 17906064 19420014 10915739 10774834 18713872 19923254 12705907 19370779 15968718 17562736 14725611 11529661 16081117 16485898 11461765 12392966 16109766 11834606 19416960 12958197 19739265 16393943 18071297 2444490 16177239 16227642 19085960 11743745 16781746 14986274 11287661 12540782 12153990 14550746 15619225 17522070 11421492 11739529 19164858 10663392
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.5216227642 7179309 9327722 3732212 6623471 3786805 4309450 21278145 11566570 6884620 7440962 10092053 19085960 19336974 17522070 7120509 16177239 15027814 15998439 10915739 2869522 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7518357618
MESH:D004487 Edema Mustard Gas 6.2111428647 9260866 11402378 11428631
MESH:D004487 Edema pirinixic acid 6.2112083418
MESH:D004489 Edema, Cardiac Tretinoin 4.2418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 8.7916819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.7912538720
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9616569247
MESH:D004802 Eosinophilia Histamine 4.8312689652
MESH:D004890 Erythema Mustard Gas 4.939357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9516530937
MESH:D005124 Eye Abnormalities Tretinoin 3.4116938888 9664655
MESH:D005234 Fatty Liver arsenite 22.4718296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.4715959796 19224547 12631006 12795759 16045604 17595544 16239168 61145
MESH:D005234 Fatty Liver Dietary Fats 22.4719004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.4715345470
MESH:D005234 Fatty Liver pirinixic acid 22.4719236843 20131406
MESH:D005355 Fibrosis arsenite 25.3718296743
MESH:D005355 Fibrosis Carbon Tetrachloride 25.3718705752
MESH:D005355 Fibrosis Dietary Fats 25.3718296743
MESH:D005355 Fibrosis Tretinoin 25.3717994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 25.3717994277
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0716417039
MESH:D005909 Glioblastoma Ethylnitrosourea 6.9316436596
MESH:D005909 Glioblastoma Tretinoin 6.9317312396
MESH:D005910 Glioma Ethylnitrosourea 3.4018412241 16357521 16651633
MESH:D006258 Head and Neck Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 8.0518986763
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2620471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.269664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.086705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.206705139
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3819110552 19900420
MESH:D006526 Hepatitis C marker/mechanism
MESH:D006529 Hepatomegaly pirinixic acid 2.7716221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 7.0316870215
MESH:D006930 Hyperalgesia Tretinoin 7.0316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3921332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1617937319
MESH:D007248 Infertility, Male vinclozolin 6.1616467254
MESH:D007249 Inflammation Dietary Fats 4.8720412841
MESH:D007249 Inflammation Mustard Gas 4.8711428631 17524151 11428647 9357497 11402378 9260866 8975870 11428620 16001271
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4918200517
MESH:D007333 Insulin Resistance bisphenol A 11.4816393666
MESH:D007333 Insulin Resistance Dietary Fats 11.4818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 11.4816306350
MESH:D007410 Intestinal Diseases Tretinoin 9.2417994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 9.2417994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.6915992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.0712587719 15629191
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.7517379185
MESH:D007938 Leukemia Azacitidine 6.2819148494
MESH:D007938 Leukemia Tretinoin 6.2817143497
MESH:D007951 Leukemia, Myeloid Azacitidine 9.1119077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.1116482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.0518720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0517596541 16294345 19850784
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.9819299654
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 7.6716819260 16531727
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.679834237 16823087 16766008 19642359 15748426 17649720 16331271 16788101 17712046 17339181 19029980 17294898 17506722 16891316 12679006 19075265 16140955 17361223 17217047 16935935 17368321 17107899 19225113 17301526 19035177
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5016417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.159224671
MESH:D008103 Liver Cirrhosis arsenite 10.3718296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3721278145 16239168 11408273 11903743 17334410 16221502 16943688 17174718 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3117708605 20821823 15931870 15057751 15052691 18210741 16033810 17631135 15925388 11481614 18395095 16116963 18006644 18339082 18472094 18418968 18412020 16248980 14620537 15996030 12389079 18205269 15959796 13678700 17761835 12667390 16011737 12741479 17557913 18166357 17698563 14724832 15818738 15650968 14748882 12586293 14716833 17525996 18420326 12958196 12609069 16192424 14512876 10355542 17869086 15338365 18472332 18156304 18263696 12632512 14716496 15893842 16097048 15876570 17976157 18279442 12649538 16027843 17714472 12445421 17900296 18481824 18376398 17721639 18251166 18187930 18277467 18317297 16638106 17640975 18395914 17805973 16136751 15673190 16015684 15730626 12445418 17565644 17922224 18705752 12898905 15362042 15370692 17766677 17481882 12632514 18054572 18429990 17823541 17944888 12666154 15123356 12546737
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.3118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.7016610002 12969438 19460945 16611625 11587558 19014921 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7015830285 16964402 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7514706259 16899240
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 10.0010737359 16273603 11376686 18001218 10672840 14678523
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.0020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.0019294768
MESH:D008113 Liver Neoplasms pirinixic acid 10.0016377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 5.816150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.8112014681 15583823
MESH:D008171 Lung Diseases Mustard Gas 7.1118702808 18161513
MESH:D008171 Lung Diseases Ozone 7.1119066396 8266340
MESH:D055370 Lung Injury Ozone 3.6320417186
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 12.4811376686
MESH:D008175 Lung Neoplasms arsenite 12.4816809336
MESH:D008175 Lung Neoplasms Azacitidine 12.4821224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.4818816296 18520028 18569708 17053015 20135361 6695378 20064080 20869020 20464547
MESH:D008175 Lung Neoplasms bexarotene 12.4817849452
MESH:D008175 Lung Neoplasms Ethylnitrosourea 12.486695378 17703301 16271038 16019985
MESH:D008175 Lung Neoplasms Mustard Gas 12.488781369 3148597
MESH:D008175 Lung Neoplasms Ozone 12.488597069 7614698
MESH:D008223 Lymphoma Ethylnitrosourea 3.7815790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8215375218
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.1315591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.1310838139 10767621 18041768
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Histamine 3.7517709802
MESH:D008545 Melanoma Tretinoin 3.7516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008579 Meningioma Ethylnitrosourea 5.7517943659
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008679 Metaplasia Ozone 4.8710496685
MESH:D009006 Monosomy Azacitidine 5.8519299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009101 Multiple Myeloma Am 80 7.6017229644
MESH:D009101 Multiple Myeloma Azacitidine 7.6018443271 19549372
MESH:D009103 Multiple Sclerosis marker/mechanism
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.2817596541 17611569 18720364 19805378
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7716411023
MESH:D009369 Neoplasms Benzo(a)pyrene 7.5311141357
MESH:D009369 Neoplasms pirinixic acid 7.5317405874
MESH:D009369 Neoplasms Tretinoin 7.5316594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.1816707424
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5519196722
MESH:D009389 Neovascularization, Pathologic arsenite 4.1815738583
MESH:D009421 Nervous System Malformations bisphenol A 9.0611399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 9.069125849
MESH:D009436 Neural Tube Defects Tretinoin 2.919142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.1916003739 16651423 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D009503 Neutropenia Mustard Gas 3.7616761898 7688884
MESH:D009765 Obesity Dietary Fats 4.2418674790 21332399 20518802 18457598 17217161 11836018 20132043 19632207 16723640
MESH:D009765 Obesity pirinixic acid 4.2420558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7517160924
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.2816936753
MESH:D010146 Pain Acetaminophen 5.9816870215
MESH:D010146 Pain Tretinoin 5.9816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.3815976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9917698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010538 Peritonitis Ozone 3.9116369182
MESH:D011014 Pneumonia Ozone 4.1718929643 18007984 18381685
MESH:D011041 Poisoning Mustard Gas 3.5915727166
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.0110548101
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.0118220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0020887781
MESH:D011471 Prostatic Neoplasms Am 80 2.2316289102
MESH:D011471 Prostatic Neoplasms Azacitidine 2.2318324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2317292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.2316740699
MESH:D011472 Prostatitis vinclozolin 4.7018629315
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.7615861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.7618058305
MESH:D011565 Psoriasis Am 80 4.0116819260
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8410334151 17894541 17720292 17266442 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916283617 16116481
MESH:D012220 Rhinitis Histamine 4.7812689652
OMIM:608971 SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-POSITIVE, NK CELL-POSITIVE marker/mechanism
MESH:D012772 Shock, Septic Triprolidine 5.9918063050
MESH:D012852 Sinusitis Triprolidine 6.107327846
MESH:D012871 Skin Diseases Mustard Gas 2.6615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3210029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 5.3216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.2920155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.2917261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9315790496
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.031399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0317053015
MESH:D014581 Urticaria Acetaminophen 8.4210982225
MESH:D014581 Urticaria Histamine 8.4218298128
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4816129372
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:05340 Primary immunodeficiency
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34011
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA164743471adenosine triphosphate
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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