AutismKB 2.0

Annotation Detail for PTPRF


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Basic Information Top
Gene Symbol:PTPRF ( FLJ43335,FLJ45062,FLJ45567,LAR )
Gene Full Name: protein tyrosine phosphatase, receptor type, F
Band: 1p34.2
Quick LinksEntrez ID:5792; OMIM: 179590; Uniprot ID:PTPRF_HUMAN; ENSEMBL ID: ENSG00000142949; HGNC ID: 9670
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04520Adherens junction
hsa04514Cell adhesion molecules (CAMs)
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
Desease Name
METABOLIC
triglycerides
obesity
insulin
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PTPRF mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of PTPRF mRNAincreases expression 19774075
D000638 Amiodarone Amiodarone affects the expression of PTPRF mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPRF mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of PTPRF mRNAincreases expression 18191166
D001553 Benzbromarone Benzbromarone affects the expression of PTPRF mRNAaffects expression 19483382
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNAaffects cotreatment|decreases expression 17905399
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTPRF mRNAaffects expression 17484886
D002994 Clofibrate Clofibrate affects the expression of PTPRF mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of PTPRF mRNAaffects expression 17602206
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRF mRNAaffects cotreatment|affects expression 17602206
D003314 Corn Oil Corn Oil affects the expression of PTPRF mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in decreased expression of PTPRF mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRF mRNAaffects cotreatment|affects expression 17602206
D005001 Ethionine Ethionine affects the expression of PTPRF mRNAaffects expression 19483382
D005419 Flavonoids Flavonoids results in decreased expression of PTPRF mRNAdecreases expression 18035473
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNAaffects cotreatment|decreases expression 17905399
D009853 Omeprazole Omeprazole affects the expression of PTPRF mRNAaffects expression 19483382
D010656 Phenylephrine Phenylephrine results in decreased expression of PTPRF mRNAdecreases expression 18158353
C006253 pirinixic acid pirinixic acid results in decreased expression of PTPRF mRNAdecreases expression 18445702
17426115
C006253 pirinixic acid pirinixic acid affects the expression of PTPRF mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of PTPRF mRNAaffects expression 19483382
C017947 sodium arsenite sodium arsenite results in decreased expression of PTPRF mRNAdecreases expression 12377979
C025462 sulindac sulfide sulindac sulfide results in decreased expression of PTPRF mRNAdecreases expression 16184548
D013853 Thioacetamide Thioacetamide affects the expression of PTPRF mRNAaffects expression 19483382
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNAaffects cotreatment|decreases expression 17905399
D014415 Tunicamycin Tunicamycin results in decreased expression of PTPRF mRNAdecreases expression 17127020
D014635 Valproic Acid Valproic Acid results in increased expression of PTPRF mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of PTPRF mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7419490988
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000236 Adenoma Diethylnitrosamine 2.736695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.3919052882 17162532 16434500 18056438 19061943 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6916712894 17306315
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0418759972
MESH:D000550 Amblyopia Valproic Acid 5.0217688650
MESH:D000741 Anemia, Aplastic Benzene 4.2117661222 14761424 11369114
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.3117497229
MESH:D001008 Anxiety Disorders vinclozolin 8.3119015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.5418218290 18057881 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.5417460149
MESH:D001281 Atrial Fibrillation Amiodarone 3.7518651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 16609825 18558336 18940202 19232924 17507914 15238991 18775368 19460635 17157402 18316065 17688650 20603192 18177632 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 2.9717594078 20046352
MESH:D001778 Blood Coagulation Disorders Amiodarone 47.3119483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 47.3119483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 47.3119483382
MESH:D001778 Blood Coagulation Disorders Ethionine 47.3119483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 47.3119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 47.3119483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 47.3119483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 47.3119483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.278888407
MESH:D001855 Bone Marrow Diseases Benzene 5.0216183116
MESH:D001919 Bradycardia Phenylephrine 4.3315306635
MESH:D001943 Breast Neoplasms Benzene 2.1517162533 11921183
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1517474063
MESH:D001943 Breast Neoplasms Trichloroethylene 2.1515986119
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5715673190 16097048 10355542 18705752 15721981 16192424 15700767 3786805 16227642 16050911 16124888 16011737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.943084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 10.941701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.9418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.9416540662 20084675 18056438 17428255 20101231 18210153 18494052 16878318 17162532 19701751 21159647 19394651 18978308 18506893 10737359 3581430 20524982 18785209 20512989 3084413 20727157 19052882 16681979 19919837 19107877 16569478 19822196 18788625 16779866 19335982 19418558 10672840 18691550 17761372 18971187 20935162 16698587 19519916 16502159 18393292 16328049 17173139 19383236 16288022 20007298 19208518 20514400 20214788 11831363 17055752 16830150 17978847 18665156 16935385 20432363 19539802 16807293 17138121 19171122
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.9417306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 10.9417997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3812391285
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3218572023
MESH:D006332 Cardiomegaly Phenylephrine 3.4217287366 17124262 16170337 11179087 11754973 15728586
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8219225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8718974383
MESH:D002386 Cataract Acetaminophen 2.4610977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.881399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.8812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.8817174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.8820056578 19524636
MESH:D002637 Chest Pain Omeprazole 4.8915447763
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1519052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.1518291259
MESH:D002779 Cholestasis Cyclosporine 7.2519486331
MESH:D002779 Cholestasis pirinixic acid 7.2519176532
MESH:D003110 Colonic Neoplasms arsenite 2.5515037631
MESH:D019465 Craniofacial Abnormalities Benzene 2.8415643154
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.848888407 16575769 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D003872 Dermatitis Benzene 4.5615902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1420387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.7110663392 14986274 16485898 11834606 16393943 16781746 15619225 14725611 15968718 16227642 16177239 17906064 19923254 11461765 2444490 11529661 16081117 14550746 11421492 10915739 12392966 19739265 19085960 11743745 18713872 19416960 16109766 12540782 19420014 18071297 12153990 11287661 19164858 12958197 10774834 12705907 17562736 11739529 19370779 17522070 12594235
MESH:D056486 Drug-Induced Liver Injury Amiodarone 17.7118218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.7121278145 6623471 16227642 10092053 9327722 6884620 10915739 7179309 7120509 15027814 19336974 15998439 3786805 11566570 19085960 2869522 16177239 3732212 15968718 7440962 17522070 4309450
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.7119107877
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 17.7112963478
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 17.717120509
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 17.711733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.1316613094 21218061 17151854 15991576
MESH:D050171 Dyslipidemias Clofibrate 3.9216707586
MESH:D004421 Dystonia Valproic Acid 3.851851702
MESH:D004487 Edema pirinixic acid 2.3012083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.9517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.713922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.416426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.097750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.853659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D005218 Fat Necrosis Thioacetamide 5.5116456712
MESH:D005234 Fatty Liver Amiodarone 40.0714986274
MESH:D005234 Fatty Liver arsenite 40.0718296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.0717595544 19224547 12795759 16239168 15959796 12631006 16045604 61145
MESH:D005234 Fatty Liver Clofibrate 40.0719224547
MESH:D005234 Fatty Liver Cyclosporine 40.0719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 40.0720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 40.0719236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 40.0719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.6716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.938888407 18558336
MESH:D005355 Fibrosis arsenite 13.6618296743
MESH:D005355 Fibrosis Carbon Tetrachloride 13.6618705752
MESH:D005355 Fibrosis Cyclosporine 13.6612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006402 Hematologic Diseases Benzene 4.4616183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3815929193 18665440 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8119900420 19110552
MESH:D006505 Hepatitis Thioacetamide 8.8116456712
MESH:D006529 Hepatomegaly Amiodarone 7.8915265979
MESH:D006529 Hepatomegaly pirinixic acid 7.8919176532 19772884 18467677 16221962
MESH:D006689 Hodgkin Disease sodium arsenite 2.9812676792
MESH:D006849 Hydrocephalus Valproic Acid 4.6617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.5416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.689751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.6011484837
MESH:D006973 Hypertension Benzene 8.3017940673
MESH:D006973 Hypertension Cyclosporine 8.3010903974
MESH:D006973 Hypertension Phenylephrine 8.3012717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D006984 Hypertrophy Phenylephrine 4.3612791704 18502941
MESH:D007037 Hypothyroidism Amiodarone 10.9218020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.928137927 18031379
MESH:D007248 Infertility, Male sodium arsenite 6.3915346721 12646999
MESH:D007248 Infertility, Male vinclozolin 6.3916467254
MESH:D007249 Inflammation Diethylnitrosamine 4.8318785209
MESH:D007249 Inflammation Flavonoids 4.8317296493
MESH:D007333 Insulin Resistance pirinixic acid 2.5016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 9.3115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.318314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 9.3120008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5712371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9319248655
MESH:D007938 Leukemia Benzene 3.2917119257 14694614 15935818 18335105
MESH:D007951 Leukemia, Myeloid Benzene 4.1317506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.9819478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9816294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D008064 Lipidoses Amiodarone 3.3615342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 10.4318296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4317157831 16943688 17174718 11408273 17334410 16221502 21278145 16239168 11903743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4320032147 18407596 18665156 18522880 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4017525996 15925388 17721639 14620537 17900296 17944888 12445421 15370692 17631135 18472332 17766677 17869086 17557913 17565644 15959796 17698563 18279442 16638106 16027843 18412020 17640975 15338365 18420326 17922224 17714472 18317297 18263696 16116963 18251166 20821823 14716833 17805973 15123356 17761835 12958196 16015684 18418968 15931870 12586293 18166357 17976157 18705752 15996030 12666154 18156304 18006644 15818738 18054572 10355542 18395914 16033810 14716496 18429990 15893842 16192424 15673190 12632512 18210741 12667390 16248980 12609069 15730626 15052691 17708605 18376398 17823541 16011737 12632514 12898905 11481614 13678700 12649538 12741479 18472094 18395095 14724832 16097048 12445418 18339082 12389079 15362042 18277467 18187930 15650968 18205269 16136751 12546737 14512876 15876570 14748882 15057751 18481824 17481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.4015288472 11172339 16489207 18416461 17355460 15316131 18606216 16098781 12085344 11481614 16343077 16126171 16097051 15716488 18615449 18295389 18263696 15288473 15158331 17629604 18395095 12531686 12891558 16248980 17127702 17292413 12557150 15078482 16511523 18458672 17050028 15095483 12175628 14739098 10677585 12679928 15465738 15334695 15362042 15075984 18032466 18380797 18031379 15474484 11682029
MESH:D008107 Liver Diseases Acetaminophen 8.9319784758 11587558 19460945 16611625 19014921 16610002 12969438 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9316246199 16964402 15720792 15830285 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9317034775
MESH:D008107 Liver Diseases Thioacetamide 8.9318374380 16337175 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.1917185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.1916899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 15.1915633222 17276928 12479984 15313186
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.3919294768
MESH:D008113 Liver Neoplasms Clofibric Acid 13.3917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.3915885732 19690152 19255062 19833225 20583210 20452335 20501860 20101389 19294768 9163691 2862719 19426721 19427195 21278145 18978307 18648771 19073162 21047994 21071580 10737359 20434301 18754104 19090486 18644402 20118626 19812893 19996281 19638242 21167192 20405173 19850985 20492335 16942905 19499222 19642983 18977376 2422723 15175105 19551842 19256749 12771043 20137499 19254457 12112319
MESH:D008113 Liver Neoplasms pirinixic acid 13.3915890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 13.3916712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Benzene 13.1512562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.1512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.1519126423 17942915 19519916 19539802 17174075 18775883 21159647 16267830 2563599 3124819 19004024 18544905 18282651 18093689 18164116 18079962 18253720 19009564 17854601 18308698 16842330 9362446
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 13.157955063
MESH:D008133 Long QT Syndrome Amiodarone 3.4215350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 7.0512587719
MESH:D008171 Lung Diseases sodium arsenite 7.0519095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 17.8818516814
MESH:D017563 Lung Diseases, Interstitial Benzene 17.8814698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 17.8817228818
MESH:D008175 Lung Neoplasms arsenite 4.7116809336
MESH:D008175 Lung Neoplasms Benzene 4.7112562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7120970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms sodium arsenite 4.7117077188 15276417 16712894 19931552 17306315
MESH:D008223 Lymphoma Benzene 3.5917119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.2312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.1811921183
MESH:D008545 Melanoma sodium arsenite 2.0116487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0418765137 18803445
MESH:D009101 Multiple Myeloma Benzene 3.5217119195
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.848888407
MESH:D009181 Mycoses Amiodarone 4.6912754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.489029167 3581430
MESH:D009369 Neoplasms pirinixic acid 7.7917405874
MESH:D009369 Neoplasms sodium arsenite 7.7911559025
MESH:D009369 Neoplasms Trichloroethylene 7.7911911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4620056578
MESH:D009389 Neovascularization, Pathologic arsenite 4.2015738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009436 Neural Tube Defects Benzene 11.4615643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.4612854658
MESH:D009436 Neural Tube Defects Valproic Acid 11.4616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.739802331
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases Benzene 4.0017479406 15913788 17178637 16737584 15612468 15935809 17119257 15727169 15576619
MESH:D010051 Ovarian Neoplasms Benzene 4.8912562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8915276417 17306315
MESH:D010146 Pain Acetaminophen 2.2316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3516540662
MESH:D011230 Precancerous Conditions Corn Oil 14.4414668109
MESH:D011230 Precancerous Conditions Cyclosporine 14.4412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.442563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.0220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.0218220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3616039940
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.3311422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7711597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0419110320 15737665
MESH:D012640 Seizures Valproic Acid 2.601511512 17978042 3137016 15475178 16876388 11738929 14763951 11044598
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8718724381
MESH:D012852 Sinusitis Phenylephrine 4.497327846
MESH:D012878 Skin Neoplasms sodium arsenite 2.6018572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 9.0112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.0119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3312833885
MESH:D013272 Stomach Diseases Omeprazole 4.4018545984
MESH:D013274 Stomach Neoplasms Benzene 2.5912562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5918456281
MESH:D013276 Stomach Ulcer Amiodarone 6.9518087811
MESH:D013276 Stomach Ulcer Omeprazole 6.9516755016 10750652 15991576 18237397 17977527 11906479
MESH:D013610 Tachycardia Amiodarone 4.0911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9919225199
MESH:D013953 Thymus Neoplasms Benzene 4.7410850423
MESH:D013959 Thyroid Diseases Amiodarone 4.5519731979
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.897505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.8915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.6518020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 3.9811989578 17467628
MESH:D014178 Translocation, Genetic Valproic Acid 5.0217262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.313119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.4311723127 16712894 17306315 16452187
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.448888407
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5811813266
MESH:D014594 Uterine Neoplasms Benzene 9.4012562636
MESH:D014594 Uterine Neoplasms sulindac sulfide 9.4018645019
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2117056641
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04910 Insulin signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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