AutismKB 2.0

Annotation Detail for PTPRK


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Basic Information Top
Gene Symbol:PTPRK ( DKFZp686C2268,DKFZp779N1045,R-PTP-kappa )
Gene Full Name: protein tyrosine phosphatase, receptor type, K
Band: 6q22.33
Quick LinksEntrez ID:5796; OMIM: 602545; Uniprot ID:PTPRK_HUMAN; ENSEMBL ID: ENSG00000152894; HGNC ID: 9674
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200039Calcineurin-regulated NFAT-dependent transcription in lymphocytes
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
Celiac Disease
IMMUNE
Desease Name
Celiac disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PTPRK proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPRK mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PTPRK mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPRK mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTPRK mRNAaffects expression 17484886
C014347 decitabine decitabine affects the methylation of PTPRK geneaffects methylation 17630775
D005419 Flavonoids Flavonoids results in increased expression of PTPRK mRNAincreases expression 18035473
D005472 Fluorouracil PTPRK protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D015735 Mifepristone Mifepristone results in increased expression of PTPRK mRNAincreases expression 17584828
D009151 Mustard Gas Mustard Gas results in increased expression of PTPRK mRNAincreases expression 15674844
D010656 Phenylephrine Phenylephrine results in decreased expression of PTPRK mRNAdecreases expression 18158353
D011374 Progesterone Progesterone affects the expression of PTPRK mRNAaffects expression 17251523
C021751 tanshinone tanshinone results in decreased expression of PTPRK mRNAdecreases expression 15849732
D013654 Taurine Taurine results in decreased expression of PTPRK mRNAdecreases expression 16579726
D019772 Topotecan PTPRK protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in decreased expression of PTPRK mRNAdecreases expression 17045167
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4120127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.4117638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000740 Anemia Fluorouracil 3.7116511603 17963324 15504547
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1117460149
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Mustard Gas 4.9810378619
MESH:D001249 Asthma Tretinoin 4.9816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001768 Blister Mustard Gas 5.1819167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6116197459 16206674
MESH:D001919 Bradycardia Phenylephrine 4.5615306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715845082 15380490 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9720146248 17474063
MESH:D001943 Breast Neoplasms decitabine 2.9719208741 18320071
MESH:D001943 Breast Neoplasms Fluorouracil 2.9716557594 16595493 18608205 18357371 19217205 16110121 15136595
MESH:D001943 Breast Neoplasms Progesterone 2.9715562024 17614352 16175315
MESH:D001943 Breast Neoplasms tanshinone 2.9719885617 15849732
MESH:D001943 Breast Neoplasms Tretinoin 2.9716443354 16166294 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0117687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7915673190 16097048 15700767 16124888 15721981 3786805 16192424 18705752 16227642 10355542 16050911 16011737
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7016051944
MESH:D002277 Carcinoma Fluorouracil 3.5717121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6021507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6018788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.6016332177 17971768 18930000 16799960 17045692 17088986
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.601917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0218695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.8220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.8219215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.8217066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.8216096774 16051514
MESH:D006332 Cardiomegaly Phenylephrine 3.5315728586 11754973 17124262 11179087 17287366 16170337
MESH:D002386 Cataract Tretinoin 3.0917460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7320889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D003110 Colonic Neoplasms decitabine 3.8717616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8717725105 17018589 16510598 17016597 15001691 17287894 17169374 17172411 16340194 18772588
MESH:D015179 Colorectal Neoplasms decitabine 2.6318981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6316331619 17016601 20501625 17695437 16303861 16282729 18509181 18949393 15148649 17594712 18802399 16391804 16524972 18448328 17401013 15289873 17255274 18288408 17454858 18383874 17094418 14970324
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829664655 17551590 9142499 16925845 14991402 10589399 9125849 8800419 9211117 9224671
MESH:D007644 Darier Disease Fluorouracil 4.8116733453
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.0716025228
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.476884620 15998439 15027814 19085960 7179309 9327722 10092053 6623471 10915739 17522070 3732212 15968718 7120509 11566570 21278145 16227642 3786805 16177239 19336974 2869522 7440962 4309450
MESH:D056486 Drug-Induced Liver Injury Taurine 4.479328219
MESH:D004487 Edema Mustard Gas 3.3111428647 11428631 11402378 9260866
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7917692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004715 Endometriosis Mifepristone 9.4416134523
MESH:D004715 Endometriosis Progesterone 9.4416134523
MESH:D004890 Erythema Mustard Gas 5.189357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.2315173087 16481741 16785472 16337965 17638652
MESH:D005124 Eye Abnormalities Tretinoin 3.5816938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.1716045604 15959796 61145 12631006 17595544 12795759 19224547 16239168
MESH:D005355 Fibrosis Carbon Tetrachloride 8.8518705752
MESH:D005355 Fibrosis Tretinoin 8.8517994277
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D005910 Glioma Fluorouracil 6.5516145905
MESH:D005910 Glioma tanshinone 6.5516955220
MESH:D006258 Head and Neck Neoplasms decitabine 12.9919215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.9915162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.9916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6620471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6614991402 9664655
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006930 Hyperalgesia Tretinoin 3.2116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006973 Hypertension Phenylephrine 3.0712717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D006984 Hypertrophy Phenylephrine 4.5618502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.2419662366
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007248 Infertility, Male decitabine 3.2017581917
MESH:D007249 Inflammation Flavonoids 8.4717296493
MESH:D007249 Inflammation Mustard Gas 8.4717524151 11402378 9357497 8975870 9260866 11428631 11428647 11428620 16001271
MESH:D007249 Inflammation Progesterone 8.4715869954
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9017551590 15992940
MESH:D007680 Kidney Neoplasms Fluorouracil 3.3116985049
MESH:D007938 Leukemia decitabine 6.4319235587 18980019
MESH:D007938 Leukemia Tretinoin 6.4317143497
MESH:D007951 Leukemia, Myeloid decitabine 9.5818454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 9.5819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9717679729 19387464 18460780 18206229 18704418 19010910
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9716294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1516788101 16140955 19075265 17368321 17339181 16766008 19035177 19029980 16891316 15748426 17361223 12679006 16935935 17506722 19642359 17217047 17649720 16331271 17107899 19225113 17294898 9834237 16823087 17712046 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8121278145 16239168 17334410 16943688 11408273 11903743 17157831 16221502 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.7218339082 16097048 12958196 18277467 15996030 17708605 15673190 18420326 18429990 12609069 18156304 17976157 17766677 15959796 18166357 14716496 16192424 18472332 15338365 17823541 17640975 12666154 12445421 15370692 17631135 14512876 17805973 12898905 10355542 17922224 11481614 15818738 15893842 17698563 15730626 16116963 18210741 18705752 18187930 15057751 18418968 17900296 20821823 18395914 17525996 12649538 14724832 12389079 17565644 15931870 12632514 17481882 12586293 18472094 15123356 14716833 18481824 16011737 18205269 18395095 12741479 17869086 12667390 18251166 18317297 18412020 15876570 18376398 18279442 12546737 16248980 14748882 12632512 15052691 17944888 17557913 13678700 18054572 15362042 16638106 15650968 17714472 16027843 15925388 17721639 16136751 12445418 16015684 18263696 16033810 14620537 18006644 17761835
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.7215893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7218397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0815720792 16964402 15830285 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6914706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.7415890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.7420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.7419294768
MESH:D008113 Liver Neoplasms Fluorouracil 10.7418383874 17045692 15113037 16603448
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.008603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.0015583823 12014681
MESH:D008171 Lung Diseases Mustard Gas 3.4518161513 18702808
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8920064080 17053015 20869020 18520028 20135361 20464547 18569708 6695378 18816296
MESH:D008175 Lung Neoplasms Fluorouracil 4.8915246190
MESH:D008175 Lung Neoplasms Mustard Gas 4.898781369 3148597
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8115086387
MESH:D008223 Lymphoma decitabine 3.4219470736
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.8717203775 11408345
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma decitabine 3.4216505122 17785578
MESH:D008545 Melanoma Tretinoin 3.4216752155
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.5416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.5416757204 18986760
MESH:D009101 Multiple Myeloma decitabine 3.3518172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.4819157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4817596541
MESH:D009369 Neoplasms Benzo(a)pyrene 11.9011141357
MESH:D009369 Neoplasms decitabine 11.9019470736 19116145 17925555
MESH:D009369 Neoplasms Fluorouracil 11.9018239605 18600527 16928823
MESH:D009369 Neoplasms Tretinoin 11.9016946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.799125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D009447 Neuroblastoma Topotecan 3.8515176712
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4416436463
MESH:D009503 Neutropenia Mustard Gas 3.9816761898 7688884
MESH:D010051 Ovarian Neoplasms decitabine 11.3619331143 19259094
MESH:D010051 Ovarian Neoplasms Mifepristone 11.3616525653
MESH:D010051 Ovarian Neoplasms Progesterone 11.3617393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 11.3616936753
MESH:D010146 Pain Tretinoin 2.9016870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.6919294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.6916929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.6915976015
MESH:D011041 Poisoning Mustard Gas 3.8015727166
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2317292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2318626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011537 Pruritus Mustard Gas 4.1118058305
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9310334151 17720292 17894541 17620002 17266442
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0118722050 16160472 18286688 15538739
MESH:D012208 Rhabdomyosarcoma decitabine 10.9719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.9716283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012852 Sinusitis Phenylephrine 4.727327846
MESH:D012871 Skin Diseases Mustard Gas 2.7112880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6819755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.3016503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.732093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.7319037991
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7319015929 17522103 19084572 17498489 17172411 16424979 15786421 18396642 18567086 16951190
MESH:D013274 Stomach Neoplasms Tretinoin 4.7317261132
MESH:D013964 Thyroid Neoplasms decitabine 7.3017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3016026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.8416280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.8416051514
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.1319087683 17616700
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.4616803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.4616129372
MESH:D014604 Uveal Neoplasms decitabine 12.9317785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.9316752155
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34019
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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