AutismKB 2.0

Annotation Detail for PTPRM


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Basic Information Top
Gene Symbol:PTPRM ( MGC166994,PTPRL1,R-PTP-MU,RPTPM,RPTPU,hR-PTPu )
Gene Full Name: protein tyrosine phosphatase, receptor type, M
Band: 18p11.23
Quick LinksEntrez ID:5797; OMIM: 176888; Uniprot ID:PTPRM_HUMAN; ENSEMBL ID: ENSG00000173482; HGNC ID: 9675
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04520Adherens junction
hsa04514Cell adhesion molecules (CAMs)
No data
Pathway IDPathway Name
200053Nectin adhesion pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PTPRM proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPRM mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PTPRM mRNAdecreases expression 20106945
20064835
C459604 candoxin candoxin results in decreased expression of PTPRM mRNAdecreases expression 16309724
D016572 Cyclosporine Cyclosporine results in decreased expression of PTPRM mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of PTPRM mRNAincreases expression 12782123
D002117 Calcitriol Calcitriol results in increased expression of PTPRM mRNAincreases expression 16002434
D015741 Metribolone Metribolone results in increased expression of PTPRM mRNAincreases expression 16751804
D009151 Mustard Gas Mustard Gas affects the expression of PTPRM mRNAaffects expression 15651846
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTPRM mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6417659584
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8520146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.8511237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2410378619 17687719
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9712907637 12619106 21507988
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8320419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8311237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 16354765 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6615322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.6112438553
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003967 Diarrhea Dexamethasone 3.897237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004485 Eczema Dexamethasone 4.6612438553
MESH:D004487 Edema Dexamethasone 12.5719703484
MESH:D004487 Edema Mustard Gas 12.579260866 11428647 11402378 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.5712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1315138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.127520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 16959395 15340226 16354765
MESH:D006973 Hypertension Cyclosporine 8.9310903974
MESH:D006973 Hypertension Dexamethasone 8.9317042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9318850075 18670907
MESH:D007249 Inflammation Dexamethasone 8.888960868 11099482
MESH:D007249 Inflammation Mustard Gas 8.889357497 11428620 16001271 17524151 8975870 9260866 11428631 11402378 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4318776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.5216718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5212878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.729163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7221137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.158603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1512151625
MESH:D008171 Lung Diseases Mustard Gas 3.5618161513 18702808
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.7814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7818569708 20464547 18816296 20064080 17053015 6695378 20135361 18520028 20869020
MESH:D008175 Lung Neoplasms Dexamethasone 6.7811195469 15824018
MESH:D008175 Lung Neoplasms Mustard Gas 6.783148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7811884234 19555203
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.6215744524 15867202 16118317
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.639809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009503 Neutropenia Mustard Gas 4.157688884 16761898
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6321297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2417292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2415754350 12479363 18247401 16644109 16289102
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817720292 10334151 17620002 17266442 17894541
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2018379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012871 Skin Diseases Mustard Gas 2.7516961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013272 Stomach Diseases Dexamethasone 4.5615472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Dexamethasone 3.6515138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014605 Uveitis Cyclosporine 12.671336536
MESH:D014605 Uveitis Dexamethasone 12.671336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34020
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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