AutismKB 2.0

Annotation Detail for PTPRN2


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Basic Information Top
Gene Symbol:PTPRN2 ( IA-2beta,IAR,ICAAR,PTPRP )
Gene Full Name: protein tyrosine phosphatase, receptor type, N polypeptide 2
Band: 7q36.3
Quick LinksEntrez ID:5799; OMIM: 601698; Uniprot ID:PTPR2_HUMAN; ENSEMBL ID: ENSG00000155093; HGNC ID: 9677
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04940Type I diabetes mellitus
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PTPRN2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPRN2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PTPRN2 mRNAdecreases expression 20106945
D004610 Ellagic Acid Ellagic Acid results in increased expression of PTPRN2 mRNAincreases expression 12002526
D007657 Ketone Bodies Ketone Bodies results in decreased expression of PTPRN2 mRNAdecreases expression 16807920
C059514 resveratrol resveratrol results in increased expression of PTPRN2 mRNAincreases expression 12569576
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PTPRN2 mRNAaffects cotreatment|affects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PTPRN2 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000169 Acrodermatitis Zinc 5.7417190629 16889938 17202136
MESH:D058186 Acute Kidney Injury resveratrol 4.0916538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.236695378
MESH:D000236 Adenoma resveratrol 7.2315688382
MESH:D000544 Alzheimer Disease resveratrol 4.6616183991 16162502
MESH:D000544 Alzheimer Disease Zinc 4.6616410023 17119284 16325427 16580781
MESH:D000755 Anemia, Sickle Cell Zinc 5.1816916123
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001169 Arthritis, Experimental resveratrol 3.6417115116
MESH:D001249 Asthma Zinc 3.0117085522
MESH:D050197 Atherosclerosis resveratrol 3.4016873680 17967414
MESH:D001930 Brain Injuries Zinc 5.0017109824
MESH:D002545 Brain Ischemia resveratrol 4.6217600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2417474063 20146248
MESH:D001943 Breast Neoplasms resveratrol 2.2417534123 17651959 16393696
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.3312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.3319321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9316675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 11.3720419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 11.3716227395
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 11.3718922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 11.3716543248
MESH:D002318 Cardiovascular Diseases resveratrol 8.1815458977
MESH:D002318 Cardiovascular Diseases Zinc 8.1816936243
MESH:D003092 Colitis resveratrol 4.4316474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.8916507316
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D003920 Diabetes Mellitus Zinc 4.4216479319
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9716873680
MESH:D003928 Diabetic Nephropathies resveratrol 4.1816286809
MESH:D004487 Edema resveratrol 8.138985016
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.1315177302 8273558 11698051 9599246 16716910 8113982 7812673
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3117872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1617923197
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.8116530937
MESH:D004938 Esophageal Neoplasms Zinc 4.8116543248
MESH:D005756 Gastritis Zinc 5.1717241300
MESH:D006130 Growth Disorders Zinc 4.1017217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure Zinc 3.7417162251
MESH:D006335 Heart Injuries Zinc 6.1517074742
MESH:D016481 Helicobacter Infections Zinc 4.7917241300
MESH:D006527 Hepatolenticular Degeneration Zinc 5.0017276780
MESH:D006561 Herpes Simplex resveratrol 4.5216876885
MESH:D006937 Hypercholesterolemia resveratrol 4.2517188708
MESH:D006949 Hyperlipidemias resveratrol 4.2916873680
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9517600658
MESH:D007249 Inflammation resveratrol 5.9016366677
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.907812673 15177302 7562506 8273558 11698051
MESH:D007251 Influenza, Human resveratrol 4.9216624496
MESH:D007511 Ischemia Zinc 4.9416584753
MESH:D007674 Kidney Diseases Zinc 3.4416960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.6616518626
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7216087638
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.982125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9820195826 21137059
MESH:D008113 Liver Neoplasms resveratrol 7.9819073162 20405173 19812893 19321006
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.888603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6520064080 18520028 20135361 20464547 20869020 17053015 6695378 18816296 18569708
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.6511807781
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 11.0711606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 11.078985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 11.0712773700
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008659 Metabolic Diseases resveratrol 4.6217112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009101 Multiple Myeloma resveratrol 3.6317049120 16267019 17164350 14749477 17935668 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2117962980
MESH:D009203 Myocardial Infarction resveratrol 3.1116317513 17188708 17015251 16525036 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 4.2017125593 17015251
MESH:D009205 Myocarditis resveratrol 5.1017322642
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009374 Neoplasms, Experimental resveratrol 4.318985016
MESH:D019636 Neurodegenerative Diseases resveratrol 4.0117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6617929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5217513867
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.2015976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.6012065085 18404319 18922899 8330346
MESH:D011225 Pre-Eclampsia Zinc 4.3617114810
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.5216679765
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6317292933
MESH:D011471 Prostatic Neoplasms resveratrol 2.6317718901 17804756 16731767 15767336 17636462 17675339
MESH:D011471 Prostatic Neoplasms Zinc 2.6312429649 16606632 16517595 16700911
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3716317513 16314181 17520802 17058453 15827377
MESH:D012162 Retinal Degeneration Zinc 4.3016584753
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.2019755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 10.2015837718 8985016
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 10.2012065085 18404319 8985016 11807781 8330346
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7116321402
MESH:D014062 Tongue Neoplasms resveratrol 10.9116227395
MESH:D014062 Tongue Neoplasms Zinc 10.9116543248
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3317473185
MESH:D014594 Uterine Neoplasms resveratrol 4.4217044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6117488730
Pathway ID Pathway Name
KEGG:04940 Type I diabetes mellitus
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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