AutismKB 2.0

Annotation Detail for ACTA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACTA1 ( ACTA,ASMA,CFTD,CFTD1,CFTDM,MPFD,NEM1,NEM2,NEM3 )
Gene Full Name: actin, alpha 1, skeletal muscle
Band: 1q42.13
Quick LinksEntrez ID:58; OMIM: 102610; Uniprot ID:ACTS_HUMAN; ENSEMBL ID: ENSG00000143632; HGNC ID: 129
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200007RhoA signaling pathway
200148Caspase cascade in apoptosis
200118AP-1 transcription factor network
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1728Gastrointestinal tumor
1849Myopathies, Nemaline
No data
No data
Desease Name
Myopathy, actin, congenital, with cores
Myopathy, nemaline, 3
Myopathy, actin, congenital, with excess of thin myofilaments
Myopathy, congenital, with fiber-type disproportion 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C403065 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide binds to ACTA1 proteinaffects binding 19539807
D000082 Acetaminophen Acetaminophen affects the expression of ACTA1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACTA1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of ACTA1 mRNAdecreases expression 18315880
C015001 arsenite arsenite results in increased expression of ACTA1 mRNAincreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of ACTA1 mRNAaffects expression 20127859
C487049 BXL628 BXL628 results in decreased expression of ACTA1 mRNAdecreases expression 16003237
D002104 Cadmium Cadmium results in decreased expression of ACTA1 mRNAdecreases expression 17327700
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of ACTA1 mRNAdecreases expression 17327700
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ACTA1 mRNAincreases expression 15963578
D003345 Corticosterone Corticosterone results in increased expression of ACTA1 mRNAincreases expression 15755911
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of ACTA1 mRNAdecreases expression 16636312
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in decreased expression of ACTA1 mRNA]affects reaction|decreases expression 17888722
D004317 Doxorubicin Doxorubicin results in decreased expression of ACTA1 mRNAdecreases expression 17888722
D004642 Emodin Emodin results in decreased expression of ACTA1 mRNAdecreases expression 16045814
D005480 Flurbiprofen Flurbiprofen results in decreased expression of ACTA1 mRNAdecreases expression 16949054
C470372 halichondramide halichondramide binds to ACTA1 proteinaffects binding 14612571
C072551 HS 142-1 HS 142-1 results in increased expression of ACTA1 mRNAincreases expression 10642269
D007545 Isoproterenol EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]affects cotreatment|affects reaction|increases expression 10710348
D007545 Isoproterenol [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNAaffects cotreatment|increases expression 10710348
C489776 kabiramide C kabiramide C binds to ACTA1 proteinaffects binding 14612571
C489776 kabiramide C kabiramide C binds to ACTA1 protein modified formaffects binding 14612571
C063302 KN 62 KN 62 inhibits the reaction [LIF protein results in increased expression of ACTA1 protein]decreases reaction|increases expression 11073891
D008713 Methimazole Methimazole results in decreased expression of ACTA1 mRNAdecreases expression 17403546
C481648 N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 16513848
C031721 naphthalene naphthalene metabolite binds to ACTA1 proteinaffects binding 16206326
15892573
D009638 Norepinephrine Norepinephrine results in increased expression of ACTA1 mRNAincreases expression 17592507
D010126 Ozone Ozone results in decreased expression of ACTA1 mRNAdecreases expression 12763052
C494474 perchlorate perchlorate results in decreased expression of ACTA1 mRNAdecreases expression 17403546
D010656 Phenylephrine ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 18502941
D010656 Phenylephrine EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]affects cotreatment|affects reaction|increases expression 10710348
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 proteinaffects cotreatment|increases expression 11499749
D010656 Phenylephrine [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNAaffects cotreatment|increases expression 10710348
D010656 Phenylephrine [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNAincreases activity|increases expression 15201137
D010656 Phenylephrine Phenylephrine results in increased expression of ACTA1 mRNAincreases expression 18502941
D010656 Phenylephrine MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 11513749
D010656 Phenylephrine N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 16513848
D010656 Phenylephrine Phenylephrine results in increased expression of ACTA1 mRNAincreases expression 16556869
15795322
15652358
18701451
11230109
16513848
19540241
12435817
17592507
10642269
16517124
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 17592507
D010656 Phenylephrine RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 16517124
D010656 Phenylephrine S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 15652358
D010656 Phenylephrine S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 15652358
D010656 Phenylephrine TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]increases expression|increases reaction 19540241
C006253 pirinixic acid pirinixic acid results in decreased expression of ACTA1 mRNAdecreases expression 17426115
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ACTA1 mRNA]decreases expression|increases reaction 20059764
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 17592507
C038517 prodan prodan binds to ACTA1 proteinaffects binding 14612571
D011441 Propylthiouracil Propylthiouracil results in decreased expression of ACTA1 mRNAdecreases expression 17403546
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACTA1 mRNAincreases expression 15591033
C085516 ulapualide A ulapualide A binds to ACTA1 proteinaffects binding 14612571
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5315322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1620127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 4.1617418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.476695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8216835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.7810680582
MESH:D018246 Adrenocortical Adenoma Arsenic 4.8817306315
MESH:D000419 Albuminuria Doxorubicin 4.2321441931
MESH:D000544 Alzheimer Disease Ozone 2.3715513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7619183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8317460149
MESH:D020261 Arsenic Poisoning Arsenic 2.7716835338 12569548 16251483 18414634
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4815570426
MESH:D001249 Asthma Ozone 2.5417854713 16373670
MESH:D050197 Atherosclerosis Arsenic 6.3819371607 12928151
MESH:D050197 Atherosclerosis Cadmium 6.3815687053
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Norepinephrine 2.358570775
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.6819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 13.6819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.6812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3714601052
MESH:D001919 Bradycardia Isoproterenol 9.876740701
MESH:D001919 Bradycardia Phenylephrine 9.8715306635
MESH:D001932 Brain Neoplasms Doxorubicin 3.5317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9117129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 1.9115136595 15634643 19526202 18382427 18628466 15692762 16115903 17426702 17369602 15939500 15668708 16264153 18234424 15993339 17983394 16322301 11325840 16935488 16096432 18695136 15994142 15567936 16595493 16826403
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4217626835 18417511 18315731 19059883 15516495 16777450 14754758
MESH:D002100 Cachexia Ozone 4.4116183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4610355542 3786805 16192424 15721981 18705752 15673190 16050911 15700767 16124888 16227642 16011737 16097048
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4115504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.263084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.2616507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.2618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.2616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.2617876044 18059187 16023760 16234567
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.011485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.0018922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.0020419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.006189445
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8018640142
MESH:D006332 Cardiomegaly Isoproterenol 14.9411179087 7544033
MESH:D006332 Cardiomegaly Norepinephrine 14.9411179087
MESH:D006332 Cardiomegaly Phenylephrine 14.9417287366 15728586 11179087 11754973 16170337 17124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 14.9418850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3216651473 17519947 18627295 17329180 17924179 16242529 15505089 16455267 16278810 17131338 16109756 17351982 16731534 17007740 16952015 16364871 17928571 15476868 15792986 17308081 17974986 16269455 16612575 17382496 15811867
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8316243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 3.2319152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.0418022660 16973168
MESH:D002375 Catalepsy Norepinephrine 5.218216760
MESH:D002386 Cataract Acetaminophen 2.3910977129
MESH:D002471 Cell Transformation, Neoplastic Cadmium 3.4717332340
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis pirinixic acid 2.5919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9716354765 15340226 15668235 12621046 8697196
MESH:D003110 Colonic Neoplasms arsenite 2.5315037631
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2512952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.9218071297 12594235 17906064 15619225 19416960 12540782 18713872 11739529 11287661 19923254 10663392 2444490 11461765 11529661 10915739 11743745 12153990 14550746 19739265 19420014 14986274 19164858 19085960 19370779 16081117 16227642 11421492 12705907 10774834 16393943 17562736 16177239 12392966 16781746 15968718 17522070 11834606 16485898 12958197 16109766 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.923732212 10915739 10092053 15968718 6884620 19085960 7120509 2869522 15027814 16177239 19336974 21278145 7179309 9327722 3786805 15998439 4309450 16227642 6623471 7440962 17522070 11566570
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 10.9217416283
MESH:D056486 Drug-Induced Liver Injury Prazosin 10.9218071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.9220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004362 Drug Toxicity Doxorubicin 7.3218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3211462148
MESH:D004487 Edema pirinixic acid 5.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.5912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5718230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.0115700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.0117359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8318037988
MESH:D004827 Epilepsy Norepinephrine 4.13821787
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver arsenite 11.5018296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.5019224547 12631006 61145 15959796 16239168 16045604 17595544 12795759
MESH:D005234 Fatty Liver pirinixic acid 11.5020131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4616611131 15751030 16513791 16534752 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2619069698
MESH:D005355 Fibrosis arsenite 18.6218296743
MESH:D005355 Fibrosis Carbon Tetrachloride 18.6218705752
MESH:D005355 Fibrosis Emodin 18.6219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.6220067830
MESH:D005534 Foot Diseases Arsenic 5.236392382
MESH:D005756 Gastritis Acetaminophen 3.3416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6216452187
MESH:D005909 Glioblastoma Doxorubicin 3.1417150277
MESH:D006042 Goiter perchlorate 5.0018801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3115692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8710048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.2616707910 16244372 18674790 17875725 16330681 17888722 16144979 16244371 18006777 12587719 16879835 14766674 16495754
MESH:D006333 Heart Failure Doxorubicin 10.8017481944
MESH:D006333 Heart Failure Isoproterenol 10.8018097624
MESH:D006333 Heart Failure pirinixic acid 10.8020558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6115692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.2116221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2112621046 16120746 15340226
MESH:D006689 Hodgkin Disease Doxorubicin 3.1417606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7115340226 8697196 18606429 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.3916870215
MESH:D006930 Hyperalgesia Prazosin 7.3912727271
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2116899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1717050553
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1212960047 14722030
MESH:D006973 Hypertension Arsenic 7.9616076760 11953799 9931084
MESH:D006973 Hypertension Phenylephrine 7.9612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7715338365
MESH:D006980 Hyperthyroidism Methimazole 5.3114678291
MESH:D006984 Hypertrophy Isoproterenol 10.0312791704
MESH:D006984 Hypertrophy Phenylephrine 10.0318502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.2316093927
MESH:D007021 Hypospadias Diethylstilbestrol 4.2616002989
MESH:D007022 Hypotension Isoproterenol 8.956740701
MESH:D007022 Hypotension Norepinephrine 8.956740701
MESH:D007037 Hypothyroidism Methimazole 10.8918031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.898137927 18031379
MESH:D007246 Infertility Diethylstilbestrol 4.0515036965
MESH:D007249 Inflammation Flurbiprofen 4.8511099482
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8512878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.4216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007642 Keratosis Arsenic 4.6616930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 12.9712587719 15629191
MESH:D007674 Kidney Diseases Cadmium 12.9716226777 16322080 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 12.9716962696
MESH:D007674 Kidney Diseases Doxorubicin 12.9715699352 16775033 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8616707910
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.2115003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7517184923
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.7317077332
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.3417339181
MESH:D008103 Liver Cirrhosis arsenite 6.2218296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2216221502 16943688 17334410 17157831 17174718 21278145 11903743 16239168 11408273
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.2717481882 15876570 18251166 12667390 17922224 12958196 17805973 18418968 15818738 12445421 16638106 15730626 18376398 17761835 18412020 17525996 15338365 18429990 15931870 12741479 18395914 15123356 16248980 18156304 18054572 17631135 18210741 12586293 12649538 12632514 12546737 16027843 12898905 17640975 18277467 15996030 17714472 15362042 18472094 12632512 17557913 17708605 14748882 15673190 16136751 18187930 18472332 16192424 17869086 18339082 11481614 17766677 14620537 16011737 18279442 15650968 18395095 15959796 18705752 17944888 12666154 18420326 16097048 13678700 17900296 14716496 14724832 18205269 18317297 15057751 15052691 20821823 16033810 18006644 16116963 14512876 16015684 17823541 14716833 15370692 12609069 15893842 18166357 17565644 18263696 17976157 18481824 10355542 17698563 12389079 12445418 15925388 17721639
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.2716439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Emodin 6.2715288473
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2712878042
MESH:D008107 Liver Diseases Acetaminophen 5.9912969438 11587558 19460945 16611625 16610002 12587719 19014921 19784758
MESH:D008107 Liver Diseases Arsenic 5.9911134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.9915830285 16964402 15720792 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.4716899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 16.2916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.2920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.2919294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 16.2915890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 16.2920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.2916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 8.6716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6712151625
MESH:D008171 Lung Diseases Ozone 3.1619066396 8266340
MESH:D055370 Lung Injury naphthalene 8.556834280
MESH:D055370 Lung Injury Ozone 8.5520417186
MESH:D008175 Lung Neoplasms Arsenic 7.9717306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenite 7.9716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.9720064080 20464547 20135361 18520028 20869020 17053015 6695378 18569708 18816296
MESH:D008175 Lung Neoplasms Doxorubicin 7.976189445 17418594
MESH:D008175 Lung Neoplasms Ozone 7.978597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.9719555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8215166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.9815700306
MESH:D008223 Lymphoma Doxorubicin 6.9816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2515621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1816002989
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 5.8212807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.8215458769
MESH:D008545 Melanoma Doxorubicin 2.2416827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2519513568
MESH:D008654 Mesothelioma Doxorubicin 2.9317638057
MESH:D008679 Metaplasia Ozone 4.7710496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2115792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9416381670
MESH:D052016 Mucositis Doxorubicin 4.4617415656
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009203 Myocardial Infarction Doxorubicin 8.8019429709 15857846
MESH:D009203 Myocardial Infarction Isoproterenol 8.8019595682 16697266 16538859 16584858 17052832 19172585 15740881
MESH:D009203 Myocardial Infarction pirinixic acid 8.8019151258
MESH:D017202 Myocardial Ischemia Arsenic 8.1515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.1512213967
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 8.0015642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0016411023
MESH:D017696 Myopathies, Nemaline marker/mechanism
OMIM:255310 MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION marker/mechanism
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 7.2811141357
MESH:D009369 Neoplasms Diethylstilbestrol 7.2815313581
MESH:D009369 Neoplasms pirinixic acid 7.2817405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.0915738583
MESH:D009401 Nephrosis Doxorubicin 4.4516899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7315640375 16889571
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.6111399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6114600291
MESH:D009436 Neural Tube Defects Arsenic 3.2416620997
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6118514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.0817056641
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D012516 Osteosarcoma Doxorubicin 3.8615930896
MESH:D010051 Ovarian Neoplasms Arsenic 2.6417306315
MESH:D010146 Pain Acetaminophen 2.1416870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 12.0015371236 16905509 6392382
MESH:D016491 Peripheral Vascular Diseases Cadmium 12.0015687053
MESH:D010538 Peritonitis Ozone 3.8116369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8317983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3516977796 15687265
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8317638057
MESH:D011014 Pneumonia Ozone 4.0718381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.4817184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4811222880 11118676 11399792 11896295
MESH:D011470 Prostatic Hyperplasia BXL628 6.1916957418 15572423
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Cadmium 1.8917075824
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8917136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8916868541 15897917 16888761 16729912 15749863 18437689
MESH:D011471 Prostatic Neoplasms Flurbiprofen 1.8917409433
MESH:D011507 Proteinuria Arsenic 3.7121343184
MESH:D011654 Pulmonary Edema Isoproterenol 4.9210903255
MESH:D051437 Renal Insufficiency Doxorubicin 3.9017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012509 Sarcoma Doxorubicin 3.7117203757 15625365 15675481 16767912 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4617846226
MESH:D012852 Sinusitis Phenylephrine 4.387327846
MESH:D012871 Skin Diseases Arsenic 2.6616353154 17453740 16759981 17050553 6392382 17938729 18709164 15952646 19834688 17548696 16702368
MESH:D012878 Skin Neoplasms Arsenic 12.2815504454 16251483 17976673 17050553 19538983 17029826
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.2810029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 12.2815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2816192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2515625365 17203757 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 4.3816709447 16002989
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D013610 Tachycardia Norepinephrine 5.133261545
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.7416010429 17909728
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.7415710170
MESH:D001749 Urinary Bladder Neoplasms Arsenic 10.8719429237 19322015 18640142 17976673 15987713 17306315 11144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.8717053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.8716452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.8717653716
MESH:D014581 Urticaria Acetaminophen 2.6810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.7516175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.7616690809 15809267
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1216002989 16513791
MESH:D014652 Vascular Diseases Arsenic 4.4117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.5817334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 9.5818097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.3618097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
REACT:17044 Muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24455
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA449780glutathione
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02621 inhibitor Latrunculin A
    DB02772 - Sucrose Sweetening Agents
    DB03021 - Ulapualide A
    DB03431 - Adenosine-5'-Diphosphate
    DB03616 - Kabiramide C
    DB03850 - Jaspisamide A
    DB03903 - Tmr
    DB04151 - 4-Methyl-Histidine
    DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
    DB04629 - Aplyronine A
    DB04774 - Reidispongiolide A
    DB04775 - Reidispongiolide C
    DB04783 - Sphinxolide B
    DB08080 - LATRUNCULIN B
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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