AutismKB 2.0

Annotation Detail for PTPRR


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Basic Information Top
Gene Symbol:PTPRR ( DKFZp781C1038,EC-PTP,FLJ34328,MGC131968,MGC148170,PCPTP1,PTP-SL,PTPBR7,PTPRQ )
Gene Full Name: protein tyrosine phosphatase, receptor type, R
Band: 12q15
Quick LinksEntrez ID:5801; OMIM: 602853; Uniprot ID:PTPRR_HUMAN; ENSEMBL ID: ENSG00000153233; HGNC ID: 9680
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PTPRR mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTPRR mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PTPRR mRNAincreases expression 15336504
D002713 Chlorine Chlorine results in decreased expression of PTPRR mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of PTPRR mRNAaffects cotreatment|affects expression 18636392
D004041 Dietary Fats Dietary Fats results in increased expression of PTPRR mRNAincreases expression 18042831
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PTPRR mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PTPRR mRNAdecreases expression 17557909
17351261
D005996 Nitroglycerin Nitroglycerin results in increased expression of PTPRR mRNAincreases expression 12102619
C484027 oligofectamine oligofectamine results in increased expression of PTPRR mRNAincreases expression 14668052
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of PTPRR mRNAaffects cotreatment|affects expression 18636392
C041786 palm oil palm oil results in increased expression of PTPRR mRNAincreases expression 18042831
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PTPRR mRNAaffects cotreatment|increases expression 17404688
D020849 Raloxifene Raloxifene affects the expression of PTPRR mRNAaffects expression 14699072
C009250 sevoflurane sevoflurane affects the expression of PTPRR mRNAaffects expression 15967596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury Chlorine 4.3820601635
MESH:D000230 Adenocarcinoma Estradiol 4.2611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D000419 Albuminuria Raloxifene 4.6617451421 17308373
MESH:D000544 Alzheimer Disease Ozone 4.4115513908
MESH:D000544 Alzheimer Disease Raloxifene 4.4115800139
MESH:D001161 Arteriosclerosis Dietary Fats 10.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6516373670 17854713
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 11.2115845082 15665606 15380490
MESH:D001930 Brain Injuries Raloxifene 11.2116580743
MESH:D001943 Breast Neoplasms Dietary Fats 1.9920435547
MESH:D001943 Breast Neoplasms Estradiol 1.9917018787 12948864 19861407 17261762 17289903 16675129 14630087 18497071
MESH:D001943 Breast Neoplasms Progesterone 1.9917614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 1.9915572757 16912660 15775269 17595753 17893378 16837676 17952589 15758505 17049068 17261762 17242785 17440819
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7218315731 17626835 18417511 19059883 15516495 14754758 16777450
MESH:D002100 Cachexia Ozone 4.8216183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.987296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9816924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1217572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4815775269
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.787505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7818566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.999022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9917110522 17681005 15861022 16919318 17333356 16105132 11677210
MESH:D003072 Cognition Disorders Raloxifene 4.6915800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2117474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.878970840 12868966 18759878 8156756 11298694 11906362 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003928 Diabetic Nephropathies Estradiol 9.1719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.1717308373 17451421 15920148
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.977440962 18289764 16192314 11289319 1440618 6482804 9328219 9653073 6679447 18692083 8291058 18648102 9022650
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004417 Dyspnea Chlorine 4.7220016425
MESH:D004487 Edema Raloxifene 3.3915860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.7812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.7817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.7815845917
MESH:D016889 Endometrial Neoplasms Estradiol 3.0119148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 3.8216134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver Dietary Fats 13.4919551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.4915345470
MESH:D005234 Fatty Liver Raloxifene 13.4917473493
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005355 Fibrosis Dietary Fats 3.6018296743
MESH:D005739 Gas Poisoning Chlorine 5.1120016425
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006261 Headache Nitroglycerin 5.2911554966 11284996
MESH:D006331 Heart Diseases Raloxifene 3.5711110106
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Raloxifene 2.8817577099 15787275
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Dietary Fats 5.2820412841
MESH:D007249 Inflammation Progesterone 5.2815869954
MESH:D007333 Insulin Resistance Dietary Fats 7.4818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.4816393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007674 Kidney Diseases Estradiol 2.6115618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.516582329
MESH:D007680 Kidney Neoplasms Estradiol 7.5115610895
MESH:D007859 Learning Disorders sevoflurane 4.8419212262
MESH:D007889 Leiomyoma Raloxifene 4.5516973256
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.56598648 3712494 1399818 6587162
MESH:D008171 Lung Diseases Ozone 3.418266340 19066396
MESH:D055370 Lung Injury Ozone 3.9220417186
MESH:D008175 Lung Neoplasms Ozone 2.097614698 8597069
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.1711408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008569 Memory Disorders sevoflurane 4.8119212262
MESH:D008679 Metaplasia Ozone 5.2010496685
MESH:D008708 Methemoglobinemia Nitroglycerin 4.793537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.1914659530
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4716497877
MESH:D009203 Myocardial Infarction Nitroglycerin 3.8014729435
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009232 Myxoma Raloxifene 5.6516343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Estradiol 3.7211399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009765 Obesity Dietary Fats 2.3020132043 21332399 20518802 19632207 11836018 18674790 16723640 17217161 18457598
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.476482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010024 Osteoporosis Raloxifene 3.4215775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2917823083 15758505 15579764 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 4.9219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9216525653 17393432
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010538 Peritonitis Ozone 4.2016369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D011014 Pneumonia Ozone 4.4818007984 18381685 18929643
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3316740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3315731164 16220300 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D011693 Purpura Raloxifene 5.6515770314
MESH:D012120 Respiration Disorders Chlorine 5.3118579056
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.718532709
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3615862959 16503802
MESH:D020521 Stroke Raloxifene 3.8616837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.927505956 3712494 1399818 6582329 6587162
MESH:D013978 Tibial Fractures Estradiol 14.0419048282
MESH:D013978 Tibial Fractures Raloxifene 14.0419048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.278074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.2717572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.3116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6516343187
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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